Results 41 to 50 of about 86,298 (291)
Metabolism of metronidazole in humans.
, 2021 In the human liver, metronidazole is metabolized by side-chain hydroxylation, oxidation or glucuronidation to form more polar metabolites. Metronidazole can also undergo modification by gut microbiota producing reduced metabolites such as N-(2 ...
Iveta Zapletalová (11668754) +9 more
core +1 more source
Proteomic analysis of a NAP1 Clostridium difficile clinical isolate resistant to metronidazole. [PDF]
PLoS ONE, 2014 BACKGROUND: Clostridium difficile is an anaerobic, Gram-positive bacterium that has been implicated as the leading cause of antibiotic-associated diarrhea. Metronidazole is currently the first-line treatment for mild to moderate C.
Patrick M Chong +8 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou +9 more
wiley +1 more source
Advanced Science, EarlyView.Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu +10 more
wiley +1 more source
Metronidazole-induced encephalopathy in a patient with infectious colitis: a case report
Journal of Medical Case Reports, 2011 Introduction Encephalopathy is a rare disease caused by adverse effects of antibiotic drugs such as metronidazole. The incidence of metronidazole-induced encephalopathy is unknown, although several previous studies have addressed metronidazole ...
Park Ik +4 more
doaj +1 more source
Acta Dermato-Venereologica, 1976 The strong activity of metroindazole against obligate anaerobes suggested that the organism Proprionobacterium acnes and the disease acne vulgaris might respond to treatment with this drug. Thirty-three clinical isolated of P. acnes were tested and found to be highly resistant to metronidazole. Prospects for its successful use in acne are remote.
R M, Bannatyne, N M, Harnett
openaire +2 more sources
Advanced Science, EarlyView.Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao +9 more
wiley +1 more source
Children, 2022 Metronidazole-induced encephalopathy (MIE) is a rare and unpredictable complication that is most commonly reported in adults. Here, we present the case of MIE in a patient treated with rectal, oral, and intravenous metronidazole.
Karolina Rybak +3 more
doaj +1 more source
A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior
Advanced Science, EarlyView.Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li +12 more
wiley +1 more source
Advanced Science, EarlyView.Genome‐wide CRISPRi and RNA‐seq resolve how B. thetaiotaomicron converts host mucosal glycans into fitness. The study reveals a layered mucin‐utilization architecture in which capsular polysaccharides constrain surface access, extracellular CAZymes and peptidases show functional redundancy, and intracellular catabolic pathways create discrete metabolic
Kangsan Kim +5 more
wiley +1 more source