Results 61 to 70 of about 17,143 (247)

Electroacupuncture Regulates Pain Transition by Inhibiting the mGluR5-PKCϵ Signaling Pathway in the Dorsal Root Ganglia

Journal of Pain Research, 2020
Sisi Wang,* Junying Du,* Fangbing Shao, Wen Wang, Haiju Sun, Xiaomei Shao, Yi Liang, Boyi Liu, Jianqiao Fang, Junfan Fang Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key ...
Wang S, Du J, Shao F, Wang W, Sun H, Shao X, Liang Y, Liu B, Fang J, Fang J   +9 more
doaj  

Development of [18F]-PSS223 as a PET Tracer for Imaging of Metabotropic Glutamate Receptor Subtype 5 (mGluR5)

CHIMIA, 2012
Involvement of metabotropic glutamate receptor subtype 5 (mGluR5) in physiological and pathophysiological processes in the brain has been demonstrated, and hence mGluR5 has emerged as an important drug target. [11C]-ABP688 is clinically the most
Selena Milicevic Sephton, Patrick Dennler, Dominique S. Leutwiler, Linjing Mu, Roger Schibli, Stefanie D. Krämer, Simon M. Ametamey   +6 more
doaj   +1 more source

Persisting Verbal Memory Encoding and Recall Deficiency after mGluR5 Autoantibody-Mediated Encephalitis

Brain Sciences, 2023
Background: Metabotropic glutamate receptors type 5 (mGluR5) play a central role in persistent forms of synaptic plasticity and memory formation. Antibodies to mGluR5 have been reported to be clinically associated with memory impairment.
Niels Hansen, Kristin Rentzsch, Sina Hirschel, Jens Wiltfang, Björn H. Schott, Berend Malchow, Claudia Bartels   +6 more
doaj   +1 more source

Genetic Downregulation of the Metabotropic Glutamate Receptor Type 5 Dampens the Reactive and Neurotoxic Phenotype of Adult ALS Astrocytes

Cells, 2023
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons (MNs). Astrocytes display a toxic phenotype in ALS, which results in MN damage.
Carola Torazza, Francesca Provenzano, Elena Gallia, Maria Cerminara, Matilde Balbi, Tiziana Bonifacino, Sara Tessitore, Silvia Ravera, Cesare Usai, Ilaria Musante, Aldamaria Puliti, Ludo Van Den Bosch, Paymaan Jafar-nejad, Frank Rigo, Marco Milanese, Giambattista Bonanno   +15 more
doaj   +1 more source

β-N-methylamino-L-alanine Enhances Neurotoxicity Through Multiple Mechanisms [PDF]

, 2007
The idea that the environmental toxin β-N-methylamino-l-alanine (BMAA) is involved in neurodegenerative diseases on Guam has risen and fallen over the years.
Lobner, Doug, Peoples, Robert W., Piana, Peachy Mae T., Salous, Abed K.   +3 more
core   +2 more sources

Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation

Acta Neuropathologica, 2015
Knockout of genes encoding metabotropic glutamate receptor 5 (mGluR5) or its endogenous regulators, such as Norbin, induce a schizophrenia-like phenotype in rodents, suggesting dysregulation of mGluR5 in schizophrenia. Human genetic and pharmacological animal studies support this hypothesis, but no studies have explored mGluR5 dysfunction at the ...
Jeremy S. Lum, Jeremy S. Lum, Kelly A. Newell, Kelly A. Newell, Xu-Feng Huang, Xu-Feng Huang, Francesca Fernandez-Enright, Samantha J. Fung, Samantha J. Fung, Martin Engel, Martin Engel, Jessica L. Andrews, Jessica L. Andrews, Natalie Matosin, Natalie Matosin, Cynthia Shannon Weickert, Cynthia Shannon Weickert   +16 more
openaire   +5 more sources

mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington’s disease

Molecular Brain, 2020
Repressor element 1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) is a transcription repressor and its expression is regulated by the Wnt pathway through β-catenin.
Jéssica M. de Souza, Khaled S. Abd-Elrahman, Fabiola M. Ribeiro, Stephen S. G. Ferguson   +3 more
doaj   +1 more source

Orchestrated activation of mGluR5 and CB1 promotes neuroprotection

Molecular Brain, 2016
The metabotropic glutamate receptor 5 (mGluR5) and the cannabinoid receptor 1 (CB1) exhibit a functional interaction, as CB1 regulates pre-synaptic glutamate release and mGluR5 activation increases endocannabinoid synthesis at the post-synaptic site. Since both mGluR5 and CB1 promote neuroprotection, we delineated experiments to investigate a possible ...
Batista, Edleusa M L, Doria, Juliana G, Ferreira-Vieira, Talita H, Alves-Silva, Juliana, Ferguson, Stephen S G, Moreira, Fabricio A, Ribeiro, Fabiola M   +6 more
openaire   +4 more sources

Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer’s disease mouse models

Molecular Brain, 2018
Alzheimer’s disease (AD) is characterized by neurotoxicity mediated by the accumulation of beta amyloid (Aβ) oligomers, causing neuronal loss and progressive cognitive decline.
Khaled S. Abd-Elrahman, Alison Hamilton, Maryam Vasefi, Stephen S. G. Ferguson   +3 more
doaj   +1 more source

mGluR5 is transiently confined in perisynaptic nanodomains to shape synaptic function

Nature Communications, 2023
The subsynaptic organization of group I mGluRs modulates their activation and downstream signaling, essential for synaptic transmission and plasticity.
Nicky Scheefhals, Manon Westra, Harold D. MacGillavry   +2 more
doaj   +1 more source