Results 41 to 50 of about 5,897 (180)
Clinical Genetics, EarlyView.Genetic hepatic cholestasis: NGS diagnostic yield. Over a 10‐year period, NGS (gene panel/WES) established a genetic diagnosis in 70% of 66 families with hepatic cholestasis, with a molecular yield of 62%. ABCB11 was the most mutated gene, and PFIC Type 2 was the leading diagnosis, underscoring the critical role of NGS in guiding genetic counseling and
Amal Abdmouleh +12 more
wiley +1 more source
Diverse genetic error modes constrain large-scale bio-based production
Nature Communications, 2018 The declining performance of scale-up bioreactor cultures is commonly attributed to phenotypic and physical heterogeneities. Here, the authors reveal multiple recurring intra-pathway error modes that limit engineered E.
Peter Rugbjerg +4 more
doaj +1 more source
Molecules, 2019 Ent-homocyclopiamine B (1), a new prenylated indole alkaloid bearing an alicyclic nitro group along with 2-methylbutane-1,2,4-triol (2) were isolated from an endophytic fungus Penicillium concentricum of the liverwort Trichocolea tomentella ...
Tehane Ali +3 more
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Plant, Cell &Environment, EarlyView.ABSTRACT Plants are dynamic chemical factories that produce diverse specialised metabolites essential for growth, defence, and environmental adaptation. Metabolomes, shaped by genetic architecture, enable plants to respond to abiotic and biotic pressures, including temperature fluctuations.
Refiloe M. M. Motsatsi +3 more
wiley +1 more source
Turnover of cholesteryl esters of plasma lipoproteins in the rat
Journal of Lipid Research, 1967 Turnover of individual classes of cholesteryl esters (classified on the basis of the degree of unsaturation of the fatty acid moiety) in rat plasma lipoproteins and liver was studied after the administration of mevalonic acid-5-3H and mevalonic acid-2 ...
Lewis I. Gidez +2 more
doaj +1 more source
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.The primary function of statins is to inhibit cholesterol synthesis, which contributes to their antidiabetic effects. However, the majority of the diabetic effects of statins are due to inhibition of isoprenoid synthesis. Atorvastatin, simvastatin and rosuvastatin possess the most pronounced diabetogenic properties. In contrast, lovastatin, fluvastatin,
Ali Nosrati Andevari, Mohsen Koolivand
wiley +1 more source
Journal of Lipid Research, 1974 Hepatic sterol synthesis is accelerated in animals after a single dose of allylisopropylacetamide, a chemical known to be porphyrogenic. Evidence is provided to show that enhanced sterol biosynthesis is due to an increased formation of mevalonic acid ...
Luigi Taddeini +2 more
doaj +1 more source
METABOLISM OF MEVALONIC ACID BY LACTOBACILLUS PLANTARUM [PDF]
Journal of Bacteriology, 1964 Durr , I. F. (American University of Beirut, Beirut, Lebanon), and A. N. Shwayri . Metabolism of mevalonic acid by Lactobacillus plantarum . J. Bacteriol. 88: 361–366. 1964.— Lactobacillus plantarum strain 8014-H 2
I F, DURR, A N, SHWAYRI
openaire +2 more sources
eFood, Volume 7, Issue 4, August 2026.Physapubescin B may interfere with multiple cancer‐associated signaling pathways by inhibiting Ras/Raf/mitogen‐activated protein kinase kinase/extracellular signal‐regulated kinase (Ras/Raf/MEK/ERK) signaling and vascular endothelial growth factor (VEGF)‐dependent angiogenesis.
Wojciech Koch +11 more
wiley +1 more source
iMeta, Volume 5, Issue 4, August 2026.From ecological principles to precision engineering of plant microbiomes for sustainable agriculture. The plant holobiont integrates diverse microbial niches (including rhizosphere, endosphere, phyllosphere, seed, and aerial‐root mucilagesphere), host genetics (namely M genes), and host metabolites. Furthermore, molecular dialogues, including rhizobial
Mi Wei +26 more
wiley +1 more source