Results 61 to 70 of about 17,948 (248)
Acta Neuropathologica, 2015 Knockout of genes encoding metabotropic glutamate receptor 5 (mGluR5) or its endogenous regulators, such as Norbin, induce a schizophrenia-like phenotype in rodents, suggesting dysregulation of mGluR5 in schizophrenia. Human genetic and pharmacological animal studies support this hypothesis, but no studies have explored mGluR5 dysfunction at the ...
Jeremy S. Lum +16 more
openaire +5 more sources
Orchestrated activation of mGluR5 and CB1 promotes neuroprotection
Molecular Brain, 2016 The metabotropic glutamate receptor 5 (mGluR5) and the cannabinoid receptor 1 (CB1) exhibit a functional interaction, as CB1 regulates pre-synaptic glutamate release and mGluR5 activation increases endocannabinoid synthesis at the post-synaptic site. Since both mGluR5 and CB1 promote neuroprotection, we delineated experiments to investigate a possible ...
Batista, Edleusa M L +6 more
openaire +4 more sources
Molecular Brain, 2018 Alzheimer’s disease (AD) is characterized by neurotoxicity mediated by the accumulation of beta amyloid (Aβ) oligomers, causing neuronal loss and progressive cognitive decline.
Khaled S. Abd-Elrahman +3 more
doaj +1 more source
The prion protein regulates glutamate-mediated Ca2+ entry and mitochondrial Ca2+ accumulation in neurons [PDF]
, 2017 The cellular prion protein (PrPC) whose conformational misfolding leads to the production of deadly prions, has a still-unclarified cellular function despite decades of intensive research.
Bertoli, Alessandro +8 more
core +1 more source
mGluR5 is transiently confined in perisynaptic nanodomains to shape synaptic function
Nature Communications, 2023 The subsynaptic organization of group I mGluRs modulates their activation and downstream signaling, essential for synaptic transmission and plasticity.
Nicky Scheefhals +2 more
doaj +1 more source
International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 23-30, April 2025.Abstract Autoimmune encephalitis is a group of disorders characterized by symptoms of dysfunction of the limbic and extra‐limbic systems that occur in association with antibodies against intracellular antigens, synapses, or proteins located on the surface of nerve cells. Anti‐NMDA (N‐methyl‐D‐aspartate) receptor encephalitis was first described in 2007
Pham Ba Nha +6 more
wiley +1 more source
Frontiers in Psychiatry, 2019 Although several studies have found that metabotropic glutamate 5 receptor (mGluR5) may play an important role in autism spectrum disorders (ASD), the mechanisms remain unclear.
Guohong Cai +12 more
doaj +1 more source
Collaborative development of the Arrowsmith two node search interface designed for laboratory investigators. [PDF]
, 2006 Arrowsmith is a unique computer-assisted strategy designed to assist investigators in detecting biologically-relevant connections between two disparate sets of articles in Medline.
Bischoff-Grethe, Amanda +11 more
core +3 more sources
Movement Disorders, EarlyView.Abstract Background Fatigue in Parkinson's disease (PD) is a prevalent and debilitating non‐motor symptom. Despite its significant impact on quality of life, the underlying neurochemical and network‐based mechanisms remain poorly understood. Objectives This observational study applied a multimodal imaging approach to explore potential links between the
Ilaria Antonella Di Vico +14 more
wiley +1 more source
Nitrative Stress in Cerebral Endothelium is Mediated by mGluR5 in Hyperhomocysteinemia [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2011 Hyperhomocysteinemia (HHcy) disrupts nitric oxide (NO) signaling and increases nitrative stress in cerebral microvascular endothelial cells (CMVECs). This is mediated, in part, by protein nitrotyrosinylation (3-nitrotyrosine; 3-NT) though the mechanisms by which extracellular homocysteine (Hcy) generates intracellular 3-NT are unknown.
Nuran Ercal +9 more
openaire +3 more sources