THE BIOSYNTHESIS OF MEVALONIC ACID [PDF]
Proceedings of the National Academy of Sciences, 1959 J J, Ferguson, I F, Durr, H, Rudney
openaire +4 more sources
Mevalonic Acid Kinase in Euglena gracilis [PDF]
Plant Physiology, 1967 The isolation and partial purification of mevalonic acid kinase from Euglena gracilis is described. The product of the reaction MVA-5-P has been characterized by paper chromatography. The apparent Km values for l-mevalonic acid, ATP, and Mg(2+) are 3 x 10(-5)m, 6 x 10(-3)m, and 9 x 10(-3)m, respectively.
C Z, Cooper, C R, Benedict
openaire +2 more sources
Mevalonate metabolism by renal tissue in vitro
Journal of Lipid Research, 1974 Previous studies from this laboratory have demonstrated that the kidneys rather than the liver play the major role in the in vivo metabolism of circulating mevalonic acid.
Philip Raskin, Marvin D. Siperstein
doaj +1 more source
Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in KrasG12D mice. [PDF]
, 2019 We examined the impact of statins on Yes-associated Protein (YAP) localization, phosphorylation and transcriptional activity in human and mouse pancreatic ductal adenocarcinoma (PDAC) cells.
Chang, Hui-Hua +7 more
core +2 more sources
Urinary excretion of mevalonic acid as an indicator of cholesterol synthesis
Journal of Lipid Research, 1996 Urinary excretion of mevalonic acid was investigated as an indicator of cholesterol synthesis. In normolipemic volunteers, excretion of mevalonic acid averaged 3.51 +/- 0.59 (SD) micrograms/kg x day1; (n = 24) and was not different from patients with ...
B Lindenthal +5 more
doaj +1 more source
, 2019 The aging process includes impairment in mitochondrial function, a reduction in anti-oxidant activity, and an increase in oxidative stress, marked by an increase in reactive oxygen species (ROS) production.
Barcelos, Isabella Peixoto de +1 more
core +1 more source
Statin-induced myopathic changes in primary human muscle cells and reversal by a prostaglandin F2 alpha analogue [PDF]
, 2020 Statin-related muscle side effects are a constant healthcare problem since patient compliance is dependent on side effects. Statins reduce plasma cholesterol levels and can prevent secondary cardiovascular diseases.
Dittmar, Gunnar +10 more
core +1 more source
Biotropia: The Southeast Asian Journal of Tropical Biology, 2011 Effect on callus growth was studied for Citrus grandis cultured with feeding of exogenous mevalonic acid (MVA) at concentrations of 0.04, 0.08, 0.38, 0.77, 1.15 and 1.54 mM.
ZARINA ZAKARIA +2 more
doaj +1 more source
Impact of Obesity and MASH on Zonal Hepatocellular Statin Exposure: Pharmacodynamic Insights From a Permeability-Limited Multicompartment Liver Model. [PDF]
CPT Pharmacometrics Syst PharmacolObesity, MASH and Statins: Insights from a PBPK/PD Zonal Liver Model. ABSTRACT Statins are frequently prescribed for hyperlipidemia, a common comorbidity in patients with obesity and/or metabolic dysfunction‐associated steatohepatitis (MASH). However, limited knowledge exists on how MASH may alter statin disposition within hepatocytes where the statin ...
Murphy WA +5 more
europepmc +2 more sources
Inhibition of cholesterol biogenesis by arsenite: preparation of labeled lanosterol*
Journal of Lipid Research, 1961 When mevalonic acid-2-C14 was incubated with rat liver homogenate with the usual cofactors plus 10−3 M arsenite, the formation of labeled cholesterol was inhibited and labeled lanosterol accumulated.
Mary L. Moller, T.T. Tchen
doaj +1 more source