Results 61 to 70 of about 6,314 (218)

A Plant‐Based Platform for the Production of Bark Beetle Pheromones

open access: yesPlant Biotechnology Journal, Volume 24, Issue 4, Page 2442-2456, April 2026.
ABSTRACT Bark beetle species of the genera Ips and Dendroctonus represent a threat to forests in both North America and Europe. Under normal circumstances, these beetles recycle dying trees into nutrients, but under certain conditions, growing populations can overcome healthy tree defenses and cause severe economic loss in forestry.
Abraham Ontiveros‐Cisneros   +7 more
wiley   +1 more source

PERIODIC FEVER SYNDROME (MEVALONATE KINASE DEFICIENCY, HYPERIMMUNOGLOBULINEMIA D SYNDROME) IN CHILDREN

open access: yesВопросы современной педиатрии, 2012
Periodic fever syndrome with mevalonate kinase deficiency, also known as hyperimmunoglobulinemia D syndrome, is characterized by early onset and relatively benign course.
Yu. S. Patrusheva, M. D. Bakradze
doaj   +1 more source

Harnessing nanomaterials to precisely regulate the immunosuppressive tumor microenvironment for enhanced immunotherapy

open access: yesBMEMat, Volume 4, Issue 1, March 2026.
The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...
Wen Zhang   +7 more
wiley   +1 more source

Mevalonic Acid Reverses Statin-Induced, but Not FTI-1-Induced, sAPPα Shedding

open access: yes, 2013
SweAPP N2a cells were treated for 24 h with simvastatin (Sim, 1 μM), FTI-1 (5 μM), mevalonic acid (0–100 μM), or combinations as indicated. Levels of sAPPα were evaluated by western blot as described in Methods.
Sam Gandy (6210)   +5 more
core   +1 more source

Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS

open access: yesJournal of Lipid Research, 2007
We have developed a new sensitive and specific nonradioisotope assay method to measure the activity of HMG-CoA reductase, the rate-controlling enzyme in the cholesterol biosynthetic pathway.
Honda Akira   +5 more
doaj   +1 more source

Antimycobacterial and Nitric Oxide Production Inhibitory Activities of Goyazensolide and Centratherin Isolated From Eremanthus crotonoides by High‐Speed Countercurrent Chromatography

open access: yesChemistry &Biodiversity, Volume 23, Issue 3, March 2026.
ABSTRACT In this study, bioassay‐guided fractionation of the ethanolic extract from Eremanthus crotonoides leaves enabled the isolation of two bioactive sesquiterpene lactones, centratherin and goyazensolide, which were evaluated for their antimycobacterial and anti‐inflammatory properties.
Natalie Giovanna da Rocha Ximenes   +7 more
wiley   +1 more source

Deconins A–E: Cuparenic and Mevalonic or Propionic Acid Conjugates from the Basidiomycete Deconica sp. 471

open access: yes, 2015
Bioassay-guided fractionation of antibacterial extracts from cultures of a basidiomycete from Northern Thailand, which represents a new species of the genus Deconica, yielded the terpenoid deconin A (1), whose structure was elucidated by spectral methods
Benjarong Thongbai (1612969)   +5 more
core   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

open access: yesMedicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi   +2 more
wiley   +1 more source

Enhanced Metabolite Productivity of Escherichia coli Adapted to Glucose M9 Minimal Medium

open access: yesFrontiers in Bioengineering and Biotechnology, 2018
High productivity of biotechnological strains is important to industrial fermentation processes and can be constrained by precursor availability and substrate uptake rate.
Peter Rugbjerg   +3 more
doaj   +1 more source

Metabolic Dynamics of Central Carbon Pathways in Green‐Lipped Mussels under Heat Stress and Subsequent Recovery

open access: yesNew Zealand Journal of Marine and Freshwater Research, Volume 60, Issue 1, March 2026.
Green‐lipped mussel (Perna canaliculus) aquaculture is vulnerable to environmental changes, which are increasingly being studied to pinpoint physiological, economic and ecological threats. This study utilised a targeted liquid chromatography‐mass spectrometry metabolomics approach, focusing on the central carbon metabolism, to examine the metabolic ...
Leonie Venter   +6 more
wiley   +1 more source

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