Results 101 to 110 of about 17,948 (248)

Nicotine Use and Metabotropic Glutamate Receptor 5 in Individuals With Major Depressive and Posttraumatic Stress Disorders

Chronic Stress, 2023
Metabotropic glutamate receptor 5 (mGluR5) dysregulation has been implicated in the pathophysiology of many psychiatric disorders, as well as nicotine use and dependence.
Stephen R. Baldassarri, Ruth H. Asch, Ansel T. Hillmer, Robert H. Pietrzak, Nicole DellaGioia, Irina Esterlis, Margaret T. Davis   +6 more
doaj   +1 more source

The association of spinophilin with disks large-associated protein 3 (SAPAP3) is regulated by metabotropic glutamate receptor (mGluR) 5 [PDF]

, 2018
Spinophilin is the most abundant protein phosphatase 1 targeting protein in the postsynaptic density of dendritic spines. Spinophilin associates with myriad synaptic proteins to regulate normal synaptic communication; however, the full complement of ...
Baucum, Anthony J., II, Edler, Michael C., Morris, Cameron W., Salek, Asma B., Watkins, Darryl S.   +4 more
core   +1 more source

Early intervention combined with targeted treatment promotes cognitive and behavioral improvements in young children with fragile x syndrome. [PDF]

, 2012
Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability due to an expansion in the full mutation range (>200 CGG repeats) of the promoter region of the FMR1 gene leading to gene silencing.
Borodyanskara, Mariya, Hagerman, Randi J, Schneider, Andrea, Winarni, Tri Indah   +3 more
core   +3 more sources

Prenatal Exposure to Lipopolysaccharide or Valproate Leads to Abnormal Accumulation of the NMDA Receptor Agonist D‐Aspartate in the Adolescent Rat Brain

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
Autism spectrum disorder (ASD) is a neurodevelopmental condition linked to glutamatergic neurotransmission abnormalities. We analyzed by HPLC the cerebral and peripheral profiles of D‐aspartate, D‐serine, and other L‐amino acids involved in NMDA receptor signaling in environmental ASD rat models prenatally exposed to lipopolysaccharide or valproate ...
Anna Di Maio, Isar Yahyavi, Valeria Buzzelli, Zoraide Motta, Fabrizio Ascone, Lorenza Putignani, Alessandro Usiello, Loredano Pollegioni, Viviana Trezza, Francesco Errico   +9 more
wiley   +1 more source

Metabotropic glutamate receptor 5 regulates synaptic plasticity in a chronic migraine rat model through the PKC/NR2B signal

The Journal of Headache and Pain, 2020
Background The mechanism of chronic migraine (CM) is complex, central sensitization is considered as one of the pathological mechanism. Synaptic plasticity is the basis of central sensitization.
Yingying Niu, Xiaoxu Zeng, Lilin Zhao, Yang Zhou, Guangcheng Qin, Dunke Zhang, Qingqing Fu, Jiying Zhou, Lixue Chen   +8 more
doaj   +1 more source

Oxygen/Glucose deprivation induces a reduction in synaptic AMPA receptors on hippocampal CA3 neurons mediated by mGluR1 and adenosine A3 receptors [PDF]

, 2011
Hippocampal CA1 pyramidal neurons are highly sensitive to ischemic damage, whereas neighboring CA3 pyramidal neurons are less susceptible. It is proposed that switching of AMPA receptor (AMPAR) subunits on CA1 neurons during an in vitro model of ischemia,
Cimarosti, Helena, Dennis, Siobhan, Hanley, Jonathan G., Henley, Jeremy M., Jaafari, Nadia, Mellor, Jack R.   +5 more
core   +1 more source

Rethinking Sensory Information Processing: The Essential Role of Astrocytes

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
In this review, we discuss recent advances highlighting the emerging roles of astrocytes in sensory information processing. We review how astrocytes are anatomically integrated within distinct sensory systems, how they are activated by specific external stimuli, and how their modulation influences the output of sensory neurons to shape behavioral ...
Juliana M. Rosa, Juan Aguilar
wiley   +1 more source

Critical role of canonical transient receptor potential channel 7 in initiation of seizures [PDF]

, 2014
Status epilepticus (SE) is a life-threatening disease that has been recognized since antiquity but still causes over 50,000 deaths annually in the United States.
Abramowitz, J., Birnbaumer, Lutz, Phelan, K. D., Shwe, U. T., Zheng, F.   +4 more
core   +1 more source

Disentangling the Switching Behavior in Functional Connectivity Dynamics in Autism Spectrum Disorder: Insights from Developmental Cohort Analysis and Molecular‐Cellular Associations

Advanced Science, Volume 12, Issue 20, May 29, 2025.
A region‐wise functional connectivity dynamics (FCD) switching index (RFSI) identifies abnormal drivers in ASD across development, linked to salience/ventral attention, default mode, and frontoparietal networks. RFSI changes correlate with transcriptomic and neurotransmitter profiles, and supported by gene‐edited ASD monkeys.
Wei Li, Xia Qiu, Jin Chen, Kexuan Chen, Meiling Chen, Yinyan Wang, Wenjie Sun, Jing Su, Yongchang Chen, Xiaobao Liu, Congying Chu, Jiaojian Wang   +11 more
wiley   +1 more source

RETRACTED ARTICLE: mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia

Molecular Psychiatry, 2018
Multiple lines of evidence point to glutamatergic signaling in the postsynaptic density (PSD) as a pathophysiologic mechanism in schizophrenia. Integral to PSD glutamatergic signaling is reciprocal interplay between GluN and mGluR5 signaling. We examined agonist-induced mGluR5 signaling in the postmortem dorsolateral prefrontal cortex (DLPFC) derived ...
Andrew Tom, Amber Khan, Kuo-Chieh Lee, Mathew L. MacDonald, Patrick M. A. Sleiman, Raquel E. Gur, Scott E. Hemby, Chang-Gyu Hahn, Warren B. Bilker, Panos Roussos, Karin E. Borgmann-Winter, Karin E. Borgmann-Winter, Anamika Banerjee, Steven J. Siegel, Hoau-Yan Wang   +14 more
openaire   +4 more sources