Results 1 to 10 of about 6,314 (218)

Urinary excretion of mevalonic acid as an indicator of cholesterol synthesis

Journal of Lipid Research, 1996
Urinary excretion of mevalonic acid was investigated as an indicator of cholesterol synthesis. In normolipemic volunteers, excretion of mevalonic acid averaged 3.51 +/- 0.59 (SD) micrograms/kg x day1; (n = 24) and was not different from patients with ...
B Lindenthal, A Simatupang, M T Dotti, A Federico, D Lütjohann, K von Bergmann   +5 more
doaj   +2 more sources

Isoprenoid biosynthesis regulation in poplars by methylerythritol phosphate and mevalonic acid pathways [PDF]

Frontiers in Plant Science, 2022
It is critical to develop plant isoprenoid production when dealing with human-demanded industries such as flavoring, aroma, pigment, pharmaceuticals, and biomass used for biofuels.
Ali Movahedi, Hui Wei, Boas Pucker, Mostafa Ghaderi-Zefrehei, Fatemeh Rasouli, Fatemeh Rasouli, Ali Kiani-Pouya, Ali Kiani-Pouya, Tingbo Jiang, Qiang Zhuge, Liming Yang, Xiaohong Zhou   +11 more
doaj   +2 more sources

Mevalonic acid exerts procoagulant effect by potentiating factor Xa [PDF]

Natural Products and Bioprospecting
Thrombosis pathogenesis is closely linked to dysregulated lipid metabolism and inflammatory processes. However, the direct regulatory role of mevalonate pathway within the coagulation cascade is still not well understood.
Liyuan Niu, Chuanfeng Liu, Shaoying Wang, Qikai Yin, Shiping Lin, Musan Yan, Wenshuo Li, Yuanjie Yin, Wei Wang, Wenjuan Yu, Xiaopeng Tang, Min Xue, Yuewei Wang   +12 more
doaj   +2 more sources

An ultrasensitive enzymatic method for measuring mevalonic acid in serum [PDF]

Journal of Lipid Research, 2012
We have developed a simple, precise, and ultrasensitive enzymatic method for measuring serum mevalonic acid (MVA) concentration, which is thought to be a good indicator of the in vivo cholesterol biosynthesis rate.
Takeshi Matsuoka, Shigeru Ueda, Hideyuki Matsumoto, Masanobu Kawakami   +3 more
doaj   +2 more sources

Case Report: Early-onset mevalonic aciduria in neonates with inflammatory marker elevated [PDF]

Frontiers in Immunology
PurposeThe aim of this study was to present a case of early-onset mevalonic aciduria (MA) in a neonate and summarize the relevant phenotypic and genotypic spectra of MA.Methods and resultsWe describe a neonate who presented with elevated inflammatory ...
Shanshan Xue, Shanshan Xue, Wujuan Shi, Wujuan Shi, Xiaobo He, Xiaobo He, Lihong Hao, Lihong Hao   +7 more
doaj   +2 more sources

A Distinct Phenotype of Mevalonic Acidemia with Absence of Pathogenic Mutations of Mevalonate Kinase Gene [PDF]

مجلة جامعة النجاح للأبحاث العلوم الطبيعية, 2016
Mevalonic aciduria is an autosomal recessive disorder caused by deficiency of mevalonate kinase and characterized by recurrent febrile crisis, ophthalmic and neurological manifestations.
Imad Dweikat, Nadera Damsa, Enas Naser
doaj   +1 more source

Production of Mevalonic Acid by Fermentation [PDF]

Applied Microbiology, 1968
The purpose of this investigation was to select microorganisms that produce substantial quantities of mevalonic acid and to develop an economic fermentation process. To screen for mevalonic acid-producing microorganisms, it was necessary to improve the method for the quantitative determination of this acid.
G, Tamura, K, Ando, K, Kodama, K, Arima
openaire   +2 more sources

Bacterial Metabolism of Mevalonic Acid [PDF]

Journal of Bacteriology, 1967
Soluble cell-free extracts of actinomycete S4 grown on media containing mevalonate catalyze acetoacetate formation from mevalonate, mevaldate, and β-hydroxy-β-methylglutaryl-coenzyme A (CoA). Conversion of mevalonate to acetoacetate involves formation of free β-hydroxy-β-methylglutaryl-CoA, but not free mevaldate.
M A, Siddiqi, V W, Rodwell
openaire   +2 more sources

Mevalonate metabolism by renal tissue in vitro

Journal of Lipid Research, 1974
Previous studies from this laboratory have demonstrated that the kidneys rather than the liver play the major role in the in vivo metabolism of circulating mevalonic acid.
Philip Raskin, Marvin D. Siperstein
doaj   +1 more source

Biosynthesis of Abscisic Acid by the Non-mevalonate Pathway in Plants, and by the Mevalonate Pathway in Fungi [PDF]

Bioscience, Biotechnology, and Biochemistry, 2000
The biosynthetic pathways to abscisic acid (ABA) were investigated by feeding [1-(13)C]-D-glucose to cuttings from young tulip tree shoots and to two ABA-producing phytopathogenic fungi. 13C-NMR spectra of the ABA samples isolated showed that the carbons at 1, 5, 6, 4', 7' and 9' of ABA from the tulip tree were labeled with 13C, while the carbons at 2,
HIRAI, Nobuhiro, YOSHIDA, Ryuji, TODOROKI, Yasushi, OHIGASHI, Hajime   +3 more
openaire   +2 more sources