Results 61 to 70 of about 6,314 (218)
A Plant‐Based Platform for the Production of Bark Beetle Pheromones
ABSTRACT Bark beetle species of the genera Ips and Dendroctonus represent a threat to forests in both North America and Europe. Under normal circumstances, these beetles recycle dying trees into nutrients, but under certain conditions, growing populations can overcome healthy tree defenses and cause severe economic loss in forestry.
Abraham Ontiveros‐Cisneros +7 more
wiley +1 more source
Periodic fever syndrome with mevalonate kinase deficiency, also known as hyperimmunoglobulinemia D syndrome, is characterized by early onset and relatively benign course.
Yu. S. Patrusheva, M. D. Bakradze
doaj +1 more source
The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...
Wen Zhang +7 more
wiley +1 more source
Mevalonic Acid Reverses Statin-Induced, but Not FTI-1-Induced, sAPPα Shedding
SweAPP N2a cells were treated for 24 h with simvastatin (Sim, 1 μM), FTI-1 (5 μM), mevalonic acid (0–100 μM), or combinations as indicated. Levels of sAPPα were evaluated by western blot as described in Methods.
Sam Gandy (6210) +5 more
core +1 more source
Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS
We have developed a new sensitive and specific nonradioisotope assay method to measure the activity of HMG-CoA reductase, the rate-controlling enzyme in the cholesterol biosynthetic pathway.
Honda Akira +5 more
doaj +1 more source
ABSTRACT In this study, bioassay‐guided fractionation of the ethanolic extract from Eremanthus crotonoides leaves enabled the isolation of two bioactive sesquiterpene lactones, centratherin and goyazensolide, which were evaluated for their antimycobacterial and anti‐inflammatory properties.
Natalie Giovanna da Rocha Ximenes +7 more
wiley +1 more source
Bioassay-guided fractionation of antibacterial extracts from cultures of a basidiomycete from Northern Thailand, which represents a new species of the genus Deconica, yielded the terpenoid deconin A (1), whose structure was elucidated by spectral methods
Benjarong Thongbai (1612969) +5 more
core +1 more source
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi +2 more
wiley +1 more source
Enhanced Metabolite Productivity of Escherichia coli Adapted to Glucose M9 Minimal Medium
High productivity of biotechnological strains is important to industrial fermentation processes and can be constrained by precursor availability and substrate uptake rate.
Peter Rugbjerg +3 more
doaj +1 more source
Green‐lipped mussel (Perna canaliculus) aquaculture is vulnerable to environmental changes, which are increasingly being studied to pinpoint physiological, economic and ecological threats. This study utilised a targeted liquid chromatography‐mass spectrometry metabolomics approach, focusing on the central carbon metabolism, to examine the metabolic ...
Leonie Venter +6 more
wiley +1 more source

