Results 91 to 100 of about 9,132 (188)

Gap Analysis of Metabolic Conversions of Off‐Flavors and Antinutrients in Plant‐Based Substrates

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT To drastically reduce the carbon footprint of the food production chain, a major shift towards alternatives to conventional meat and dairy products is required. The use of plant‐based proteins is a promising route, but it also comes with challenges: Plant‐based proteins often contain antinutritional factors and off‐flavors, which can ...
Robin I. Kuijpers, Isabel O. de Moya Clark, Tomás Cavaco, Vivian Nemanič, Beatrice Tagliabue, Ainhoa Valero‐Abad, Wiebe M. Wennekers, Mengqiu Zhang, Koen Van Zwet, Sanne Abeln, Sofia Moco, Caroline E. Paul, Halima Mouhib, Richard A. Notebaart, Eddy J. Smid, Bas Teusink, Herwig Bachmann   +16 more
wiley   +1 more source

Systemic Consequences of Chronic Ethanol Intake: From Microbiome Shifts to Metabolic Impairment

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Chronic ethanol intake disrupts whole‐body homeostasis by reducing energy intake and body mass, impairing physical function, and reshaping the gut microbiome. Microbiota shifts and depletion of short‐chain fatty acids increase gut permeability and drive hepatic inflammation, dyslipidemia, and glucose intolerance.
Muni Swamy Ganjayi, Thomas A. Krauss, Gage E. Demster, Sehyung Park, Garrett B. Anspach, Sarah R. Anthony, Shaohua Wang, Michael Tranter, Robert N. Helsley, Cory W. Baumann   +9 more
wiley   +1 more source

PFAPA syndrome: a review on treatment and outcome. [PDF]

, 2016
The syndrome of periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA syndrome) is the most common cause of periodic fever in childhood. The current pharmacological treatment includes corticosteroids, which usually are efficacious
Hofer, M., Theodoropoulou, K., Vanoni, F.   +2 more
core   +2 more sources

EnzRetro: Enzymatic Retrosynthetic Planning With Site‐Specific Reaction Edits Based on Sequence Generative Architecture

Exploration, Volume 6, Issue 2, April 2026.
EnzRetro bridges retrosynthesis planning and enzymatic engineering through site‐specific reaction edits. This end‐to‐end framework integrates pathway synthesis and enzyme identification into a unified process, achieving superior accuracy and enabling the efficient reconstruction of diverse biosynthetic pathways.
Yahui Cao, Haoshu Chen, Tao Zhang, Xin Zhao, Bingzhi Li, Xiangrui Zheng   +5 more
wiley   +1 more source

Residual N-acetyl-α-glucosaminidase activity in fibroblasts correlates with disease severity in patients with mucopolysaccharidosis type IIIB [PDF]

, 2016
Background: Mucopolysaccharidosis type IIIB (MPS IIIB) is a rare genetic disorder in which the deficiency of the lysosomal enzyme N-acetyl-α-glucosaminidase (NAGLU) results in the accumulation of heparan sulfate (HS), leading to progressive ...
Brüggenwirth, H.T. (Hennie), Hoefsloot, E.H. (Lies), Meijer, O.L.M., Ploeg, A.T. (Ans) van der, Ruijter, G.J.G. (George), Valstar, M.J. (Marlies), van Vlies, N., Wagemans, T., Welling, L., Wijburg, F.A. (Frits)   +9 more
core   +1 more source

Severe Hypoxia Reduces Adenylyl Cyclase 6 Expression and Function in Bronchial Epithelial Cells

FASEB BioAdvances, Volume 8, Issue 4, April 2026.
Adenylyl cyclase 6 (AC6) plays an important role in the generation of cyclic adenosine monophosphate (cAMP) in the lungs. In cystic fibrosis, excessive mucus production and reduced mucociliary clearance create regions of severe hypoxia that can affect cell functions.
Ryan H. Cunnington, Nisha Singh, Marziyeh Shafizadeh, John W. Hanrahan, Shyamala Dakshinamurti, Prashen Chelikani   +5 more
wiley   +1 more source

T cell metabolism drives immunity [PDF]

