Results 101 to 110 of about 180,999 (303)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Lipschitz constants for a hyperbolic type metric under Möbius transformations
summary:Let $D$ be a nonempty open set in a metric space $(X,d)$ with $\partial D\neq \emptyset $. Define $$ h_{D,c}(x,y)=\log \bigg (1+c\frac {d(x,y)}{\sqrt {d_D(x)d_D(y)}}\bigg ), $$ where $d_D(x)=d(x,\partial D)$ is the distance from $x$ to the ...
Wu, Yinping +3 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Object-oriented cohesion as a surrogate of software comprehension: An empirical study
, 2005 The concept of software cohesion in both the procedural and object-oriented paradigm is well known and documented. What is not so well known or documented is the perception of what empirically constitutes a cohesive 'unit' by software engineers.
Tucker, A +3 more
core
Bayesian Non-Parametric Inference for Multivariate Peaks-over-Threshold Models
EntropyWe consider a constructive definition of the multivariate Pareto that factorizes the random vector into a radial component and an independent angular component. The former follows a univariate Pareto distribution, and the latter is defined on the surface
Peter Trubey, Bruno Sansó
doaj +1 more source
Graininess of RGB-Display Space
i-Perception, 2018 RGB –display space, that is, the ‘ RGB –cube’, was sampled at 3,000 locations, uniformly and randomly distributed. Fifty observers contributed 60 samples each. At each location, participants synthesised a copy of the target, using a generic colour picker.
Jan Koenderink +2 more
doaj +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
An imbedding theorem for metric spaces
, 1976 A simple solution to the imbedding problem for the class of separable metric spaces has been known for a long time: (Urysohn’s Imbedding Theorem) A topological space is separable metric if, and only if, it can be imbedded in the topological product of ...
Stephen Leon Lipscomb
core +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source