MGluR5 mediates the interaction between late-LTP, network activity, and learning. [PDF]
PLoS ONE, 2008 Hippocampal synaptic plasticity and learning are strongly regulated by metabotropic glutamate receptors (mGluRs) and particularly by mGluR5. Here, we investigated the mechanisms underlying mGluR5-modulation of these phenomena.
Arthur Bikbaev +5 more
doaj +8 more sources
Intracellular mGluR5 plays a critical role in neuropathic pain [PDF]
Nature Communications, 2016 mGluR5 has been shown to play a role in chronic pain regulation. Here, the authors use membrane permeable and non-transported, impermeable mGluR5 antagonists to show that spinal analgesic effects in vivoare mediated by intracellular rather than cell ...
Kathleen Vincent +10 more
doaj +8 more sources
Reduced mGluR5 Activity Modulates Mitochondrial Function [PDF]
Cells, 2021 The metabotropic glutamate receptor 5 (mGluR5) is an essential modulator of synaptic plasticity, learning and memory; whereas in pathological conditions, it is an acknowledged therapeutic target that has been implicated in multiple brain disorders ...
Miguel A. Gonzalez-Lozano +5 more
doaj +5 more sources
mGluR5 Knockout mice exhibit normal conditioned place-preference to cocaine [PDF]
, 2012 Metabotropic glutamate receptor 5 (mGluR5) null mutant (-/-) mice have been reported to totally lack the rein- forcing or locomotor stimulating effects of cocaine. We tested mGluR5 -/- and +/+ mice for their locomotor and conditioned place- preference response to cocaine.
Andrew L. Varnell +2 more
arxiv +4 more sources
Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors [PDF]
British Journal of Pharmacology, 2005 Neuroprotection has been reported after either activation or blockade of the group I metabotropic glutamate receptor subtype 5 (mGluR5). However, some recent evidence suggests that protection provided by mGluR5 antagonists may reflect their ability to inhibit N‐methyl‐D‐aspartate (NMDA) receptor activity. Here, in both rat and mouse cortical neurons,
Paul M. Lea +2 more
openalex +4 more sources
Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity. [PDF]
PLoS ONE, 2010 Dementia with Lewy bodies (DLB) and Parkinson's Disease (PD) are neurodegenerative disorders of the aging population characterized by the abnormal accumulation of alpha-synuclein (alpha-syn).
Diana L Price +11 more
doaj +6 more sources
Intracellular mGluR5 can mediate synaptic plasticity in the hippocampus [PDF]
The Journal of Neuroscience, 2014 Metabotropic glutamate receptor 5 (mGluR5) is widely expressed throughout the CNS and participates in regulating neuronal function and synaptic transmission.
Izumi, Yukitoshi +5 more
core +7 more sources
Acute inhibition of mGluR5 disrupts behavioral flexibility [PDF]
Neurobiology of Learning and Memory, 2016 Conditioned cues can sometimes elicit maladaptive responses as seen in the post-traumatic stress disorder (PTSD). Lack of effective fear extinction, which involves a process of inhibitory learning, is hypothesized to associate with PTSD. In this study, we tested the effect of acute pharmacological inhibition of mGluR5 activity on the extinction of fear
Ferzin Sethna, Hongbing Wang
openalex +4 more sources
Cerebral mGluR5 availability contributes to elevated sleep need and behavioral adjustment after sleep deprivation [PDF]
eLife, 2017 Increased sleep time and intensity quantified as low-frequency brain electrical activity after sleep loss demonstrate that sleep need is homeostatically regulated, yet the underlying molecular mechanisms remain elusive.
Sebastian C Holst +11 more
doaj +3 more sources
Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5). [PDF]
PLoS ONE, 2010 Pharmacological and genetic studies have suggested that the metabotropic glutamate receptor 5 (mGluR5) is critically involved in mediating the reinforcing effects of drugs of abuse, but not food. The purpose of this study was to use mGluR5 knockout (KO),
Christopher M Olsen +3 more
doaj +6 more sources