Results 31 to 40 of about 1,076 (129)
FEBS Open Bio, Volume 5, Issue 1, Page 325-334, January 01, 2015., 2015 The 1‐deoxy‐d‐xylulose‐5‐phosphate reductoisomerase (DXR; EC1.1.1.267), an NADPH‐dependent reductase, plays a pivotal role in the methylerythritol 4‐phosphate pathway (MEP), in the conversion of 1‐deoxy‐d‐xylulose‐5‐phosphate (DXP) into MEP.
Kamalakshi Devi +4 more
wiley +1 more source
Inhibition of human mevalonate kinase by allosteric inhibitors of farnesyl pyrophosphate synthase
FEBS Open Bio, Volume 14, Issue 8, Page 1320-1339, August 2024.Mevalonate kinase constitutes a key regulatory step in the mevalonate pathway, an established drug target for its role in the synthesis of isoprenoid molecules. Using a structure‐based rational approach, we identified several synthetic compounds that inhibit mevalonate kinase with nanomolar potency.
Saman Salari +3 more
wiley +1 more source
Neuroprotection, Volume 2, Issue 2, Page 151-166, June 2024.This systematic review provides valuable insights into the neuroprotective and antioxidant effects of steroids and ecdysteroids on the human neuroblastoma SH‐SY5Y cells, highlighting their potential as therapeutic agents for neurodegenerative disorders characterized by oxidative stress.
Bizhar Ahmed Tayeb +2 more
wiley +1 more source
SYNTHESIS AND EVALUATION OF SOME ARYLALKENYL AND ARYLEPOXYALKYL HYDROGEN SUCCINATES AND HYDROGEN GLUTARATES AS INHIBITORS OF RAT LIVER β-HYDROXY-β-METHYLGLUTARYL COENZYME A REDUCTASE [PDF]
, 1974 Atherosclerotic disease is an almost universal phenomenon and increases in severity and frequency with increasing age. Atherosclerosis may contribute to several disorders including bursting of an artery, blockage of an artery, or induction of arterial ...
Marecki, Paul Emil
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Advanced Materials, Volume 36, Issue 5, February 1, 2024.This review focuses on multienzyme cascades for the biosynthesis of novel compounds and how nanomaterials can potentially improve their efficiency. Recent successes in applying biosynthetic strategies for multi‐step, one‐pot reactions toward novel products of interest are highlighted.
Shelby L. Hooe +5 more
wiley +1 more source
Ornamental plants, 1979: a summary of research [PDF]
, 1979 An analysis of production costs for containerized nursery products / David E. Hahn, Jerry L. Robertson, and Elton M. Smith -- Monoterpene investigations with creeping juniper cultivars (Juniperus horizontalis Moench.) / Thomas A.
Chatfield, J. A. +14 more
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Biosynthesis of bile acids [PDF]
, 1968 Cholesterol, along with a number of its derivatives and very small quantities of its precursors, is the only sterol which can be identified in extracts of mammalian tissue.
Percy-Robb, Iain Walter
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Structural features and domain movements controlling substrate binding and cofactor specificity in class II HMG-CoA reductase [PDF]
, 2018 The key mevalonate pathway enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR) uses the cofactor NAD(P)H to reduce HMG-CoA to mevalonate in the production of countless metabolites and natural products.
Kung, Yan, Miller, Bradley R
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On the Biosynthesis of Irregular Terpenes: Mechanistic Studies Employing the Thiamine Thiazole as an Isoprenoid Analogue. [PDF]
, 1981 The irregular terpene, 2,6,9,13-tetramethyl-6-vinyl-tetradeca-2,8,12-trien-7-one (18), and the terpenoid, 1-phenyl-2,6-dimethyl-2-vinyl-hept-5-en-1-one (19) were synthesized by the Continuous Flow Reformatsky method using geranoyl chloride and benzoyl ...
Jungk, Steven J
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Biosynthetic Studies of Natural Plant Products: The Biosynthesis of Petasin in Petasites hybridus (L) Compositae [PDF]
, 1970 In recent years, the study of natural products has undergone a shift in emphasis from the classical, purely structural type of chemical investigation to consideration of the relationship of such compounds with the organism of origin.
Keates, Robert Anthony Butler
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