Results 101 to 110 of about 20,586 (243)

Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice

Aging Cell, Volume 25, Issue 2, February 2026.
Comprehensive transcriptomic profiling of eight mouse organs across six ages reveals how aging reshapes biological processes. Trajectory and network analyses distinguish shared and organ‐specific signatures, charting the molecular landscape of systemic aging.
Sarah Morsy, Enzo Scifo, Kan Xie, Kristina Schaaf, Jenny Russ, Stefan Paulusch, Elena De Domenico, Paolo Salomoni, Daniele Bano, Dan Ehninger   +9 more
wiley   +1 more source

Metabotropic glutamate receptor 5 as a potential target for smoking cessation [PDF]

, 2016
Rationale Most habitual smokers find it difficult to quit smoking because they are dependent upon the nicotine present in tobacco smoke. Tobacco dependence is commonly treated pharmacologically using nicotine replacement therapy or drugs, such as ...
A Auber, A Markou, A Markou, A Markou, A Markou, AA Harrison, AJ Severance, AK Stoker, AL Milton, AL Milton, AR Caggiula, AR Caggiula, AW Ary, AY Bespalov, B Xiao, C Cadoni, C Chiamulera, C Romano, CA Heidbreder, CA Owesson-White, CJ Swanson, Claudio Marcello Marzo, CM Niswender, Cristiano Chiamulera, CW Hodge, D Hustonlyons, D Lecca, D Li, D Martinez, David J. K. Balfour, DH Malin, DJ Balfour, DJ Balfour, DJ Balfour, E Luccini, EL Kam van der, F Akkus, F Akkus, F Ferraguti, F Gasparini, F Nicoletti, FI Carroll, GN Pachas, HH Nickols, HS Crombag, JA O’Brien, JE Rose, JE Rose, JF Cryan, JH Kim, JM Arnold, JP Schroeder, JR Hughes, JT Gass, KK Szumlinski, L Hou, L Mu, LH Brauer, LM Hulka, M Louis, M Olive, M Parodi, M Tessari, MA Bozarth, MB Ghasemzadeh, ME Benwell, ME Liechti, ME Liechti, ME Liechti, MG LeSage, MI Palmatier, MI Palmatier, MP Epping-Jordan, MPH Osborne, MS D’Souza, MS Milella, MT Taber, N Chaudhri, N Chaudhri, ND Cosford, NE Paterson, NE Paterson, P Backstrom, P Welsby, PB Clarke, PBS Clarke, PJ Kenny, PJ Kenny, PR Brakeman, PW Kalivas, PW Kalivas, PW Kalivas, R Anwyl, R Rong, R Shigemoto, RD Peavy, RE Nordquist, RJ Cormier, RK Das, RL Pillai, RM Brown, RW Gould, S Kawabata, SA Kotecha, SA McKee, SB Floresco, SJ Tallaksen-Greene, SM Ametamey, SM Ametamey, T Agren, T Zhang, TM Keck, TM Marton, V Kumaresan, V Tedesco, V Tronci, V Tronci, VC Wing, X Li, X Liu, ZP Jia   +120 more
core   +2 more sources

The Calcium‐Binding Protein S100A10 (p11) Is Required for Normal Motor Performance by Regulating Vesicle Dynamics at Excitatory Synapses

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Aim Identifying interactors in sensorimotor processing and neurotransmission remains a current challenge for understanding neural information processing and brain function. Methods To evaluate the role of p11 in sensorimotor processing and excitatory synaptic neurotransmission, neuron‐specific lentivirus‐directed p11 silencing, small ...
Esther Vilches‐Herrando, Guillermo Rodríguez‐Bey, Rosendo G. Hernández, Ángela Gento‐Caro, Ángel M. Pastor, Antonio Campos‐Caro, David González‐Forero, Bernardo Moreno‐López   +7 more
wiley   +1 more source

Controlled trial of lovastatin combined with an open-label treatment of a parent-implemented language intervention in youth with fragile X syndrome. [PDF]

, 2020
BackgroundThe purpose of this study was to conduct a 20-week controlled trial of lovastatin (10 to 40 mg/day) in youth with fragile X syndrome (FXS) ages 10 to 17 years, combined with an open-label treatment of a parent-implemented language intervention (
Abbeduto, Leonard, Banasik, Amy, Bullard, Lauren, Hagerman, Randi, Kim, Kyoungmi, McDuffie, Andrea, Nguyen, Vivian, Potter, Laura A, Potter, Sarah Nelson, Tassone, Flora, Thurman, Angela John   +10 more
core  

Dissociable effects of mGluR5 allosteric modulation on distinct forms of impulsivity in rats: interaction with NMDA receptor antagonism [PDF]

, 2013
Rationale: Impaired N-methyl-D-aspartate (NMDA) receptor signalling underlies several psychiatric disorders that express high levels of impulsivity. Although synergistic interactions exist between NMDA receptors and metabotropic glutamate receptor 5 ...
Isherwood, Sarah N, Pekcec, Anton, Nicholson, Janet R, Robbins, Trevor, Dalley, Jeffrey   +4 more
core   +1 more source

Glutamate Delta 1 Receptor in Synapses, Circuits, and Disease

European Journal of Neuroscience, Volume 63, Issue 3, February 2026.
This review discusses our current understanding of the structure–function, expression and roles in neural circuits of the less studied glutamate delta 1 (GluD1) receptor. Converging data suggests many unique features of GluD1 including expression at both excitatory and inhibitory synapses and binding to D‐serine and GABA.
Diane Choi, Poojashree B. Chettiar, Yoland Smith, Shashank M. Dravid   +3 more
wiley   +1 more source

The role of metabotropic glutamate receptor 5 in the pathogenesis of mood disorders and addiction:Combining preclinical evidence with human Positron Emission Tomography (PET) studies

Frontiers in Neuroscience, 2015
In the present review, we deliver an overview of the involvement of metabotropic glutamate receptor 5 (mGluR5) activity and density in pathological anxiety, mood disorders and addiction.
Sylvia eTerbeck, Funda eAkkus, Laurence Paul Chesterman, Gregor eHasler   +3 more
doaj   +1 more source

Group 1 metabotropic glutamate receptors 1 and 5 form a protein complex in mouse hippocampus and cortex [PDF]

, 2016
The group 1 metabotropic glutamate receptors 1 and 5 (mGluR1/5) have been implicated in mechanisms of synaptic plasticity and may serve as potential therapeutic targets in autism spectrum disorders.
Houtsmuller, A.B. (Adriaan), Klaassen, R.V. (Remco V.), Li, K.W. (Ka Wan), Pandya, N.J. (Nikhil J.), Slotman, J.A. (Johan A.), Smit, A.B. (August), van der Schors, R.C. (Roel C.)   +6 more
core   +1 more source

Astrocyte Regulation of Spinal Circuit Function

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Spinal cord astrocytes exist as an additional component of the computational framework that governs both sensory perceptions and motor outputs (left). By integrating local synaptic activity together with signals that reflect whole‐body state (e.g., neuromodulators, immune signals, and vascular signals) into defined input states (Sn), astrocytes adapt ...
Mary Kaye Duff, Min Jun Li, Axel Nimmerjahn   +2 more
wiley   +1 more source

Alcohol addiction: a molecular biology perspective. [PDF]

, 2015
Alcohol misuse represents worldwide an important risk factor for death and disability. Excessive alcohol consumption is widely diffused in different ethnicities and alcohol use is part of the lifestyle of both young and old people.
Ferraguti, Giampiero, Lucarelli, Marco, Pascale, Esterina   +2 more
core   +1 more source