Results 221 to 230 of about 20,586 (243)

NMDA-induced phosphorylation and regulation of mGluR5

Pharmacology Biochemistry and Behavior, 2002
Glutamate regulates neuronal function by acting on ionotropic receptors such as the N-methyl-D-aspartate (NMDA) receptor and metabotropic receptors (mGluRs). We have previously shown that low concentrations of NMDA are able to significantly potentiate mGluR5 responses via activation of a protein phosphatase and reversal of phosphorylation-induced ...
Sudar, Alagarsamy, Susan T, Rouse, Candace, Junge, G W, Hubert, David, Gutman, Yoland, Smith, P Jeffrey, Conn   +6 more
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Encephalitis associated with anti-mGluR5 antibodies

Practical Neurology
A 30-year-old woman had 5 days of visual hallucinations, nystagmus, memory impairment and mutism. On examination, she was disorientated with reduced attention span, gaze-evoked nystagmus, paratonia and abnormal frontal reflexes. Cerebrospinal fluid (CSF) showed 80 cells, protein 0.41 g/L and glucose 3.2 mmol/L (plasma glucose 5.0 mmol/L).
Denison Alves Pedrosa, João Henrique Fregadolli Ferreira, Rene Gleizer, Rafael Bernhart Carra, Rachel Marin de Carvalho, Verena Endmayr, Romana Hoftberger, Lívia Almeida Dutra   +7 more
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Azetidinyl oxadiazoles as potent mGluR5 positive allosteric modulators

Bioorganic & Medicinal Chemistry Letters, 2012
A novel series of aryl azetidinyl oxadiazoles are identified as mGluR5 positive allosteric modulators (PAMs) with improved physico-chemical properties. N-substituted cyclohexyl and exo-norbornyl carboxamides, and carbamate analogs of azetidines are moderate to potent mGluR5 PAMs.
Mathivanan, Packiarajan, Christine G Mazza, Ferreira, Sang-Phyo, Hong, Andrew D, White, Gamini, Chandrasena, Xiaosui, Pu, Robbin M, Brodbeck, Albert J, Robichaud   +7 more
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Reduced stress‐induced hyperthermia in mGluR5 knockout mice

European Journal of Neuroscience, 2002
AbstractIt hs been suggested that metabotropic glutamate receptor subtype 5 (mGluR5) play a role in the expression of anxiety, based on anxiolytic‐like effects of the selective mGluR5 antagonist MPEP (2‐methyl‐6‐(phenylethynyl)pyridine) in rodent models of anxiety, including stress‐induced hyperthermia (SIH).
J, Brodkin, M, Bradbury, C, Busse, N, Warren, L J, Bristow, M A, Varney   +5 more
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Imaging mGluR5 Dynamics in Astrocytes Using Quantum Dots

Current Protocols in Neuroscience, 2014
AbstractThis unit describes the method that we have developed to clarify endogenous mGluR5 (etabotropic tamate eceptors 5) dynamics in astrocytes by single‐particle tracking using quantum dots (QD‐SPT). QD‐SPT has been a powerful tool to examine the contribution of neurotransmitter receptor dynamics to synaptic plasticity.
Misa, Arizono, Hiroko, Bannai, Katsuhiko, Mikoshiba   +2 more
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Differential expression of mGluR5 in human lumbosacral motoneurons

NeuroReport, 2004
Glutamatergic excitotoxicity is one of the main hypotheses to explain motoneuronal degeneration in amyotrophic lateral sclerosis (ALS). Interestingly, autonomic motoneurons remain almost unaffected, even in late stages of the disease. Since glutamate receptors may mediate neurotoxic as well as neuroprotective effects, different expression patterns may ...
Johanna M H, Anneser, Paul G, Ince, Pamela J, Shaw, Gian Domenico, Borasio   +3 more
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Structural and molecular determinants regulating mGluR5 surface expression

Neuropharmacology, 2017
Trafficking of G protein-coupled receptors (GPCRs) to the plasma membrane is a pivotal process to fulfill their biological functions. Metabotropic glutamate receptors (mGluRs; mGluR1-8) are expressed throughout the CNS and are important for modulating synaptic transmission and plasticity.
Kai, Chang, Katherine W, Roche
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Structure–Activity Relationships for Negative Allosteric mGluR5 Modulators

ChemMedChem, 2012
AbstractA series of compounds based on the mGluR5‐selective ligand 2‐methyl‐6‐(phenylethynyl)pyridine (MPEP) were designed and synthesized. The compounds were found to be either structural analogues of MPEP, substituted monomers, or dimeric analogues. All compounds retained mGluR5 selectivity with only weak or no activity at other mGluRs or iGluRs. The
Kaae, Birgitte H, Harpsøe, Kasper, Kvist, Trine, Mathiesen, Jesper M, Mølck, Christina, Gloriam, David E, Jimenez, Hermogenes N, Uberti, Michelle A, Nielsen, Søren M, Nielsen, Birgitte, Bräuner-Osborne, Hans, Sauerberg, Per, Clausen, Rasmus Prætorius, Madsen, Ulf   +13 more
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Structure–activity relationship of thiopyrimidines as mGluR5 antagonists

Bioorganic & Medicinal Chemistry Letters, 2006
Structure-activity relationship investigations of the thiopyrimidine (1), an HTS hit with micromolar activity as a metabotropic glutamate receptor 5 (mGluR5) antagonist, led to compounds with sub-micromolar activity.
Lance G, Hammerland, Martin, Johansson, Jonas, Malmström, Jan P, Mattsson, Alexander B E, Minidis, Karolina, Nilsson, Alecia, Peterson, David, Wensbo, Andreas, Wållberg, Krister, Osterlund   +9 more
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Corticostriatal LTP requires combined mGluR1 and mGluR5 activation

Neuropharmacology, 2003
Metabotropic glutamate receptors (mGluRs) have been demonstrated to play a role in synaptic plasticity. It has been recently shown that mGluR1 is involved in corticostriatal long-term depression, by means of pharmacological approach and by using mGluR1-knockout mice.
Gubellini, P, Saulle, E, CENTONZE, DIEGO, Costa, C, Tropepi, D, BERNARDI, GIORGIO, Conquet, F, CALABRESI, PAOLO   +7 more
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