Intracellular mGluR5 plays a critical role in neuropathic pain [PDF]
Nature Communications, 2016 mGluR5 has been shown to play a role in chronic pain regulation. Here, the authors use membrane permeable and non-transported, impermeable mGluR5 antagonists to show that spinal analgesic effects in vivoare mediated by intracellular rather than cell ...
Kathleen Vincent +10 more
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Reduced mGluR5 Activity Modulates Mitochondrial Function [PDF]
Cells, 2021 The metabotropic glutamate receptor 5 (mGluR5) is an essential modulator of synaptic plasticity, learning and memory; whereas in pathological conditions, it is an acknowledged therapeutic target that has been implicated in multiple brain disorders ...
Miguel A. Gonzalez-Lozano +5 more
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MGluR5 mediates the interaction between late-LTP, network activity, and learning. [PDF]
PLoS ONE, 2008 Hippocampal synaptic plasticity and learning are strongly regulated by metabotropic glutamate receptors (mGluRs) and particularly by mGluR5. Here, we investigated the mechanisms underlying mGluR5-modulation of these phenomena.
Arthur Bikbaev +5 more
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mGluR5 knockout mice exhibit normal conditioned place-preference to cocaine [PDF]
, 2011 Metabotropic glutamate receptor 5 (mGluR5) null mutant (-/-) mice have been reported to totally lack the reinforcing or locomotor stimulating effects of cocaine.
Donald Cooper +3 more
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Cerebral mGluR5 availability contributes to elevated sleep need and behavioral adjustment after sleep deprivation [PDF]
eLife, 2017 Increased sleep time and intensity quantified as low-frequency brain electrical activity after sleep loss demonstrate that sleep need is homeostatically regulated, yet the underlying molecular mechanisms remain elusive.
Sebastian C Holst +11 more
doaj +3 more sources
Increased mGluR5 in somatostatin-positive interneurons mediates deactivation of the mPFC in a mouse model of neuropathic pain [PDF]
Experimental and Molecular MedicineUnderstanding the neurobiological alterations associated with neuropathic pain is crucial for treatment interventions, but the underlying mechanisms remain unclear.
Mirae Jang +8 more
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Enhanced mGluR5 intracellular activity causes psychiatric alterations in Niemann Pick type C disease [PDF]
Cell Death and DiseaseNiemann-Pick disease Type C (NPC) is caused by mutations in the cholesterol transport protein NPC1 leading to the endolysosomal accumulation of the lipid and to psychiatric alterations.
Ana Toledano-Zaragoza +9 more
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Cells, 2022 Group I metabotropic glutamate receptors (mGluRs) include mGluR1 and mGluR5, which are coupled to the Gq family of heterotrimeric G-proteins and readily activated by their selective agonist 3,5-dihydroxyphenilglycine (DHPG).
Maria Harbers +8 more
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Scientific Reports, 2022 Glutamate receptors, including mGluR5, are involved in learning and memory impairments triggered by aging and neurological diseases. However, each condition involves distinct molecular mechanisms.
Jessica M. de Souza +7 more
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Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity. [PDF]
PLoS ONE, 2010 Dementia with Lewy bodies (DLB) and Parkinson's Disease (PD) are neurodegenerative disorders of the aging population characterized by the abnormal accumulation of alpha-synuclein (alpha-syn).
Diana L Price +11 more
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