Results 71 to 80 of about 9,132 (188)

Targeting the Mevalonate Pathway Suppresses VHL-Deficient CC-RCC through an HIF-Dependent Mechanism. [PDF]

, 2018
Clear cell renal cell carcinoma (CC-RCC) is a devastating disease with limited therapeutic options available for advanced stages. The objective of this study was to investigate HMG-CoA reductase inhibitors, also known as statins, as potential ...
Alvarez, Alejandro, Fruman, David A, Nelson, Luke J, Nguyen, Quy H, Pavesic, Matthew W, Razorenova, Olga V, Singha, Monika K, Thompson, Jordan M   +7 more
core   +1 more source

Climate change and crop resilience: harnessing metabolomics for predicting stress tolerance

New Phytologist, EarlyView.
Summarised methodology for metabolite biomarker discovery and genomic targets selection for those metabolites to predict high‐throughput phenotypic and agronomic traits of interest for direct uptake in breeding programmes. Summary Global warming is driving climate change to levels not experienced since the advent of agriculture, primarily due to ...
Agyeya Pratap, Arash Fazeli, Ali Bandehagh, Nicolas L. Taylor   +3 more
wiley   +1 more source

Long-Term Follow-Up and Optimization of Interleukin-1 Inhibitors in the Management of Monogenic Autoinflammatory Diseases: Real-Life Data from the JIR Cohort

Frontiers in Pharmacology, 2021
Objectives: The major role of interleukin (IL)-1 in the pathogenesis of hereditary recurrent fever syndromes favored the employment of targeted therapies modulating IL-1 signaling. However the best use of IL1 inhibitors in terms of dosage is difficult to
Véronique Hentgen, Isabelle Koné-Paut, Alexandre Belot, Caroline Galeotti, Gilles Grateau, Aurelia Carbasse, Anne Pagnier, Pascal Pillet, Marc Delord, Michael Hofer, Sophie Georgin-Lavialle   +10 more
doaj   +1 more source

Fever tree revisited: From malaria to autoinflammatory diseases [PDF]

, 2015
Over the centuries the idea of recurrent fevers has mainly been associated with malaria, but many other fevers, such as typhoid and diphtheria were cause for concern.
Bianco, ANNA MONICA ROSARIA, Pastore, Serena, Taddio, Andrea, Tommasini, Alberto, Vuch, Josef   +4 more
core   +1 more source

LUCID: An Integrative Approach for Target Discovery and dsRNA Design in Plant Fungal Pathogens

Plant Biotechnology Journal, EarlyView.
LUCID: A computational pipeline for RNAi‐based biofungicide design. ABSTRACT Phytopathogenic fungi pose an escalating threat to global food security and ecosystem stability, as resistance and environmental concerns diminish the effectiveness of conventional fungicides.
Lucía Jiménez‐Castro, Alba López‐Laguna, Dolores Férnandez‐Ortuño, Alejandro Pérez‐García, Álvaro Polonio   +4 more
wiley   +1 more source

Protein misfolding and dysregulated protein homeostasis in autoinflammatory diseases and beyond. [PDF]

