Results 31 to 40 of about 20,586 (243)
mGluR5 stimulates gliotransmission in the nucleus accumbens [PDF]
Proceedings of the National Academy of Sciences, 2007 Although metabotropic glutamate receptor 5 (mGluR5) is essential for cocaine self-administration and drug-seeking behavior, there is limited knowledge of the cellular actions of this receptor in the nucleus accumbens (NAc). Although mGluR5 has the potential to regulate neurons directly, recent studies have shown the importance of mGluR5 in
D'Ascenzo, Marcello +7 more
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Metabotropic glutamate receptor 5 (mGluR5) regulates white adipocyte browning [PDF]
Jichu yixue yu linchuang, 2021 Objective To investigate whether mGluR5 could regulate white adipocytes browning. Methods Western blot was used to test the expression of mGluR5 in white and brown adipose tissue. Lipid droplets morphology was microscoped after BODIPY staining.
LUO Xie, ZENG Li, YUAN Lei
doaj
Molecules, 2020 [18F]FPEB is a positron emission tomography (PET) radiopharmaceutical used for imaging the abundance and distribution of mGluR5 in the central nervous system (CNS).
Cassis Varlow +7 more
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Preso1, mGluR5 and the machinery of pain [PDF]
Nature Neuroscience, 2012 By bringing mGluR1/5 and proline-directed kinases together, the scaffold protein Preso1 stabilizes the interaction between mGluR1/5 and Homer. This mechanism may attenuate calcium influx into spinal neurons and reduce pain.
Jelena, Radulovic, Natalie C, Tronson
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In vivo imaging of mGluR5 changes during epileptogenesis using [11C]ABP688 PET in pilocarpine-induced epilepsy rat model. [PDF]
PLoS ONE, 2014 Metabotropic glutamate receptor 5 (mGluR5) that regulates glutamatergic neurotransmission contributes to pathophysiology of epilepsy. In this study, we monitored the changes of mGluR5 in vivo using [11C]ABP688 PET during the epileptogenesis in a ...
Hongyoon Choi +11 more
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Acute inhibition of mGluR5 disrupts behavioral flexibility [PDF]
Neurobiology of Learning and Memory, 2016 Conditioned cues can sometimes elicit maladaptive responses as seen in the post-traumatic stress disorder (PTSD). Lack of effective fear extinction, which involves a process of inhibitory learning, is hypothesized to associate with PTSD. In this study, we tested the effect of acute pharmacological inhibition of mGluR5 activity on the extinction of fear
Ferzin, Sethna, Hongbing, Wang
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mGluR5 knockout mice exhibit normal conditioned place-preference to cocaine [PDF]
, 2011 Metabotropic glutamate receptor 5 (mGluR5) null mutant (-/-) mice have been reported to totally lack the reinforcing or locomotor stimulating effects of cocaine.
Andrew L. Varnell +2 more
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Molecules, 2020 Glutamate plays a crucial role in the treatment of depression by interacting with the metabotropic glutamate receptor subtype 5 (mGluR5), whose negative allosteric modulators (NAMs) are thus promising antidepressants.
Yujing Zhao +3 more
doaj +1 more source
Chronic Stress, 2022 Background A robust literature supports the role of the metabotropic glutamate receptor type 5 (mGluR5) in cognitive functioning. mGluR5 is also implicated in the pathophysiology of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD),
Irina Esterlis +7 more
doaj +1 more source
Frontiers in Neurology, 2022 Abnormalities in the expression of metabotropic glutamate receptor type 5 (mGluR5) have been observed in the hippocampus of patients with drug-resistant mesial Temporal Lobe Epilepsy (mTLE).
Maria Zimmermann +14 more
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