A molecular perspective on mGluR5 regulation in the antidepressant effect of ketamine
Pharmacological ResearchKetamine, a non-competitive N-methyl-D-aspartate receptor (NMDAR) antagonist, has received much attention for its rapid antidepressant effects. A single administration of ketamine elicits rapid and sustained antidepressant effects in both humans and animals.
Elmeseiny, Ola Sobhy A. +1 more
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Pharmacological and Anatomical Evidence for an Interaction Between mGluR5- and GABAA α1-Containing Receptors in the Discriminative Stimulus Effects of Ethanol [PDF]
, 2004 Joyce Besheer, Clyde W. Hodge
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Phosphorylation State-Dependent Regulation of SAPAP3 and mGluR5 Association [PDF]
, 2015 poster abstractThis study aims to characterize the interaction between SAP90/PSD-95-associated protein 3 (SAPAP3) and metabotropic Glutamate Receptor 5 (mGluR5); specifically focusing on how SAPAP3 phosphorylation state modulates association. SAPAP3 is a
Baucum, A.J. +2 more
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Astrocytes Control Neuronal Excitability in the Nucleus Accumbens
The Scientific World Journal, 2007 Though accumulating evidence shows that the metabotropic glutamate receptor 5 (mGluR5) mediates some of the actions of extracellular glutamate after cocaine use, the cellular events underlying this action are poorly understood.
Tommaso Fellin +2 more
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Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP [PDF]
, 2005 Qijiang Yan +3 more
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BMC NeurologyBackground There are very limited reports on anti-metabolic glutamate receptor5 (mGluR5) encephalitis, especially lacking of pediatric research. The disease was mostly accompanied by tumors, mainly Hodgkin's lymphoma.
Kaili Shi +4 more
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The RNA Binding Protein TLS Is Translocated to Dendritic Spines by mGluR5 Activation and Regulates Spine Morphology [PDF]
, 2005 Ritsuko Fujii +8 more
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NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin [PDF]
, 2005 Sudar Alagarsamy +5 more
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Metabotropic Glutamate 5 Receptor (mGluR5) Antagonists Decrease Nicotine Seeking, But Do Not Affect the Reinforcement Enhancing Effects of Nicotine [PDF]
, 2007 Matthew I. Palmatier +4 more
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