Results 81 to 90 of about 10,880 (220)

Production of plasma esterified cholesterol in lean, normotriglyceridemic humans

Journal of Lipid Research, 1974
The rate of production of plasma esterified cholesterol was measured both in vivo and in vitro in seven subjects and in vivo alone in eight subjects. All subjects were lean, clinically healthy, and had triglyceride concentrations < 1.5 μmoles/ml. In vivo
Philip J. Barter
doaj   +1 more source

Statins in Breast Cancer Therapy: Mechanistic Insights and Emerging Evidence

Cancer Innovation, Volume 5, Issue 1, February 2026.
Statins, particularly simvastatin, demonstrate potential as adjuvant agents in breast cancer treatment by disrupting tumour cell signalling and survival pathways. This review highlights emerging evidence supporting their repurposing for improved outcomes, especially in aggressive breast cancer subtypes.
Rohina Alim, H. M. Kasuni Akalanka
wiley   +1 more source

Genetic engineering and molecular characterization of yeast strain expressing hybrid human-yeast squalene synthase as a tool for anti-cholesterol drug assessment [PDF]

, 2016
AIMS: The main objective of the study is molecular and biological characterization of the human-yeast hybrid squalene synthase (SQS), as a promising target for treatment of hypercholesterolaemia.
Burzynska, Beata, Danikiewicz, Witold, Gora, Monika, Kapur, S., Komaszylo, Joanna, Leszczynska, Agata, Maciejak, Agata, Plochocka, Danuta, Sojka, M., Swiezewska, Ewa, Tułacz, Dorota, Warchol, I., Wysocka-Kapcinska, Monika   +12 more
core   +1 more source

Effects of Basal Leaf Removal and Cluster Thinning on Monoterpene Accumulation and the Expression of Terpene Biosynthesis Genes in Ripening Moscato Bianco Grape Berries

Australian Journal of Grape and Wine Research, Volume 2026, Issue 1, 2026.
Background and Aims Monoterpenes are key contributors to the aromatic profile of Moscato Bianco grapes and wines. In recent years, producers in the Asti DOCG area (northwestern Italy) have reported a decline in grape aromatic intensity. This study aimed to evaluate whether canopy management practices, basal leaf removal and cluster thinning, can modify
Eleonora Littarru, Margherita Modesti, Giacomo Palai, Guido Bezzo, Giovanna Maggiorotto, Monica Ribaldone, Stefania Garberoglio, Daniele Eberle, Pietro Tonutti, Stefano Brizzolara, Paul Petrie   +10 more
wiley   +1 more source

Molecular Characterization of Trypanosoma evansi Mevalonate Kinase (TeMVK)

Frontiers in Cellular and Infection Microbiology, 2018
The mevalonate pathway is an essential part of isoprenoid biosynthesis leading to production of a diverse class of >30,000 biomolecules including cholesterol, heme, and all steroid hormones.
Daniel P. Duarte, Éden R. Ferreira, Fabio M. Lima, Fabio M. Lima, Franciane Batista, Michel De Groote, Eduardo Horjales, Luiz C. Miletti, Diana Bahia   +8 more
doaj   +1 more source

Inhibition of geranylgeranyl diphosphate synthesis in in vitro systems [PDF]

, 1985
The incorporation of [14C]mevalonate and [14C]isopentenyl diphosphate into geranylgeranyl diphosphate was investigated in in vitro systems from Cucurbita pepo (pumpkin) endosperm and from Avena sativa etioplasts.
Mitzka-Schnabel, Ursula, Rau, Werner, Rüdiger, Wolfhart, Soll, Jürgen, Steiger, Andrea   +4 more
core   +1 more source

Review of Biological Agents in the Therapeutic Management of Monogenic Genodermatoses

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Monogenic genodermatoses encompass a diverse group of over 400 distinct disorders, presenting significant therapeutic challenges. Recent advancements in the clinical application of biological agents have heralded a new era in the management of these conditions.
Xueying Wang, Qing Zhao, Hong Liu, Furen Zhang, Zhiqiang Song   +4 more
wiley   +1 more source

Metabolic engineering of Escherichia coli for the utilization of ethanol

Journal of Biological Research - Thessaloniki, 2020
Background The fuel ethanol industry has made tremendous progress in the last decades. Ethanol can be obtained by fermentation using a variety of biomass materials as the feedstocks.
Yujin Cao, Hui Mu, Jing Guo, Hui Liu, Rubing Zhang, Wei Liu, Mo Xian, Huizhou Liu   +7 more
doaj   +1 more source

Morphologic and Biochemical Changes in Dogs After Portacaval Shunt Plus Bile Fistula or Ileal Bypass: Failure of Bile Fistula or Ileal Bypass to Prevent Hepatocyte Atrophy [PDF]

, 1983
External biliary fistula (BF) or ileal bypass (IB) was performed in dogs at the time of or 2 weeks after portacaval shunt (PCS). The pathologic changes in the dog livers 2 to 4 weeks later were compared to those caused by PCS alone.
Francavilla, A, Hayashida, N, Mcnamara, DJ, Parker, TS, Porter, KA, Russell, WJI, Starzl, TE, Thompson, JS   +7 more
core   +1 more source

Action Mechanism of Essential Oils or Their Components Against Pathogenic Bacteria: Literature Review

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
Essential oils (EOs), derived from medicinal and aromatic plants, are natural mixtures of volatile, oily compounds with varying compositions and antibacterial mechanisms. Understanding the mechanisms of EOs and their components (EOCs) is essential for predicting their impacts on various microbes and their interactions with antibiotics.
Mohamed A. El-Sakhawy, Abd El Raheim Mohammed Donia, Tawfiq N. Juraybi, Abeer Ali El-Sherbiny Ateya, Wadah Osman, Amr A. Abd-Elghany, Mohamed Mostafa Soliman, Abdel Naser A. Kobisi, Mohamed A. Balah, Shweta Negi   +9 more
wiley   +1 more source