Results 91 to 100 of about 1,013,760 (323)

POTENSI DAN TINGKAT PEMANFAATAN SUMBERDAYA IKANDEMERSAL DI PERAIRAN KABUPATEN PEKALONGAN

open access: yesAgriekonomika, 2012
Pekalongan Regency seawaters is one of potential demersal fish distribution area. If resources utilization are uncontrol, the resources will be threatened by fishing effort increase. Information about potency and utilization rate should be known.
Novita Lusi Andriani, Dian Ayunita NND
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Bayesian Non-Parametric Inference for Multivariate Peaks-over-Threshold Models

open access: yesEntropy
We consider a constructive definition of the multivariate Pareto that factorizes the random vector into a radial component and an independent angular component. The former follows a univariate Pareto distribution, and the latter is defined on the surface
Peter Trubey, Bruno Sansó
doaj   +1 more source

Graininess of RGB-Display Space

open access: yesi-Perception, 2018
RGB –display space, that is, the ‘ RGB –cube’, was sampled at 3,000 locations, uniformly and randomly distributed. Fifty observers contributed 60 samples each. At each location, participants synthesised a copy of the target, using a generic colour picker.
Jan Koenderink   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Quasi-homogeneous associative functions

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1998
A triangular norm is a special kind of associative function on the closed unit interval [0,1]. Triangular norms (or t-norms) were introduced in the context of probabilistic metric space theory, and they have found applications also in other areas, such ...
Bruce R. Ebanks
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

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