Diagnostic value of urinary mevalonic acid excretion in mevalonate kinase deficiency (MKD) [PDF]
Pediatr Rheumatol Online J, 2014 Mevalonate kinase deficiency (MKD) is a rare hereditary autoinflammatory syndrome, characterized by recurrent fever episodes with gastrointestinal complaints, rash and arthralgia. The deficient mevalonate kinase activity leads to elevated mevalonic acid, which is excreted in the urine.
Jeyaratnam J +4 more
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Priming by Hexanoic acid induce activation of mevalonic and linolenic pathways and promotes the emission of plant volatiles. [PDF]
Frontiers in Plant Science, 2016 Hexanoic acid is a short natural monocarboxylic acid present in some fruits and plants. Previous studies reported that soil drench application of this acid induces effective resistance in tomato plants against Botrytis cinerea and Pseudomonas syringae ...
Eugenio eLlorens +3 more
doaj +6 more sources
Diverse genetic error modes constrain large-scale bio-based production [PDF]
Nature Communications, 2018 The declining performance of scale-up bioreactor cultures is commonly attributed to phenotypic and physical heterogeneities. Here, the authors reveal multiple recurring intra-pathway error modes that limit engineered E.
Peter Rugbjerg +4 more
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Isoprenoid biosynthesis regulation in poplars by methylerythritol phosphate and mevalonic acid pathways [PDF]
Frontiers in Plant Science, 2022 It is critical to develop plant isoprenoid production when dealing with human-demanded industries such as flavoring, aroma, pigment, pharmaceuticals, and biomass used for biofuels.
Ali Movahedi +11 more
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Mevalonic acid exerts procoagulant effect by potentiating factor Xa [PDF]
Natural Products and BioprospectingThrombosis pathogenesis is closely linked to dysregulated lipid metabolism and inflammatory processes. However, the direct regulatory role of mevalonate pathway within the coagulation cascade is still not well understood.
Liyuan Niu +12 more
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An ultrasensitive enzymatic method for measuring mevalonic acid in serum [PDF]
Journal of Lipid Research, 2012 We have developed a simple, precise, and ultrasensitive enzymatic method for measuring serum mevalonic acid (MVA) concentration, which is thought to be a good indicator of the in vivo cholesterol biosynthesis rate.
Takeshi Matsuoka +3 more
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Case Report: Early-onset mevalonic aciduria in neonates with inflammatory marker elevated [PDF]
Frontiers in ImmunologyPurposeThe aim of this study was to present a case of early-onset mevalonic aciduria (MA) in a neonate and summarize the relevant phenotypic and genotypic spectra of MA.Methods and resultsWe describe a neonate who presented with elevated inflammatory ...
Shanshan Xue +7 more
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A Distinct Phenotype of Mevalonic Acidemia with Absence of Pathogenic Mutations of Mevalonate Kinase Gene [PDF]
مجلة جامعة النجاح للأبحاث العلوم الطبيعية, 2016 Mevalonic aciduria is an autosomal recessive disorder caused by deficiency of mevalonate kinase and characterized by recurrent febrile crisis, ophthalmic and neurological manifestations.
Imad Dweikat, Nadera Damsa, Enas Naser
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Bacterial Metabolism of Mevalonic Acid [PDF]
Journal of Bacteriology, 1967 Soluble cell-free extracts of actinomycete S4 grown on media containing mevalonate catalyze acetoacetate formation from mevalonate, mevaldate, and β-hydroxy-β-methylglutaryl-coenzyme A (CoA). Conversion of mevalonate to acetoacetate involves formation of free β-hydroxy-β-methylglutaryl-CoA, but not free mevaldate.
M A, Siddiqi, V W, Rodwell
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Production of Mevalonic Acid by Fermentation [PDF]
Applied Microbiology, 1968 The purpose of this investigation was to select microorganisms that produce substantial quantities of mevalonic acid and to develop an economic fermentation process. To screen for mevalonic acid-producing microorganisms, it was necessary to improve the method for the quantitative determination of this acid.
G, Tamura, K, Ando, K, Kodama, K, Arima
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