Results 11 to 20 of about 17,948 (248)

Intracellular mGluR5 can mediate synaptic plasticity in the hippocampus [PDF]

The Journal of Neuroscience, 2014
Metabotropic glutamate receptor 5 (mGluR5) is widely expressed throughout the CNS and participates in regulating neuronal function and synaptic transmission.
Izumi, Yukitoshi, Jong, Yuh-Jin I, Kumar, Vikas, O\u27Malley, Karen L, Purgert, Carolyn A, Zorumski, Charles F   +5 more
core   +7 more sources

Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors [PDF]

British Journal of Pharmacology, 2005
Neuroprotection has been reported after either activation or blockade of the group I metabotropic glutamate receptor subtype 5 (mGluR5). However, some recent evidence suggests that protection provided by mGluR5 antagonists may reflect their ability to inhibit N‐methyl‐D‐aspartate (NMDA) receptor activity. Here, in both rat and mouse cortical neurons,
Paul M. Lea, Vilen Movsesyan, Alan I. Faden   +2 more
openalex   +4 more sources

mGluR5 in Pyramidal Neurons in the Hippocampus Mediates Chronic Stress-Induced Memory Deficits. [PDF]

CNS Neurosci Ther
Diagrammatic representation of the role of mGluR5 in controlling memory impairments brought on by chronic stress. Chronic stress caused memory impairment, decreased GABAergic synaptic inputs, and decreased mGluR5 and PACAP levels in the hippocampus CA1.
Lu HC, Du ZJ, Chen H, Guo T, Yang SC, Li X.   +5 more
europepmc   +2 more sources

Targeting Excitatory Glutamate Receptors for Morphine Tolerance: A Narrative Review. [PDF]

CNS Neurosci Ther
Schematic diagram for the excitatory glutamate receptors for morphine tolerance and drugs targeting glutamate receptors in morphine tolerance. This figure illustrates the main mechanisms by which the major ionic and metabotropic glutamatergic receptors are involved in the process of morphine tolerance.
Huang M, Luo L, Wang W, Xu H, Chen M, Ma X, Xu T.   +6 more
europepmc   +2 more sources

Preso1, mGluR5 and the machinery of pain [PDF]

Nature Neuroscience, 2012
By bringing mGluR1/5 and proline-directed kinases together, the scaffold protein Preso1 stabilizes the interaction between mGluR1/5 and Homer. This mechanism may attenuate calcium influx into spinal neurons and reduce pain.
Natalie C. Tronson, Jelena Radulovic
openaire   +3 more sources

PET imaging of mGluR5 in Alzheimer’s disease [PDF]

Alzheimer's Research & Therapy, 2020
Abstract Background Metabotropic glutamate subtype 5 receptors (mGluR5) modulate synaptic transmission and may constitute an important therapeutic target in Alzheimer’s disease (AD) by mediating the synaptotoxic action of amyloid-β oligomers.
Adam P. Mecca, Julia W. McDonald, Hannah R. Michalak, Tyler A. Godek, Joanna E. Harris, Erika A. Pugh, Emily C. Kemp, Ming-Kai Chen, Arash Salardini, Nabeel B. Nabulsi, Keunpoong Lim, Yiyun Huang, Richard E. Carson, Stephen M. Strittmatter, Christopher H. van Dyck   +14 more
openaire   +4 more sources

Encephalitis with mGluR5 antibodies [PDF]

Neurology, 2018
To report the clinical features of 11 patients with metabotropic glutamate receptor 5 (mGluR5) antibody-associated encephalitis, immunoglobulin G (IgG) subclass, and effects of the antibodies on neuronal mGluR5 clusters.Clinical information was retrospectively obtained from referring physicians.
Spatola, Marianna, Sabater, Lidia, Heaney, Nicholas, Tubridy, Niall, Munteis Olivas, Elvira, Rosenfeld, Myrna R, Graus, Francesc, Dalmau, Josep, Planagumà, Jesús, Martínez-Hernandez, Eugenia, Armangué, Thaís, Prüss, Harald, Iizuka, Takahiro, Caparó Oblitas, Ruben L, Antoine, Jean-Christophe, Li, Richard   +15 more
openaire   +4 more sources

mGluR5 stimulates gliotransmission in the nucleus accumbens [PDF]

Proceedings of the National Academy of Sciences, 2007
Although metabotropic glutamate receptor 5 (mGluR5) is essential for cocaine self-administration and drug-seeking behavior, there is limited knowledge of the cellular actions of this receptor in the nucleus accumbens (NAc). Although mGluR5 has the potential to regulate neurons directly, recent studies have shown the importance of mGluR5 in
D'Ascenzo, Marcello, Fellin, Tommaso, Terunuma, Miho, Revilla Sanchez, Raquel, Meaney, David F., Auberson, Yves P., Moss, Stephen J., Haydon, Philip G.   +7 more
openaire   +4 more sources

Acute inhibition of mGluR5 disrupts behavioral flexibility [PDF]

Neurobiology of Learning and Memory, 2016
Conditioned cues can sometimes elicit maladaptive responses as seen in the post-traumatic stress disorder (PTSD). Lack of effective fear extinction, which involves a process of inhibitory learning, is hypothesized to associate with PTSD. In this study, we tested the effect of acute pharmacological inhibition of mGluR5 activity on the extinction of fear
Ferzin Sethna, Hongbing Wang
openalex   +4 more sources

In vivo glucose metabolism and glutamate levels in mGluR5 knockout mice: a multimodal neuroimaging study using [18F]FDG microPET and MRS

EJNMMI Research, 2020
Background Perturbed functional coupling between the metabotropic glutamate receptor-5 (mGluR5) and N-methyl-d-aspartate (NMDA) receptor-mediated excitatory glutamatergic neurotransmission may contribute to the pathophysiology of psychiatric disorders ...
Yo-Han Joo, Yun-Kwan Kim, In-Gyu Choi, Hyeon-Jin Kim, Young-Don Son, Hang-Keun Kim, Paul Cumming, Jong-Hoon Kim   +7 more
doaj   +1 more source