Results 51 to 60 of about 17,948 (248)
Modulation of the GABAergic pathway for the treatment of fragile X syndrome. [PDF]
, 2014 Fragile X syndrome (FXS) is the most common genetic cause of intellectual disability and the most common single-gene cause of autism. It is caused by mutations on the fragile X mental retardation gene (FMR1) and lack of fragile X mental retardation ...
Hagerman, Randi J +2 more
core +1 more source
Nanoscopic spine localization of Norbin, an mGluR5 accessory protein [PDF]
BMC Neuroscience, 2014 Norbin is a neuron-specific, cytosolic protein that interacts with the metabotropic glutamate receptor 5 (mGluR5) and has a profound impact on mGluR5 signaling. Yet, little is known about its synaptic distribution.Here we have analyzed the spatial relationship between Norbin, postsynaptic density protein 95 (PSD-95), actin and mGluR5 in spines using ...
Maria Lindskog +5 more
openaire +3 more sources
Cells, 2023 Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons (MNs). Astrocytes display a toxic phenotype in ALS, which results in MN damage.
Carola Torazza +15 more
doaj +1 more source
Targeting mGlu5 metabotropic glutamate receptors in the treatment of cognitive dysfunction in a mouse model of phenylketonuria [PDF]
, 2018 We studied group-I metabotropic glutamate (mGlu) receptors in Pah(enu2) (ENU2) mice, which mimic the genetics and neurobiology of human phenylketonuria (PKU), a metabolic disorder characterized, if untreated, by autism, and intellectual disability (ID ...
Battaglia, Giuseppe +12 more
core +2 more sources
β-N-methylamino-L-alanine Enhances Neurotoxicity Through Multiple Mechanisms [PDF]
, 2007 The idea that the environmental toxin β-N-methylamino-l-alanine (BMAA) is involved in neurodegenerative diseases on Guam has risen and fallen over the years.
Lobner, Doug +3 more
core +2 more sources
Journal of Pain Research, 2020 Sisi Wang,* Junying Du,* Fangbing Shao, Wen Wang, Haiju Sun, Xiaomei Shao, Yi Liang, Boyi Liu, Jianqiao Fang, Junfan Fang Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key ...
Wang S +9 more
doaj
Brain Sciences, 2023 Background: Metabotropic glutamate receptors type 5 (mGluR5) play a central role in persistent forms of synaptic plasticity and memory formation. Antibodies to mGluR5 have been reported to be clinically associated with memory impairment.
Niels Hansen +6 more
doaj +1 more source
Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior [PDF]
, 2010 The central nucleus of the amygdala (CeA) has been identified as a site of nociceptive processing important for sensitization induced by peripheral injury. However, the cellular signaling components underlying this function remain unknown.
Carrasquillo, Yarimar +6 more
core +2 more sources
CHIMIA, 2012 Involvement of metabotropic glutamate receptor subtype 5 (mGluR5) in physiological and pathophysiological processes in the brain has been demonstrated, and hence mGluR5 has emerged as an important drug target. [11C]-ABP688 is clinically the most
Selena Milicevic Sephton +6 more
doaj +1 more source
The BOLD signal and neurovascular coupling in autism [PDF]
, 2013 BOLD (blood oxygen level dependent) fMRI (functional magnetic resonance imaging) is commonly used to study differences in neuronal activity between human populations.
Harris, JJ, Reynell, C
core +1 more source