Results 171 to 180 of about 20,152 (283)

Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: Unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold [PDF]

, 2008
Sameer Sharma, Alice L. Rodriguez, P. Jeffrey Conn, Craig W. Lindsley   +3 more
openalex   +1 more source

Enhanced binding of metabotropic glutamate receptor type 5 (mGluR5) PET tracers in the brain of parkinsonian primates [PDF]

, 2008
Rosario Sánchez‐Pernaute, J.-Q. Wang, Darshini Kuruppu, Li Cao, W. TUECKMANTEL, Alan P. Kozikowski, Ole Isacson, Anna‐Liisa Brownell   +7 more
openalex   +1 more source

Voltage-independent SK-channel dysfunction causes neuronal hyperexcitability in the hippocampus of Fmr1 knock-out mice [PDF]

, 2019
Neuronal hyperexcitability is one of the major characteristics of fragile X syndrome (FXS), yet the molecular mechanisms of this critical dysfunction remain poorly understood. Here we report a major role of voltage-independent potassium (
Carlin, Dan, Cavalli, Valeria, Deng, Pan-Yue, Klyachko, Vitaly A, Myrick, Leila K, Oh, Young Mi, Warren, Stephen T   +6 more
core   +1 more source

Using DREADD to Examine the Role of Infralimbic Gq-coupled Receptors in Fear Acquisition

, 2019
Post-Traumatic Stress Disorder (PTSD) can develop after a person experiences a very traumatic event that produces a strong and long-lasting aversive memory. During any given year, approximately 8 million adults will suffer from PTSD.
Haddock Martínez, Héctor A., Hernández-López, Anixa, Porter, Ph.D., James   +2 more
core  

Metabotropic glutamate receptor 5 may be involved in macrophage plasticity

Biological Research
Background Macrophages are a functionally heterogeneous cell population and depending on microenvironments they polarize in two main groups: M1 and M2. Glutamic acid and glutamate receptors may participate in the regulation of macrophage plasticity.
Lali Shanshiashvili, Elene Tsitsilashvili, Nino Dabrundashvili, Irine Kalandadze, David Mikeladze   +4 more
doaj   +1 more source

Dynamin 3 Is a Component of the Postsynapse, Where it Interacts with mGluR5 and Homer

, 2003
Noah W. Gray, Lawrence Fourgeaud, Bing Huang, Jing Chen, Hong Cao, Barbara Oswald, Agnès Hémar, Mark A. McNiven   +7 more
openalex   +1 more source

mGluR5 Positive Allosteric Modulators Facilitate both Hippocampal LTP and LTD and Enhance Spatial Learning [PDF]

, 2009
Jennifer Ayala, Yelin Chen, Jessica L. Banko, Douglas J. Sheffler, Richard D. Williams, Alexandra N Telk, Noreen L Watson, Zixiu Xiang, Yongqin Zhang, Paulianda J. Jones, Craig W. Lindsley, M. Foster Olive, P. Jeffrey Conn   +12 more
openalex   +1 more source

Role of protein kinase C epsilon (PKCɛ) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell [PDF]

, 2009
Justin T. Gass, M. Foster Olive
openalex   +1 more source

Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5 [PDF]

, 2010
Marianne Renner, Pascale N. Lacor, Pauline T. Velasco, Jian Xu, Anis Contractor, William L. Klein, Antoine Triller   +6 more
openalex   +1 more source

The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice

, 2005
Clyde W. Hodge, Michael F. Miles, Amanda C. Sharko, Rebekah A. Stevenson, Jennie R. Hillmann, Veronique Lepoutre, Joyce Besheer, Jason P. Schroeder   +7 more
openalex   +2 more sources