Results 181 to 190 of about 17,948 (248)

Tau pathology is associated with postsynaptic metabotropic glutamate receptor 5 (mGluR5) in early Alzheimer's disease in a sex-specific manner. [PDF]

Alzheimers Dement
Wang Y, Wang J, Chen X, Lin Z, You Z, He K, Guo T, Zhao J, Huang Q, Ni R, Guan Y, Li B, Xie F.   +12 more
europepmc   +1 more source

Anti-metabotropic glutamate receptor 5 coexistent anti-N-methyl-D-aspartate receptor encephalitis: a case report and literature review. [PDF]

Front Immunol
Gu Y, Xuan T, Li P, Zhou J, Wang Z.
europepmc   +1 more source

Chronic Inflammatory Pain Impairs mGluR5-Mediated Depolarization-Induced Suppression of Excitation in the Anterior Cingulate Cortex [PDF]

, 2017
Baolin Guo, Jiaqi Wang, Han Yao, Keke Ren, Jing Chen, Jing Yang, Guohong Cai, Haiying Liu, Yunlong Fan, Wenting Wang, Shengxi Wu   +10 more
openalex   +1 more source

Astragalin relieves inflammatory pain and negative mood in CFA mice by down-regulating mGluR5 signaling pathway. [PDF]

Sci Rep
Zhang R, Lin J, Wang S, Yang C, Zhou C, Yang Y, Liu J, Jin X, Zhang L, Ma Y.   +9 more
europepmc   +1 more source

A Phase I randomized clinical trial testing the safety, tolerability and preliminary pharmacokinetics of the mGluR5 negative allosteric modulator GET 73 following single and repeated doses in healthy volunteers [PDF]

, 2017
Carolina L. Haass‐Koffler, Kimberly Goodyear, Victoria M. Long, Harrison H. Tran, Antonella Loche, Roberto Cacciaglia, Robert M. Swift, Lorenzo Leggio   +7 more
openalex   +1 more source

Inhibition of metabotropic glutamate receptor-5 alleviates hepatic steatosis by enhancing autophagy <i>via</i> activation of the AMPK signaling pathway. [PDF]

World J Gastroenterol
Tao M, Zhang LL, Zhou GH, Wang C, Luo X.
europepmc   +1 more source

Effect of the mGluR5-NAM Basimglurant on Behavior in Adolescents and Adults with Fragile X Syndrome in a Randomized, Double-Blind, Placebo-Controlled Trial: FragXis Phase 2 Results [PDF]

, 2017
Eriene Youssef, Elizabeth Berry‐Kravis, Christian Czech, Randi J. Hagerman, David Hessl, Chin Wong, Michael Rabbia, Dennis Deptula, Amy John, Russell Kinch, Philip Drewitt, Lothar Lindemann, Moritz Marcinowski, Rachel Langland, Carsten Horn, Paulo Fontoura, Luca Santarelli, Jorge A. Quiroz   +17 more
openalex   +1 more source

mGluR5-mediated astrocytes hyperactivity in the anterior cingulate cortex contributes to neuropathic pain in male mice. [PDF]

Commun Biol
Shen W, Chen F, Tang Y, Zhao Y, Zhu L, Xiang L, Ning L, Zhou W, Chen Y, Wang L, Li J, Huang H, Zeng LH.   +12 more
europepmc   +1 more source

Erratum to “Potent mGluR5 antagonists: Pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series” [Bioorg. Med. Chem. Lett. 21 (2011) 3243–3247]

, 2012
David Alagille, Herve DaCosta, Yelin Chen, Ruedee Hemstapat, Alice L. Rodriguez, Ronald M. Baldwin, P. Jeffrey Conn, Gilles Tamagnan   +7 more
openalex   +1 more source

Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice [PDF]

, 2017
Elisabetta Aloisi, Katy Le Corf, Julien P. Dupuis, Pei Zhang, Melanie Ginger, Virginie Labrousse, Michela Spatuzza, Matthias G. Haberl, Lara Costa, Ryuichi Shigemoto, Anke Tappe‐Theodor, Filippo Drago, Pier Vincenzo Piazza, Christophe Mulle, Laurent Groc, Lucia Ciranna, Maria Vincenza Catania, Andreas Frick   +17 more
openalex   +1 more source