Results 81 to 90 of about 9,132 (188)

Isoprenoid biosynthesis in the erythrocytic stages of Plasmodium falciparum [PDF]

, 2011
The development of new drugs is one strategy for malaria control. Biochemical pathways localised in the apicoplast of the parasite, such as the synthesis of isoprenic precursors, are excellent targets because they are different or absent in the human ...
JORDÃO, Fabiana Morandi, KATZIN, Alejandro Miguel, KIMURA, Emília Akemi   +2 more
core   +3 more sources

Age‐Dependent Differences in Canakinumab Safety: A Comprehensive Pharmacovigilance Analysis Using the FAERS Database

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT While the efficacy of canakinumab, an anti‐interleukin‐1β monoclonal antibody, is well‐established, its safety profile, particularly across different age groups, remains inadequately explored. Using the FDA Adverse Event Reporting System (FAERS) database, this study evaluated postmarketing safety by analyzing adverse event (AE) reports from ...
Youyang Wang, Ngasin Lam, Xiaoming Huang, Yang Jiao   +3 more
wiley   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, Volume 13, Issue 26, 8 May 2026.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Mevalonate kinase deficiency (hyper IgD syndrome with periodic fever)--different faces with separate treatments: two cases and review of the literature

The Turkish Journal of Pediatrics, 2012
The hyperimmunoglobulinemia D syndrome (HIDS), so-called mevalonate kinase deficiency, is caused by recessive mutations in the gene encoding mevalonate kinase enzyme.
Pınar Gençpınar, Balahan B Makay, Marco Gattorno, Francesco Caroli, Erbil Ünsal   +4 more
doaj  

Histopathologic features in a case of hyperimmunoglobulinemia D syndrome

Indian Dermatology Online Journal, 2015
We describe a case of Mevalonate Kinase Deficiency (MKD) also known as Hyperimmunoglobulinemia D Syndrome (HIDS) presenting as a Sweet-like syndrome in a 5-week-old with multiple erythematous plaques, fever, aseptic meningitis, and bronchiolitis.
Sarah Pace, Jonathan Bingham, Michael Royer   +2 more
doaj   +1 more source

The role of Coenzyme Q10 in statin-associated myopathy [PDF]

, 2009
Statins, or 3-hydroxyl-3-methylglutaryl coenzyme HMG-CoA reductase inhibitors,\ud are cholesterol-lowering drugs which are frequently used in the primary and secondary\ud prevention of coronary artery disease. Current research and recommendations support\
Kalra, Dr Sanjay
core  

Development of the autoinflammatory disease damage index (ADDI) [PDF]

, 2016
OBJECTIVES: Autoinflammatory diseases cause systemic inflammation that can result in damage to multiple organs. A validated instrument is essential to quantify damage in individual patients and to compare disease outcomes in clinical studies.
Al-Mayouf, SM, Amaryan, G, Annink, KV, Anton, J, Barron, KS, Benseler, SM, Brogan, PA, Cantarini, L, Cattalini, M, Cochino, AV, De Benedetti, F, De Jesus, AA, Dedeoglu, F, Della Casa Alberighi, O, Demirkaya, E, Dolezalova, P, Durrant, KL, Fabio, G, Frenkel, J, Gallizzi, R, Gattorno, M, Goldbach-Mansky, R, Hachulla, E, Hentgen, V, Herlin, T, Hofer, M, Hoffman, HM, Insalaco, A, Jansson, AF, Kallinich, T, Koné-Paut, I, Kozlova, A, Kuemmerle-Deschner, JB, Lachmann, HJ, Laxer, RM, Martini, A, Nielsen, S, Nikishina, I, Ombrello, AK, Ozen, S, Papadopoulou-Alataki, E, Quartier, P, Ravelli, A, Rigante, D, Russo, R, Simon, A, Ter Haar, NM, Trachana, M, Uziel, Y   +48 more
core   +2 more sources

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

Genetic profiling of autoinflammatory disorders in patients with periodic fever: a prospective study [PDF]

, 2015
Periodic fever syndromes (PFS) are an emerging group of autoinflammatory disorders. Clinical overlap exists and multiple genetic analyses may be needed to assist diagnosis.
Athanasakis, Emmanouil, Bianco, ANNA MONICA ROSARIA, Bortot, Barbara, Crovella, Sergio, DE MARTINO, Eleonora, De Pieri, Carlo, Ronfani, Luca, Severini, Giovanni M, Taddio, Andrea, Tommasini, Alberto, Vuch, Josef   +10 more
core   +3 more sources

Mevalonate kinase somatic mosaicism and bigenic genotypes may explain heterogeneity in mevalonate kinase deficiency [PDF]

Pediatr Rheumatol Online J, 2015
Results Case 1 A pediatric case with splenomegaly, cervical lymphoadenopathy, failure to thrive and anemia, was found to have two pathogenic MVK variants, p.V250I and p. L315G*51, and the Q705K variant on the NLRP3 gene, considered a functional polymorphism.
Shinar Y, Hashkes P, Cohen R, Kessel A, Tirosh I, Padeh S, Arostegui J, Livneh A.   +7 more
europepmc   +3 more sources