Results 21 to 30 of about 20,586 (243)

Conditional deletion of TRPC1 channel modulates synaptic plasticity, long term depression, and memory extinction in Fragile X syndrome mice [PDF]

iScience
Summary: Group I metabotropic glutamate receptors (mGluRs), particularly mGluR5, regulate synaptic plasticity via long-term depression (mGluR-LTD), a process implicated in declarative memory. We previously identified TRPC1, a highly expressed hippocampal
Farah Issa, Xavier Yerna, Thibaud Parpaite, Caren Jabbour, Olivier Schakman, Nicolas Tajeddine, Roberta Gualdani, Philippe Gailly   +7 more
doaj   +2 more sources

mGluR5 Is Substitutable for mGluR1 in Cerebellar Purkinje Cells for Motor Coordination, Developmental Synapse Elimination, and Motor Learning

Cells, 2022
Group I metabotropic glutamate receptors (mGluRs) include mGluR1 and mGluR5, which are coupled to the Gq family of heterotrimeric G-proteins and readily activated by their selective agonist 3,5-dihydroxyphenilglycine (DHPG).
Maria Harbers, Harumi Nakao, Takaki Watanabe, Kyoko Matsuyama, Shoichi Tohyama, Kazuki Nakao, Yasushi Kishimoto, Masanobu Kano, Atsu Aiba   +8 more
doaj   +1 more source

Encephalitis with mGluR5 antibodies [PDF]

Neurology, 2018
To report the clinical features of 11 patients with metabotropic glutamate receptor 5 (mGluR5) antibody-associated encephalitis, immunoglobulin G (IgG) subclass, and effects of the antibodies on neuronal mGluR5 clusters.Clinical information was retrospectively obtained from referring physicians.
Spatola, Marianna, Sabater, Lidia, Heaney, Nicholas, Tubridy, Niall, Munteis Olivas, Elvira, Rosenfeld, Myrna R, Graus, Francesc, Dalmau, Josep, Planagumà, Jesús, Martínez-Hernandez, Eugenia, Armangué, Thaís, Prüss, Harald, Iizuka, Takahiro, Caparó Oblitas, Ruben L, Antoine, Jean-Christophe, Li, Richard   +15 more
openaire   +4 more sources

Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity. [PDF]

PLoS ONE, 2010
Dementia with Lewy bodies (DLB) and Parkinson's Disease (PD) are neurodegenerative disorders of the aging population characterized by the abnormal accumulation of alpha-synuclein (alpha-syn).
Diana L Price, Edward Rockenstein, Kiren Ubhi, Van Phung, Natalie MacLean-Lewis, David Askay, Anna Cartier, Brian Spencer, Christina Patrick, Paula Desplats, Mark H Ellisman, Eliezer Masliah   +11 more
doaj   +1 more source

mGluR5 in amygdala modulates fear memory generalization

Frontiers in Behavioral Neuroscience, 2023
IntroductionFear memory generalization is regarded as the core characteristic of posttraumatic stress disorder (PTSD) development. However, the mechanism that contributes to the generalization of conditioned fear memory is still unclear. The generalization is generally considered to be a mismatch that occurs during memory consolidation.MethodsFoot ...
Shou-Min Xuan, Ya-Wen Su, Yi-Meng Liang, Zhen-Jie Gao, Chun-Yan Liu, Bu-Fang Fan, Yan-Wei Shi, Yan-Wei Shi, Xiao-Guang Wang, Xiao-Guang Wang, Hu Zhao, Hu Zhao   +11 more
openaire   +3 more sources

PET imaging of mGluR5 in Alzheimer’s disease [PDF]

Alzheimer's Research & Therapy, 2020
Abstract Background Metabotropic glutamate subtype 5 receptors (mGluR5) modulate synaptic transmission and may constitute an important therapeutic target in Alzheimer’s disease (AD) by mediating the synaptotoxic action of amyloid-β oligomers.
Adam P. Mecca, Julia W. McDonald, Hannah R. Michalak, Tyler A. Godek, Joanna E. Harris, Erika A. Pugh, Emily C. Kemp, Ming-Kai Chen, Arash Salardini, Nabeel B. Nabulsi, Keunpoong Lim, Yiyun Huang, Richard E. Carson, Stephen M. Strittmatter, Christopher H. van Dyck   +14 more
openaire   +3 more sources

Different Aberrant Changes of mGluR5 and Its Downstream Signaling Pathways in the Scrapie-Infected Cell Line and the Brains of Scrapie-Infected Experimental Rodents

Frontiers in Cell and Developmental Biology, 2022
Metabotropic glutamate receptor subtype 5 (mGluR5) is a G-protein-coupled receptor found widely in the central nervous system. It has been involved in the development and progression of some neurodegenerative diseases, but its role in prion diseases is ...
Chao Hu, Cao Chen, Cao Chen, Ying Xia, Jia Chen, Wei Yang, Lin Wang, Lin Wang, Dong-Dong Chen, Yue-Zhang Wu, Qin Fan, Xiao-Xi Jia, Kang Xiao, Qi Shi, Qi Shi, Zhi-Bao Chen, Xiao-Ping Dong, Xiao-Ping Dong, Xiao-Ping Dong, Xiao-Ping Dong   +19 more
doaj   +1 more source

Combined Treatment with Minocycline and an mGluR5 Antagonist Alters Resting EEG Spectral Power, but Not Sound-Evoked Responses, in a Mouse Model of Fragile X Syndrome. [PDF]

ASN Neuro
Kassir MH, Lovelace JW, Binder DK, Ethell IE, Razak KA.   +4 more
europepmc   +2 more sources

Targeting MOR-mGluR5 heteromers reduces bone cancer pain by activating MOR and inhibiting mGluR5 [PDF]

Neuropharmacology, 2019
Pain is among the most common symptoms in cancer and approximately 90% of patients experience end-stage cancer pain. The management of cancer pain is challenging due to the significant side effects associated with opioids, and novel therapeutic approaches are needed. MMG22 is a bivalent ligand containing MOR agonist and mGluR5 antagonist pharmacophores
Sarah S, Shueb, Samuel J, Erb, Mary M, Lunzer, Rebecca, Speltz, Catherine, Harding-Rose, Eyup, Akgün, Donald A, Simone, Philip S, Portoghese   +7 more
openaire   +2 more sources

In vivo glucose metabolism and glutamate levels in mGluR5 knockout mice: a multimodal neuroimaging study using [18F]FDG microPET and MRS

EJNMMI Research, 2020
Background Perturbed functional coupling between the metabotropic glutamate receptor-5 (mGluR5) and N-methyl-d-aspartate (NMDA) receptor-mediated excitatory glutamatergic neurotransmission may contribute to the pathophysiology of psychiatric disorders ...
Yo-Han Joo, Yun-Kwan Kim, In-Gyu Choi, Hyeon-Jin Kim, Young-Don Son, Hang-Keun Kim, Paul Cumming, Jong-Hoon Kim   +7 more
doaj   +1 more source