Results 41 to 50 of about 10,880 (220)

Effect of mevalonate analogues upon cholesterol biosynthesis

open access: yesJournal of Lipid Research, 1961
Three analogues of mevalonic acid have been found to inhibit cholesterol biosynthesis in liver homogenates in the following order of efficacy: 3-methyl-3-hydroxy pentanoic acid > Δ2-3-methyl pentenoic acid > Δ3-3-methyl pentenoic acid.
Herbert Weiss   +2 more
doaj   +1 more source

An interstrain difference in cholesterol synthesis in vitro in mice, dependent upon a difference in endogenous NADPH-generating capacity

open access: yesJournal of Lipid Research, 1972
Earlier experiments have shown that significantly more endogenously generated NADPH is available for reduction of corticosterone in liver homogenates from C57BL/10 male mice than in those from the DBA/2 strain.
Felicia Gaskin, R.B. Clayton
doaj   +1 more source

Combined transcriptome and proteome analysis of Bcfrp1 involved in regulating the biosynthesis of abscisic acid and growth in Botrytis cinerea TB-31

open access: yesFrontiers in Microbiology, 2023
IntroductionAbscisic acid (ABA) is an important sesquiterpene compound that regulates the stress resistance of plants. Botrytis cinerea can synthesize ABA via the mevalonic acid pathway.
Dongbo Chen   +8 more
doaj   +1 more source

METABOLISM OF MEVALONIC ACID BY LACTOBACILLUS PLANTARUM [PDF]

open access: yesJournal of Bacteriology, 1964
Durr , I. F. (American University of Beirut, Beirut, Lebanon), and A. N. Shwayri . Metabolism of mevalonic acid by Lactobacillus plantarum . J. Bacteriol. 88: 361–366. 1964.— Lactobacillus plantarum strain 8014-H 2
I F, DURR, A N, SHWAYRI
openaire   +2 more sources

Group IVC cytosolic phospholipase A2γ is farnesylated and palmitoylated in mammalian cells

open access: yesJournal of Lipid Research, 2005
Cytosolic phospholipase A2γ (cPLA2γ) is a member of the group IV family of intracellular phospholipase A2 enzymes, but unlike the well-studied cPLA2α, it is constitutively bound to membrane and is calcium independent.
Dawn E. Tucker   +6 more
doaj   +1 more source

Sir John and Lady Rita Cornforth: a distinguished chemical partnership [PDF]

open access: yes, 2015
This review describes the life of Sir John Cornforth AC CBE FRS, who was awarded the Nobel Prize for Chemistry in 1975. It covers his early life in Australia, his work in Oxford, the National Institute for Medical Research, the Milstead Laboratory of ...
Battersby Sir Alan   +3 more
core   +1 more source

Interaction Between Mevalonate Pathway and Retinoic Acid‐Induced Differentiation [PDF]

open access: yesBioMed Research International, 2001
All trans retinoic acid (ATRA) is a potent inducer of differentiation of HL‐60 cell line. The pretreatment of the cells by compactin, a competitive inhibitor of 3‐hydroxy‐3‐methylglutaryl (HMG) CoA reductase, during 24 hours, enhances the ATRA‐induced cell differentiation.
Gueddari-Pouzols, Naima   +4 more
openaire   +2 more sources

Investigations on some metabolites of Tecoma stans Juss. callus tissue. Part II. Chromatographical analysis of alkaloid and quinone compounds

open access: yesActa Societatis Botanicorum Poloniae, 2015
Tecoma stans Juss. callus tissue grown on Murashige-Mei Lie Lin (M-L) and Murashige-Skoog (RT-k) medium supplemented with Tecoma alkaloid precursors like lysine, mevalonic acid lactone and quinolinic acid, were investigated for their alkaloid content by ...
Barbara Dohnal
doaj   +1 more source

Autoinflammatory syndromes: diagnosis and management [PDF]

open access: yes, 2010
During the last decades the description of autoinflammatory syndromes induced great interest among the scientific community. Mainly rheumatologists, immunologists and pediatricians are involved in the discovery of etiopathogenesis of these syndromes and ...
Sara De Sanctis   +7 more
core   +2 more sources

Mevalonate kinase deficiencies: from mevalonic aciduria to hyperimmunoglobulinemia D syndrome

open access: yesOrphanet Journal of Rare Diseases, 2006
Mevalonic aciduria (MVA) and hyperimmunoglobulinemia D syndrome (HIDS) represent the two ends of a clinical spectrum of disease caused by deficiency of mevalonate kinase (MVK), the first committed enzyme of cholesterol biosynthesis.
Hoffmann Georg F, Haas Dorothea
doaj   +1 more source

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