Results 101 to 110 of about 998,991 (321)
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
On the extremal semi-Lipschitz functions
Journal of Numerical Analysis and Approximation Theory, 2002 The extremal elements of the unit balls of Banach spaces play an important role in the study of the geometry of the space as well as in various applications.
Costică Mustăţa
doaj +2 more sources
Conversion Factors for U. S. Customary and SI (Metric) Units of Measurements [PDF]
, 1981 Charles W. Averre, M. K. Beute
openalex +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
MathematicsDefining an adequate unit size is often crucial in brain imaging analysis, where datasets are complex, high-dimensional, and computationally demanding. Unit size refers to the spatial resolution at which brain data is aggregated for analysis.
Jihnhee Yu, HyunAh Lee, Zohi Sternberg
doaj +1 more source
Microfluidic electro‐viscoelastic manipulation of extracellular vesicles
FEBS Open Bio, EarlyView.The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh +7 more
wiley +1 more source
On the boundary behavior of the holomorphic sectional curvature of the Bergman metric
Le Matematiche, 2006 We obtain a conceptually new differential geometric proof of P. F. Klembeck’s result (cf. [9]) that the holomorphic sectional curvature k g (z ) of the Bergman metric of a strictly pseudoconvex domain Ω ⊂ ℂ n approaches −4/(n + 1 ...
Elisabetta Barletta
doaj