Results 111 to 120 of about 180,999 (303)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
A study of the effectiveness of a teaching unit on length in the metric system
, 1976 The purpose of this study was to determine the effectiveness of a unit in teaching measurement in the metric system to grade seven students. -- To do this the experimenter considered the following questions: -- 1.
Hackett, Neville Raymond
core
On the extremal semi-Lipschitz functions
Journal of Numerical Analysis and Approximation Theory, 2002 The extremal elements of the unit balls of Banach spaces play an important role in the study of the geometry of the space as well as in various applications.
Costică Mustăţa
doaj +2 more sources
Metric completion of $Diff([0,1])$ with the $H1$ right-invariant metric
, 2019 We consider the group of smooth increasing diffeomorphisms Diff on the unit interval endowed with the right-invariant $H^1$ metric. We compute the metric completion of this space which appears to be the space of increasing maps of the unit interval with ...
Tahraoui, Rabah +3 more
core +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
On the intrinsic geometry of a unit vector field [PDF]
, 2002 summary:We study the geometrical properties of a unit vector field on a Riemannian 2-manifold, considering the field as a local imbedding of the manifold into its tangent sphere bundle with the Sasaki metric.
Yampolsky, A.
core
On the boundary behavior of the holomorphic sectional curvature of the Bergman metric
Le Matematiche, 2006 We obtain a conceptually new differential geometric proof of P. F. Klembeck’s result (cf. [9]) that the holomorphic sectional curvature k g (z ) of the Bergman metric of a strictly pseudoconvex domain Ω ⊂ ℂ n approaches −4/(n + 1 ...
Elisabetta Barletta
doaj