, 2015
Lymphocytes must adapt to a wide array of environmental stressors as part of their normal development, during which they undergo a dramatic metabolic remodeling process.
Akashi, Ananieva, Anastasiou, Angelini, Araki, Avni, Bauer, Beier, Bensinger, Berger, Berod, Best, Bird, Blagih, Boudil, Boulland, Brestoff, Byersdorfer, Cantó, Carr, Castilho, Cekic, Cham, Cham, Chang, Chapman, Chaudhri, Cheng, Chou, Chouchani, Ciofani, Ciofani, Cipolletta, Cobbold, Cole, Coombes, Crompton, Cui, Curtis, Dang, David O’Sullivan, DeBerardinis, DeBerardinis, Delgoffe, Delgoffe, Denning, Devadas, Doedens, Dulloo, D’Cruz, Elias, Erika L. Pearce, Ernst, Fan, Feuerer, Fields, Finlay, Fletcher, Fox, Fraser, Frauwirth, Furusawa, Galván-Peña, Gatza, Gerriets, Gitenay, Glick, Glozak, Goldrath, González-García, Gorjão, Gubser, Guo, Hall, Han, Hatzivassiliou, Hayashi, Henao-Mejia, Hubbard, Huynh, Imai, Jacobs, Janas, John, Johnston, Jones, Jones, Juntilla, Kaech, Kaelin, Kaesler, Karmaus, Kelly, Kidani, Kim, Kim, Kim, Koike, Kolev, Kopf, Laplante, Lasoudris, Lee, Lee, Levring, Li, Locasale, Lochner, Lu, Lu, Macintyre, Macintyre, MacIver, MacIver, Maekawa, Magri, Maillard, Maraskovsky, Masri, Mezrich, Michael D. Buck, Michalek, Michalek, Miyamoto, Mucida, Munn, Munn, Muranski, Nakaya, Nicklin, Nie, Nurieva, Oestreich, Okoye, Opitz, O’Neill, O’Sullivan, O’Sullivan, O’Sullivan, Pallard, Palmer, Park, Patsoukis, Pearce, Pearce, Pearce, Pearson, Peschon, Pollizzi, Porstmann, Powell, Pua, Pui, Qualls, Radtke, Ramsay, Rao, Rath, Rathmell, Rathmell, Restifo, Rey, Rodríguez-Borlado, Rolf, Ron-Harel, Saint-Ruf, Santarlasci, Scarlata, Schoors, Sena, Sheiness, Shi, Shrestha, Shrestha, Sido, Sikalidis, Sinclair, Smith, Spencer, Stepensky, Sukumar, Sun, Surh, Swainson, Tamás, Tan, Tannahill, Tao, Tarasenko, Thoreen, Thurnher, Turrens, Uyttenhove, van der Windt, van der Windt, van der Windt, van Heerden, van Loosdregt, Vander Heiden, Veal, von Freeden-Jeffry, Wang, Wang, Wellen, Wieman, Williams, Wofford, Xu, Yang, Yang, Yin, Youssef, Yu, Yu, Yu, Zeng, Zheng, Öst   +217 more
core   +2 more sources

The laboratory approach in the diagnosis of systemic autoinflammatory diseases

Reumatismo, 2011
Systemic autoinflammatory diseases are a group of inherited disorders of the innate immunity characterized by the recurrence of febrile attacks lasting from few hours to few weeks and multi-district inflammation of different severity involving skin ...
B. Frediani, M. Galeazzi, O.M. Lucherini, G.D. Sebastiani, D. Rigante, M.G. Brizi, L. Cantarini   +6 more
doaj   +1 more source

Statins and protein prenylation in cancer cell biology and therapy [PDF]

, 2012
El pdf del artículo es la versión post-print.The use of statins has scaled up to become one of the most prescribed medicines in the world and have been very useful in the manegement of cardiovascular diseases and related mortality.
Fernández-Checa, José C., García-Ruiz, Carmen, Morales, Albert   +2 more
core   +2 more sources

Mevalonate kinase-deficient THP-1 cells show a disease-characteristic pro-inflammatory phenotype

Frontiers in Immunology
ObjectiveBi-allelic pathogenic variants in the MVK gene, which encodes mevalonate kinase (MK), an essential enzyme in isoprenoid biosynthesis, cause the autoinflammatory metabolic disorder mevalonate kinase deficiency (MKD).
Frouwkje A. Politiek, Frouwkje A. Politiek, Marjolein Turkenburg, Rob Ofman, Hans R. Waterham, Hans R. Waterham, Hans R. Waterham   +6 more
doaj   +1 more source