Results 31 to 40 of about 6,314 (218)
Role of cholesterogenesis and isoprenoid synthesis in DNA replication and cell growth
Journal of Lipid Research, 1984 In summary, there is now ample evidence that cell growth, as well as DNA replication, is closely linked to cholesterogenesis in a manner that has only recently been appreciated.
M D Siperstein
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Geranylgeranoic acid, a bioactive and endogenous fatty acid in mammals: a review
Journal of Lipid Research, 2023 Geranylgeranoic acid (GGA) was first reported in 1983 as one of the mevalonic acid metabolites, but its biological significance was not studied for a long time.
Yoshihiro Shidoji
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Impact of Obesity and MASH on Zonal Hepatocellular Statin Exposure: Pharmacodynamic Insights From a Permeability-Limited Multicompartment Liver Model. [PDF]
CPT Pharmacometrics Syst PharmacolObesity, MASH and Statins: Insights from a PBPK/PD Zonal Liver Model. ABSTRACT Statins are frequently prescribed for hyperlipidemia, a common comorbidity in patients with obesity and/or metabolic dysfunction‐associated steatohepatitis (MASH). However, limited knowledge exists on how MASH may alter statin disposition within hepatocytes where the statin ...
Murphy WA +5 more
europepmc +2 more sources
Short, Enantioselective Synthesis of Mevalonic Acid
A new enantioselective synthesis of mevalonic acid that is short, flexible, scalable to gram amounts, and uses readily available starting materials is reported.
Ryan J. Oconnell +3 more
openaire +2 more sources
Effect of mevalonate analogues upon cholesterol biosynthesis
Journal of Lipid Research, 1961 Three analogues of mevalonic acid have been found to inhibit cholesterol biosynthesis in liver homogenates in the following order of efficacy: 3-methyl-3-hydroxy pentanoic acid > Δ2-3-methyl pentenoic acid > Δ3-3-methyl pentenoic acid.
Herbert Weiss +2 more
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Isolated neurological presentations of mevalonate kinase deficiency
JIMD Reports, 2023 Mevalonate kinase (MK) deficiency is a rare autosomal recessive metabolic disorder caused by pathogenic variants in the MVK gene with a broad phenotypic spectrum including autoinflammation, developmental delay and ataxia. Typically, neurological symptoms
Eva M. M. Hoytema van Konijnenburg +3 more
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Journal of Lipid Research, 1972 Earlier experiments have shown that significantly more endogenously generated NADPH is available for reduction of corticosterone in liver homogenates from C57BL/10 male mice than in those from the DBA/2 strain.
Felicia Gaskin, R.B. Clayton
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Frontiers in Microbiology, 2023 IntroductionAbscisic acid (ABA) is an important sesquiterpene compound that regulates the stress resistance of plants. Botrytis cinerea can synthesize ABA via the mevalonic acid pathway.
Dongbo Chen +8 more
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Mevalonic Acid Kinase in Euglena gracilis [PDF]
Plant Physiology, 1967 The isolation and partial purification of mevalonic acid kinase from Euglena gracilis is described. The product of the reaction MVA-5-P has been characterized by paper chromatography. The apparent Km values for l-mevalonic acid, ATP, and Mg(2+) are 3 x 10(-5)m, 6 x 10(-3)m, and 9 x 10(-3)m, respectively.
C Z, Cooper, C R, Benedict
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Group IVC cytosolic phospholipase A2γ is farnesylated and palmitoylated in mammalian cells
Journal of Lipid Research, 2005 Cytosolic phospholipase A2γ (cPLA2γ) is a member of the group IV family of intracellular phospholipase A2 enzymes, but unlike the well-studied cPLA2α, it is constitutively bound to membrane and is calcium independent.
Dawn E. Tucker +6 more
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