Results 71 to 80 of about 17,143 (247)

Collaborative development of the Arrowsmith two node search interface designed for laboratory investigators. [PDF]

, 2006
Arrowsmith is a unique computer-assisted strategy designed to assist investigators in detecting biologically-relevant connections between two disparate sets of articles in Medline.
Bischoff-Grethe, Amanda, Burhans, Lauren B, Gabriel, Michael, Homayouni, Ramin, Kashef, Alireza, Martone, Maryann E, Perkins, Guy A, Price, Diana L, Smalheiser, Neil R, Talk, Andrew C, Torvik, Vetle I, West, Ruth   +11 more
core   +3 more sources

Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and connectivity [PDF]

, 2023
Stroke results in local neural disconnection and brain-wide neuronal network dysfunction leading to neurological deficits. Beyond the hyper-acute phase of ischaemic stroke, there is no clinically-approved pharmacological treatment that alleviates ...
Bauer, Adam Q, Di Menna, Luisa, Englund, Elisabet, Hakon, Jakob, Kim, Byungchan, Mastroiacovo, Federica, Moyanova, Slavianka, Nicoletti, Ferdinando, Olsson, Roger, Quattromani, Miriana J, Ruscher, Karsten, Sjölund, Carin, Talhada, Daniela, Wieloch, Tadeusz   +13 more
core   +2 more sources

The BOLD signal and neurovascular coupling in autism [PDF]

, 2013
BOLD (blood oxygen level dependent) fMRI (functional magnetic resonance imaging) is commonly used to study differences in neuronal activity between human populations.
Harris, JJ, Reynell, C
core   +1 more source

Disentangling the Switching Behavior in Functional Connectivity Dynamics in Autism Spectrum Disorder: Insights from Developmental Cohort Analysis and Molecular‐Cellular Associations

Advanced Science, EarlyView.
A region‐wise functional connectivity dynamics (FCD) switching index (RFSI) identifies abnormal drivers in ASD across development, linked to salience/ventral attention, default mode, and frontoparietal networks. RFSI changes correlate with transcriptomic and neurotransmitter profiles, and supported by gene‐edited ASD monkeys.
Wei Li, Xia Qiu, Jin Chen, Kexuan Chen, Meiling Chen, Yinyan Wang, Wenjie Sun, Jing Su, Yongchang Chen, Xiaobao Liu, Congying Chu, Jiaojian Wang   +11 more
wiley   +1 more source

Blockade of mGluR5 in astrocytes derived from human iPSCs modulates astrocytic function and increases phagocytosis

Frontiers in Immunology, 2023
TNF-α is essential for induction and maintenance of inflammatory responses and its dysregulation is associated with susceptibility to various pathogens that infect the central nervous system.
Izabella B. Q. de Lima, Pablo L. Cardozo, Julia S. Fahel, Juliana P. S. Lacerda, Aline S. Miranda, Antônio L. Teixeira, Fabiola M. Ribeiro   +6 more
doaj   +1 more source

Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer’s disease: A [18F]PSS232 PET/MRI study

Alzheimer’s Research & Therapy
Background Metabotropic glutamate receptor 5 (mGluR5) is involved in regulating integrative brain function and synaptic transmission. Aberrant mGluR5 signaling and relevant synaptic failure play a key role in the initial pathophysiological mechanism of ...
Jie Wang, Yingfang He, Xing Chen, Lin Huang, Junpeng Li, Zhiwen You, Qi Huang, Shuhua Ren, Kun He, Roger Schibli, Linjing Mu, Yihui Guan, Qihao Guo, Jun Zhao, Fang Xie   +14 more
doaj   +1 more source

Spinal Teratoma with Recurrent Epileptic Episodes in Adults: A Case Report

Case Reports in Neurology
Introduction: Spinal teratomas are rare, accounting for nearly 0.2–0.5% of all spinal tumors and 2% of all teratomas. Teratomas at the conus medullaris location do not inherently lead to epilepsy.
Jinlong Wang, Bo Cao
doaj   +1 more source

G protein-coupled receptor signalling in astrocytes in health and disease: A focus on metabotropic glutamate receptors [PDF]

, 2012
Work published over the past 10–15 years has caused the neuroscience community to engage in a process of constant re-evaluation of the roles of glial cells in the mammalian central nervous system.
Bradley, Sophie J., Challiss, R.A. John
core   +1 more source

Temporal Profiling of Male Cortical Astrocyte Transcription Predicts Molecular Shifts From Early Development to Aging

Glia, EarlyView.
Comprehensive analysis of cortical astrocyte gene expression across the lifespan. Profiling dynamic changes of key astrocyte genes reveals functional shifts. Astrocytes contribute to gene‐length‐dependent transcription decline in the aging brain. ABSTRACT Astrocytes are the most abundant glial cell type in the central nervous system (CNS).
Xiaoran Wei, Jiangtao Li, Michelle L. Olsen   +2 more
wiley   +1 more source

Multi‐Omic Analysis Reveals Astrocytic Annexin‐A2 as Critical for Network‐Level Circadian Timekeeping in the Suprachiasmatic Nucleus

Glia, EarlyView.
ABSTRACT The mammalian suprachiasmatic nucleus (SCN) orchestrates daily (circadian) rhythms of physiology and behavior by broadcasting timing cues generated autonomously by its mutually reinforcing network of ~10,000 neurons and ~3000 astrocytes. Although astrocytic control of extracellular glutamate and GABA has been implicated in driving circadian ...
Andrew P. Patton, Toke P. Krogager, Elizabeth S. Maywood, Nicola J. Smyllie, Emma L. Morris, Mark Skehel, Michael H. Hastings   +6 more
wiley   +1 more source