Results 21 to 30 of about 17,948 (248)
Frontiers in Cell and Developmental Biology, 2022 Metabotropic glutamate receptor subtype 5 (mGluR5) is a G-protein-coupled receptor found widely in the central nervous system. It has been involved in the development and progression of some neurodegenerative diseases, but its role in prion diseases is ...
Chao Hu +19 more
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Molecules, 2020 [18F]FPEB is a positron emission tomography (PET) radiopharmaceutical used for imaging the abundance and distribution of mGluR5 in the central nervous system (CNS).
Cassis Varlow +7 more
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Molecules, 2020 Glutamate plays a crucial role in the treatment of depression by interacting with the metabotropic glutamate receptor subtype 5 (mGluR5), whose negative allosteric modulators (NAMs) are thus promising antidepressants.
Yujing Zhao +3 more
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Unraveling Hierarchical Brain Dysfunction in Major Depressive Disorder: A Multimodal Imaging and Transcriptomic Approach. [PDF]
Hum Brain MappDysfunctional hierarchy in major depressive disorder (MDD) features decreased SDI in regions linked to high‐order cognitive functions, like the prefrontal, parietal, and orbitofrontal cortices. Conversely, areas related to low‐level sensory‐motor functions, the somatosensory cortex, showed increased SDI in MDD.
Xiayan C +8 more
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Targeting MOR-mGluR5 heteromers reduces bone cancer pain by activating MOR and inhibiting mGluR5 [PDF]
Neuropharmacology, 2019 Pain is among the most common symptoms in cancer and approximately 90% of patients experience end-stage cancer pain. The management of cancer pain is challenging due to the significant side effects associated with opioids, and novel therapeutic approaches are needed. MMG22 is a bivalent ligand containing MOR agonist and mGluR5 antagonist pharmacophores
Sarah S. Shueb +7 more
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Biomolecules, 2020 Acute hypertension produced by methamphetamine (MA) is well known, mainly by the enhancement of catecholamine release from sympathetic terminals. However, the central pressor mechanism of the blood-brain-barrier-penetrating molecule remains unclear.
Chih-Chia Lai +4 more
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mGluR5 ablation in cortical glutamatergic neurons increases novelty-induced locomotion. [PDF]
PLoS ONE, 2013 The group I metabotropic glutamate receptor 5 (mGluR5) has been implicated in the pathology of various neurological disorders including schizophrenia, ADHD, and autism.
Chris P Jew +7 more
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mGluR5 in amygdala modulates fear memory generalization
Frontiers in Behavioral Neuroscience, 2023 IntroductionFear memory generalization is regarded as the core characteristic of posttraumatic stress disorder (PTSD) development. However, the mechanism that contributes to the generalization of conditioned fear memory is still unclear. The generalization is generally considered to be a mismatch that occurs during memory consolidation.MethodsFoot ...
Shou-Min Xuan +11 more
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Metabotropic glutamate receptor 5 (mGluR5) regulates white adipocyte browning [PDF]
Jichu yixue yu linchuang, 2021 Objective To investigate whether mGluR5 could regulate white adipocytes browning. Methods Western blot was used to test the expression of mGluR5 in white and brown adipose tissue. Lipid droplets morphology was microscoped after BODIPY staining.
LUO Xie, ZENG Li, YUAN Lei
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In vivo imaging of mGluR5 changes during epileptogenesis using [11C]ABP688 PET in pilocarpine-induced epilepsy rat model. [PDF]
PLoS ONE, 2014 Metabotropic glutamate receptor 5 (mGluR5) that regulates glutamatergic neurotransmission contributes to pathophysiology of epilepsy. In this study, we monitored the changes of mGluR5 in vivo using [11C]ABP688 PET during the epileptogenesis in a ...
Hongyoon Choi +11 more
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