, 2015
Cells have a number of mechanisms to maintain protein homeostasis, including proteasome-mediated degradation of ubiquitinated proteins and autophagy, a regulated process of ‘self-eating’ where the contents of entire organelles can be recycled for other ...
A Halle, A Kaser, A Kitamura, A Simon, AA Lobito, AB Singleton, AC Bulua, AK Agarwal, AM Cuervo, Amma F. Agyemang, AR Simard, AR Winslow, AV Matveyenko, B Levine, B Nedjai, B Neerinckx, B Shi, B Wang, C Dode, C Hetz, C Koumenis, C Pintado, CC Ferrari, CG Brook, CM Ethen, CM Larsen, CS Mendes, CS Shi, D Blum-Degen, D Narendra, DG McGonagle, DH Anderson, DS Friedman, E Hetier, ET Chouchani, F Ciccia, F Martinon, F Martinon, F Pickford, F Urano, FS Giovine Di, FS Giovine di, G Boden, H Gao, H Kroeger, H Park, H Snyder, HD Ryoo, HM Gao, HM Gao, HM Hoffman, HW Virgin, I Aksentijevich, I Aksentijevich, I Allaeys, I Mitroulis, I Todd, I Todd, J Feldmann, J Harris, J Hirosumi, J Moscat, J Wu, J Yu, JA Duncan, JA Ehses, JD Rioux, JE Ramos de Carvalho, JJ Chae, JJ Hoozemans, JJ Hoozemans, JL Webb, JP Mear, JP Sherlock, JR Vingerling, JW Crabb, JY Choe, K Arima, K Cadwell, K Nakahira, KK Chung, KS McNaught, KS McNaught, KT Uysal, L Agostini, L Cantarini, L Qin, L Salvado, L Serrano-Marco, L-p Yang, LJ Dickie, LM Ittner, LV Johnson, M Gattorno, M Komatsu, M Lu, M Martinez-Vicente, M Meyer-Luehmann, M Mogi, M Mogi, M Shimazawa, M-J Kang, MC Chartier-Harlin, MC Pott Godoy, MF Gregor, MF McDermott, MG Spillantini, MG Spillantini, MH Polymeropoulos, Michael F. McDermott, MJ Turner, MJ Turner, ML DeLay, ML Huggins, MS Gorbatyuk, N Hosogai, N Mimura, N Romberg, N Yousaf, NK Sharma, NS Dangoria, P Scott, PL McGeer, PN Hawkins, Q Qiu, Q Yao, R Burgh van der, R Goldbach-Mansky, RC Chang, RC Coll, RD Jager, Richard M. Siegel, S Itagaki, S Savic, S Savic, S Xanthoulea, SL Doyle, SL Masters, SL Masters, SL Rebelo, SM Churchman, Stephanie R. Harrison, SW Canna, T Bachetti, T Bachetti, T Hara, T Ryhänen, T Saitoh, T Strowig, T Yoshizaki, T Yoshizaki, The Eye Diseases Prevalence Research, G, U Ozcan, U Ozcan, U Seifert, VT Samuel, W Pan, X Zhang, Y Liu, Y Shi, Y Zhong, Y-H Youm, ZV Wang   +162 more
core   +1 more source

Cross‐Species Reprogramming of Developmental Plasticity and Metabolic Rewiring via Banana‐Derived WUS2 Developmental Regulator

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant regeneration is governed by intrinsic gene regulation and phytohormonal cues. WUSCHEL (WUS) gene promotes regeneration, but its broader functional role remains unexplored. Here, we demonstrate that the constitutive and inducible expression of banana‐derived WUS2 (GN‐WUS2) enhances regeneration in Nicotiana tabacum (tobacco) and Musa ...
Roni Chaudhary, Surender Singh, Usman Ali, Siddharth Tiwari   +3 more
wiley   +1 more source

Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In‐Silico‐Based Future Therapeutic Potential

eFood, Volume 7, Issue 3, June 2026.
Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam, Ahmet B. Ortaakarsu, Sohaib Khatib, Mohamed A. Farag, Mansour Sobeh   +4 more
wiley   +1 more source

Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation [PDF]

, 2013
published_or_final_versio
Chen, J, Lam, KSL, Liu, J, Shepherd, PR, Wang, Y, Wong, NS, Xu, A   +6 more
core   +2 more sources

Umbelliprenin in Food and Medicinal Plants: Phytochemical Occurrence, Biosynthesis, Analytical Approaches, and Biological Activities

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
This review provides an extensive and critical synthesis of current knowledge on umbelliprenin, integrating phytochemical, analytical, biological, ecological, and food science perspectives, and identifies priorities for future research. ABSTRACT Umbelliprenin (7‐farnesyloxycoumarin) is an oxyprenylated coumarin that has gained increasing attention in ...
Chiara Collevecchio, Lorenzo Marchetti, Francesco Epifano, Salvatore Genovese, Serena Fiorito   +4 more
wiley   +1 more source