Results 11 to 20 of about 17,143 (247)

Acute Alcohol‐Induced Changes Measured With Metabotropic Glutamate Receptor 5 Positron Emission Tomography [PDF]

Addiction Biology, Volume 30, Issue 5, May 2025.
This proof‐of‐concept study provides evidence that acute alcohol administration reduces mGluR5 availability and increases relative blood flow in the human brain, as measured by [11C]ABP688 PET. The observed effects align with preclinical evidence of alcohol‐induced glutamate release.
Nakul R. Raval, Kelly Smart, Gustavo A. Angarita, Rachel Miller, Yiyun Huang, John H. Krystal, Richard E. Carson, Kelly P. Cosgrove, Stephanie S. O'Malley, Ansel T. Hillmer   +9 more
wiley   +2 more sources

Tau pathology is associated with postsynaptic metabotropic glutamate receptor 5 (mGluR5) in early Alzheimer's disease in a sex-specific manner [PDF]

Alzheimers Dement
INTRODUCTION To investigate the associations of metabotropic glutamate receptor 5 (mGluR5) with tau deposition and cognitive ability in patients with early Alzheimer's disease (AD).
Chen, Xing, Guan, Yihui, Guo, Tengfei, He, Kun, Huang, Qi, Li, Binyin, Lin, Zengping, Ni, Ruiqing, Wang, Jie, Wang, Yan, Xie, Fang, You, Zhiwen, Zhao, Jun   +12 more
core   +2 more sources

Enhanced mGluR5 intracellular activity causes psychiatric alterations in Niemann Pick type C disease [PDF]

Cell Death and Disease
Niemann-Pick disease Type C (NPC) is caused by mutations in the cholesterol transport protein NPC1 leading to the endolysosomal accumulation of the lipid and to psychiatric alterations.
Ana Toledano-Zaragoza, Violeta Enriquez-Zarralanga, Sara Naya-Forcano, Víctor Briz, Rocío Alfaro-Ruíz, Miguel Parra-Martínez, Daniel N. Mitroi, Rafael Luján, José A. Esteban, María Dolores Ledesma   +9 more
doaj   +2 more sources

Increased mGluR5 in somatostatin-positive interneurons mediates deactivation of the mPFC in a mouse model of neuropathic pain [PDF]

Experimental and Molecular Medicine
Understanding the neurobiological alterations associated with neuropathic pain is crucial for treatment interventions, but the underlying mechanisms remain unclear.
Mirae Jang, Jaegeon Lee, Seung Ha Kim, Sang Ho Yoon, Myoung-Hwan Kim, Yong-Seok Lee, Sun Kwang Kim, Geehoon Chung, Sang Jeong Kim   +8 more
doaj   +2 more sources

Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice [PDF]

, 2017
Metabotropic glutamate receptor subtype 5 (mGluR5) is crucially implicated in the pathophysiology of Fragile X Syndrome (FXS); however, its dysfunction at the sub-cellular level, and related synaptic and cognitive phenotypes are unexplored.
Elisabetta Aloisi, Katy Le Corf, Julien P. Dupuis, Pei Zhang, Melanie Ginger, Virginie Labrousse, Michela Spatuzza, Matthias G. Haberl, Lara Costa, Ryuichi Shigemoto, Anke Tappe‐Theodor, Filippo Drago, Pier Vincenzo Piazza, Christophe Mulle, Laurent Groc, Lucia Ciranna, Maria Vincenza Catania, Andreas Frick   +17 more
openalex   +6 more sources

Presynaptic density determined by SV2A PET is closely associated with postsynaptic metabotropic glutamate receptor 5 availability and independent of amyloid pathology in early cognitive impairment [PDF]

Alzheimers Dement
INTRODUCTION: Metabotropic glutamate receptor 5 (mGluR5) is involved in regulating integrative brain function and synaptic transmission. Aberrant mGluR5 signaling and relevant synaptic failure play a key role in the pathophysiological mechanism of ...
Guan, Yihui, Guo, Qihao, Guo, Tengfei, He, Kun, Huang, Qi, Huang, Yiyun, Li, Binying, Li, Junpeng, Li, Songye, Lin, Zengping, Ni, Ruiqing, Van Laere, Koen, Vanderlinden, Greet, Wang, Jie, Xie, Fang, Yang, Yang   +15 more
core   +2 more sources

mGluR5 Is Substitutable for mGluR1 in Cerebellar Purkinje Cells for Motor Coordination, Developmental Synapse Elimination, and Motor Learning

Cells, 2022
Group I metabotropic glutamate receptors (mGluRs) include mGluR1 and mGluR5, which are coupled to the Gq family of heterotrimeric G-proteins and readily activated by their selective agonist 3,5-dihydroxyphenilglycine (DHPG).
Maria Harbers, Harumi Nakao, Takaki Watanabe, Kyoko Matsuyama, Shoichi Tohyama, Kazuki Nakao, Yasushi Kishimoto, Masanobu Kano, Atsu Aiba   +8 more
doaj   +1 more source

mGluR5 ablation leads to age-related synaptic plasticity impairments and does not improve Huntington’s disease phenotype

Scientific Reports, 2022
Glutamate receptors, including mGluR5, are involved in learning and memory impairments triggered by aging and neurological diseases. However, each condition involves distinct molecular mechanisms.
Jessica M. de Souza, Talita H. Ferreira-Vieira, Esther M. A. Maciel, Nathalia C. Silva, Izabella B. Quirino Lima, Juliana G. Doria, Isabella G. Olmo, Fabiola M. Ribeiro   +7 more
doaj   +1 more source

Current updates of CRISPR/Cas9‐mediated genome editing and targeting within tumor cells: an innovative strategy of cancer management

Cancer Communications, Volume 42, Issue 12, Page 1257-1287, December 2022., 2022
Abstract Clustered regularly interspaced short palindromic repeats‐associated protein (CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust, accurate, efficient and programmable method for genome targeting and editing. This innovative and revolutionary technique can play a significant role in animal modeling, in vivo genome
Khaled S. Allemailem, Mohammed A Alsahli, Ahmad Almatroudi, Faris Alrumaihi, Fahd Khaleefah Alkhaleefah, Arshad Husain Rahmani, Amjad Ali Khan   +6 more
wiley   +1 more source

Preso1, mGluR5 and the machinery of pain [PDF]

Nature Neuroscience, 2012
By bringing mGluR1/5 and proline-directed kinases together, the scaffold protein Preso1 stabilizes the interaction between mGluR1/5 and Homer. This mechanism may attenuate calcium influx into spinal neurons and reduce pain.
Natalie C. Tronson, Jelena Radulovic
openaire   +3 more sources