Results 31 to 40 of about 5,897 (180)
Ribonuclease Inhibition of Mevalonic Acid Utilization.
Experimental Biology and Medicine, 1958 SummaryUtilization of mevalonic acid as determined by incorporation of the 2-C14-labeled compound into non-saponifiable material or into cholesterol or by disappearance of microbiological activity attributable to mevalonic acid in rat liver homogenates was found to be abolished by a preliminary digestion with ribonuclease.
L D, WRIGHT, M, CLELAND, B N, DUTTA
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Group IVC cytosolic phospholipase A2γ is farnesylated and palmitoylated in mammalian cells
Journal of Lipid Research, 2005 Cytosolic phospholipase A2γ (cPLA2γ) is a member of the group IV family of intracellular phospholipase A2 enzymes, but unlike the well-studied cPLA2α, it is constitutively bound to membrane and is calcium independent.
Dawn E. Tucker +6 more
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Frontiers in Microbiology, 2023 IntroductionAbscisic acid (ABA) is an important sesquiterpene compound that regulates the stress resistance of plants. Botrytis cinerea can synthesize ABA via the mevalonic acid pathway.
Dongbo Chen +8 more
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Acta Societatis Botanicorum Poloniae, 2015 Tecoma stans Juss. callus tissue grown on Murashige-Mei Lie Lin (M-L) and Murashige-Skoog (RT-k) medium supplemented with Tecoma alkaloid precursors like lysine, mevalonic acid lactone and quinolinic acid, were investigated for their alkaloid content by ...
Barbara Dohnal
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Mevalonic Acid as A Precursor in the Biogenesis of Digitoxigenin
Journal of Pharmacy and Pharmacology, 1960 Abstract (±)-Mevalonic acid-2-14C has been injected into a growing plant of Digitalis lanata L. to test if this acid serves as a precursor in the biosynthesis of cardenolides. After nine days a portion of the leaves was extracted and the constituents submitted to paper chromatography followed by autoradiography.
E, RAMSTAD, J L, BEAL
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Mevalonate kinase deficiencies: from mevalonic aciduria to hyperimmunoglobulinemia D syndrome
Orphanet Journal of Rare Diseases, 2006 Mevalonic aciduria (MVA) and hyperimmunoglobulinemia D syndrome (HIDS) represent the two ends of a clinical spectrum of disease caused by deficiency of mevalonate kinase (MVK), the first committed enzyme of cholesterol biosynthesis.
Hoffmann Georg F, Haas Dorothea
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Advanced Science, EarlyView.USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian +9 more
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Gut microbiota dysbiosis and Long COVID susceptibility in chronic kidney disease
VIEW, EarlyView.This study investigated gut microbiota dysbiosis and its association with Long COVID susceptibility in 224 hemodialysis patients. We found that 35.3% of patients developed Long COVID, characterized by neurological symptoms and elevated inflammatory markers, accompanied by significant gut microbiota alterations including enriched proinflammatory taxa ...
Meiling Jin +5 more
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Journal of Lipid Research, 1980 Highly purified human granulocytes synthesize [14C]farnesol and [14C]squalene but not [14C]sterols from [14C]mevalonic acid. Dimethylsulfoxide was found to be an excellent vehicle for carrying [3H]squalene-2, 3-oxide into the intact cells.
I Shechter, A M Fogelman, G Popják
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Mevalonic Acid Kinase in Euglena gracilis [PDF]
Plant Physiology, 1967 The isolation and partial purification of mevalonic acid kinase from Euglena gracilis is described. The product of the reaction MVA-5-P has been characterized by paper chromatography. The apparent Km values for l-mevalonic acid, ATP, and Mg(2+) are 3 x 10(-5)m, 6 x 10(-3)m, and 9 x 10(-3)m, respectively.
C Z, Cooper, C R, Benedict
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