Results 21 to 30 of about 17,143 (247)

PET imaging of mGluR5 in Alzheimer’s disease [PDF]

Alzheimer's Research & Therapy, 2020
Abstract Background Metabotropic glutamate subtype 5 receptors (mGluR5) modulate synaptic transmission and may constitute an important therapeutic target in Alzheimer’s disease (AD) by mediating the synaptotoxic action of amyloid-β oligomers.
Adam P. Mecca, Julia W. McDonald, Hannah R. Michalak, Tyler A. Godek, Joanna E. Harris, Erika A. Pugh, Emily C. Kemp, Ming-Kai Chen, Arash Salardini, Nabeel B. Nabulsi, Keunpoong Lim, Yiyun Huang, Richard E. Carson, Stephen M. Strittmatter, Christopher H. van Dyck   +14 more
openaire   +4 more sources

Encephalitis with mGluR5 antibodies [PDF]

Neurology, 2018
To report the clinical features of 11 patients with metabotropic glutamate receptor 5 (mGluR5) antibody-associated encephalitis, immunoglobulin G (IgG) subclass, and effects of the antibodies on neuronal mGluR5 clusters.Clinical information was retrospectively obtained from referring physicians.
Spatola, Marianna, Sabater, Lidia, Heaney, Nicholas, Tubridy, Niall, Munteis Olivas, Elvira, Rosenfeld, Myrna R, Graus, Francesc, Dalmau, Josep, Planagumà, Jesús, Martínez-Hernandez, Eugenia, Armangué, Thaís, Prüss, Harald, Iizuka, Takahiro, Caparó Oblitas, Ruben L, Antoine, Jean-Christophe, Li, Richard   +15 more
openaire   +4 more sources

mGluR5 stimulates gliotransmission in the nucleus accumbens [PDF]

Proceedings of the National Academy of Sciences, 2007
Although metabotropic glutamate receptor 5 (mGluR5) is essential for cocaine self-administration and drug-seeking behavior, there is limited knowledge of the cellular actions of this receptor in the nucleus accumbens (NAc). Although mGluR5 has the potential to regulate neurons directly, recent studies have shown the importance of mGluR5 in
D'Ascenzo, Marcello, Fellin, Tommaso, Terunuma, Miho, Revilla Sanchez, Raquel, Meaney, David F., Auberson, Yves P., Moss, Stephen J., Haydon, Philip G.   +7 more
openaire   +4 more sources

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

British Journal of Pharmacology, EarlyView., 2023
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier   +6 more
wiley   +1 more source

Different Aberrant Changes of mGluR5 and Its Downstream Signaling Pathways in the Scrapie-Infected Cell Line and the Brains of Scrapie-Infected Experimental Rodents

Frontiers in Cell and Developmental Biology, 2022
Metabotropic glutamate receptor subtype 5 (mGluR5) is a G-protein-coupled receptor found widely in the central nervous system. It has been involved in the development and progression of some neurodegenerative diseases, but its role in prion diseases is ...
Chao Hu, Cao Chen, Cao Chen, Ying Xia, Jia Chen, Wei Yang, Lin Wang, Lin Wang, Dong-Dong Chen, Yue-Zhang Wu, Qin Fan, Xiao-Xi Jia, Kang Xiao, Qi Shi, Qi Shi, Zhi-Bao Chen, Xiao-Ping Dong, Xiao-Ping Dong, Xiao-Ping Dong, Xiao-Ping Dong   +19 more
doaj   +1 more source

In vivo glucose metabolism and glutamate levels in mGluR5 knockout mice: a multimodal neuroimaging study using [18F]FDG microPET and MRS

EJNMMI Research, 2020
Background Perturbed functional coupling between the metabotropic glutamate receptor-5 (mGluR5) and N-methyl-d-aspartate (NMDA) receptor-mediated excitatory glutamatergic neurotransmission may contribute to the pathophysiology of psychiatric disorders ...
Yo-Han Joo, Yun-Kwan Kim, In-Gyu Choi, Hyeon-Jin Kim, Young-Don Son, Hang-Keun Kim, Paul Cumming, Jong-Hoon Kim   +7 more
doaj   +1 more source

Revisiting the Radiosynthesis of [¹⁸F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer’s Disease

Molecules, 2020
[18F]FPEB is a positron emission tomography (PET) radiopharmaceutical used for imaging the abundance and distribution of mGluR5 in the central nervous system (CNS).
Cassis Varlow, Emily Murrell, Jason P. Holland, Alina Kassenbrock, Whitney Shannon, Steven H. Liang, Neil Vasdev, Nickeisha A. Stephenson   +7 more
doaj   +1 more source

Profiling the Structural Determinants of Aryl Benzamide Derivatives as Negative Allosteric Modulators of mGluR5 by In Silico Study

Molecules, 2020
Glutamate plays a crucial role in the treatment of depression by interacting with the metabotropic glutamate receptor subtype 5 (mGluR5), whose negative allosteric modulators (NAMs) are thus promising antidepressants.
Yujing Zhao, Jiabin Chen, Qilei Liu, Yan Li   +3 more
doaj   +1 more source

Targeting MOR-mGluR5 heteromers reduces bone cancer pain by activating MOR and inhibiting mGluR5 [PDF]

Neuropharmacology, 2019
Pain is among the most common symptoms in cancer and approximately 90% of patients experience end-stage cancer pain. The management of cancer pain is challenging due to the significant side effects associated with opioids, and novel therapeutic approaches are needed. MMG22 is a bivalent ligand containing MOR agonist and mGluR5 antagonist pharmacophores
Sarah S. Shueb, Samuel J. Erb, Eyup Akgün, Rebecca Speltz, Philip S. Portoghese, Donald A. Simone, Catherine Harding-Rose, Mary M. Lunzer   +7 more
openaire   +3 more sources

Activation of mGluR5 and NMDA Receptor Pathways in the Rostral Ventrolateral Medulla as a Central Mechanism for Methamphetamine-Induced Pressor Effect in Rats

Biomolecules, 2020
Acute hypertension produced by methamphetamine (MA) is well known, mainly by the enhancement of catecholamine release from sympathetic terminals. However, the central pressor mechanism of the blood-brain-barrier-penetrating molecule remains unclear.
Chih-Chia Lai, Chi Fang, Chung-Yi Kuo, Ya-Wen Wu, Hsun-Hsun Lin   +4 more
doaj   +1 more source