Results 111 to 120 of about 5,269,237 (355)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
wiley +1 more source
Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima +6 more
wiley +1 more source
POTENSI DAN TINGKAT PEMANFAATAN SUMBERDAYA IKANDEMERSAL DI PERAIRAN KABUPATEN PEKALONGAN
Agriekonomika, 2012 Pekalongan Regency seawaters is one of potential demersal fish distribution area. If resources utilization are uncontrol, the resources will be threatened by fishing effort increase. Information about potency and utilization rate should be known.
Novita Lusi Andriani, Dian Ayunita NND
doaj
Bayesian Non-Parametric Inference for Multivariate Peaks-over-Threshold Models
EntropyWe consider a constructive definition of the multivariate Pareto that factorizes the random vector into a radial component and an independent angular component. The former follows a univariate Pareto distribution, and the latter is defined on the surface
Peter Trubey, Bruno Sansó
doaj +1 more source
Graininess of RGB-Display Space
i-Perception, 2018 RGB –display space, that is, the ‘ RGB –cube’, was sampled at 3,000 locations, uniformly and randomly distributed. Fifty observers contributed 60 samples each. At each location, participants synthesised a copy of the target, using a generic colour picker.
Jan Koenderink +2 more
doaj +1 more source
Appendix B. Tabulation of Some Gas Properties in Metric Units [PDF]
, 2010 Center for Chemical Process Safety
openalex +1 more source