mGluR5 as a Potential Orchestrator of Astrocyte Interactions in Neurological Disorders [PDF]
Neural PlasticityAstrocytes and metabotropic glutamate receptor 5 (mGluR5) have emerged as pivotal regulators of synaptic homeostasis and neural communication within the central nervous system (CNS).
Jeongseop Kim +4 more
doaj +4 more sources
Cerebral mGluR5 availability contributes to elevated sleep need and behavioral adjustment after sleep deprivation [PDF]
eLife, 2017 Increased sleep time and intensity quantified as low-frequency brain electrical activity after sleep loss demonstrate that sleep need is homeostatically regulated, yet the underlying molecular mechanisms remain elusive.
Sebastian C Holst +11 more
doaj +5 more sources
Intracellular mGluR5 plays a critical role in neuropathic pain [PDF]
Nature Communications, 2016 mGluR5 has been shown to play a role in chronic pain regulation. Here, the authors use membrane permeable and non-transported, impermeable mGluR5 antagonists to show that spinal analgesic effects in vivoare mediated by intracellular rather than cell ...
Kathleen Vincent +10 more
doaj +7 more sources
Reduced mGluR5 Activity Modulates Mitochondrial Function [PDF]
Cells, 2021 The metabotropic glutamate receptor 5 (mGluR5) is an essential modulator of synaptic plasticity, learning and memory; whereas in pathological conditions, it is an acknowledged therapeutic target that has been implicated in multiple brain disorders ...
Miguel A. Gonzalez-Lozano +5 more
doaj +6 more sources
Activation of mGluR5 and NMDA Receptor Pathways in the Rostral Ventrolateral Medulla as a Central Mechanism for Methamphetamine-Induced Pressor Effect in Rats [PDF]
Biomolecules, 2020 Acute hypertension produced by methamphetamine (MA) is well known, mainly by the enhancement of catecholamine release from sympathetic terminals. However, the central pressor mechanism of the blood-brain-barrier-penetrating molecule remains unclear.
Chih-Chia Lai +4 more
doaj +2 more sources
mGluR5 ablation leads to age-related synaptic plasticity impairments and does not improve Huntington’s disease phenotype [PDF]
Scientific Reports, 2022 Glutamate receptors, including mGluR5, are involved in learning and memory impairments triggered by aging and neurological diseases. However, each condition involves distinct molecular mechanisms.
Jessica M. de Souza +7 more
doaj +2 more sources
Characterizing Spatial Associations Between GluCEST MRI and Neurotransmitter Receptor Density in the Human Cortex. [PDF]
Hum Brain MappWe leveraged in vivo 7T GluCEST MRI and normative PET receptor maps to examine the spatial covariation between cortical glutamate levels and receptor expression. GluCEST signal showed positive spatial associations with NMDA and GABAA, but not mGluR5. These findings enhance our understanding of GluCEST and glutamate‐receptor dynamics across the cortex ...
Pecsok MK +17 more
europepmc +2 more sources
CHIMIA, 2012 Involvement of metabotropic glutamate receptor subtype 5 (mGluR5) in physiological and pathophysiological processes in the brain has been demonstrated, and hence mGluR5 has emerged as an important drug target. [11C]-ABP688 is clinically the most
Selena Milicevic Sephton +6 more
doaj +3 more sources
Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5). [PDF]
PLoS ONE, 2010 Pharmacological and genetic studies have suggested that the metabotropic glutamate receptor 5 (mGluR5) is critically involved in mediating the reinforcing effects of drugs of abuse, but not food. The purpose of this study was to use mGluR5 knockout (KO),
Christopher M Olsen +3 more
doaj +5 more sources
Increased mGluR5 in somatostatin-positive interneurons mediates deactivation of the mPFC in a mouse model of neuropathic pain [PDF]
Experimental and Molecular MedicineUnderstanding the neurobiological alterations associated with neuropathic pain is crucial for treatment interventions, but the underlying mechanisms remain unclear.
Mirae Jang +8 more
doaj +2 more sources