Results 101 to 110 of about 17,143 (247)
Regulation of Amyloid Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex [PDF]
, 2016 The prion protein (PrPC) has been suggested to operate as a scaffold/receptor protein in neurons, participating in both physiological and pathological associated events. PrPC, laminin, and metabotropic glutamate receptor 5 (mGluR5) form a protein complex
Beraldo, Flavio H. +13 more
core +2 more sources
Aging Cell, Volume 24, Issue 5, May 2025.We show that genetic and pharmacological inhibition of the metabotropic glutamate receptor, DmGluRA extends Drosophila lifespan, improves stress tolerance and alters early‐life locomotion. Several markers indicative of reduced ribosomal biogenesis, a hallmark of longevity, were also detected in these flies.
Cui Guan +4 more
wiley +1 more source
PolyMorphine provides extended analgesic-like effects in mice with spared nerve injury. [PDF]
, 2017 Morphine is a well-characterized and effective analgesic commonly used to provide pain relief to patients suffering from both acute and chronic pain conditions.
Chen, Renxun +5 more
core +1 more source
CNS Neuroscience &Therapeutics, Volume 31, Issue 5, May 2025.To summarize and analyze the general clinical manifestations, laboratory tests, electroencephalography and imaging characteristics, treatment and prognosis of 88 patients with anti‐leucine‐rich glioma inactivated protein 1 antibody encephalitis (LGI1‐AE) at baseline, discharge, and follow‐up in China, aiming to identify risk factors affecting disease ...
Yang Zhao +13 more
wiley +1 more source
Chronic Stress, 2023 Metabotropic glutamate receptor 5 (mGluR5) dysregulation has been implicated in the pathophysiology of many psychiatric disorders, as well as nicotine use and dependence.
Stephen R. Baldassarri +6 more
doaj +1 more source
The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex [PDF]
, 2017 Metabotropic glutamate receptor 5 (mGluR5) activation in the infralimbic cortex (IL) induces pronociceptive behavior in healthy and monoarthritic rats.
Pereira, Ana Carla David +5 more
core +3 more sources
International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 23-30, April 2025.Abstract Autoimmune encephalitis is a group of disorders characterized by symptoms of dysfunction of the limbic and extra‐limbic systems that occur in association with antibodies against intracellular antigens, synapses, or proteins located on the surface of nerve cells. Anti‐NMDA (N‐methyl‐D‐aspartate) receptor encephalitis was first described in 2007
Pham Ba Nha +6 more
wiley +1 more source
The Journal of Headache and Pain, 2020 Background The mechanism of chronic migraine (CM) is complex, central sensitization is considered as one of the pathological mechanism. Synaptic plasticity is the basis of central sensitization.
Yingying Niu +8 more
doaj +1 more source
A Prolyl-Isomerase Mediates Dopamine-Dependent Plasticity and Cocaine Motor Sensitization [PDF]
, 2013 SummarySynaptic plasticity induced by cocaine and other drugs underlies addiction. Here we elucidate molecular events at synapses that cause this plasticity and the resulting behavioral response to cocaine in mice.
Datko, Michael C. +15 more
core +1 more source
Journal of Neurochemistry, Volume 169, Issue 4, April 2025.This study examines how breast cancer and psychological stress impact the hippocampal proteome, uncovering altered signalling pathways linked to mitochondrial dysfunction, impaired energy production, and altered synaptic plasticity; that is, cellular processes that are critical for memory formation and cognitive health.
Myrthe Mampay +6 more
wiley +1 more source