Results 71 to 80 of about 20,586 (243)

Orchestrated activation of mGluR5 and CB1 promotes neuroprotection

Molecular Brain, 2016
The metabotropic glutamate receptor 5 (mGluR5) and the cannabinoid receptor 1 (CB1) exhibit a functional interaction, as CB1 regulates pre-synaptic glutamate release and mGluR5 activation increases endocannabinoid synthesis at the post-synaptic site. Since both mGluR5 and CB1 promote neuroprotection, we delineated experiments to investigate a possible ...
Batista, Edleusa M L, Doria, Juliana G, Ferreira-Vieira, Talita H, Alves-Silva, Juliana, Ferguson, Stephen S G, Moreira, Fabricio A, Ribeiro, Fabiola M   +6 more
openaire   +3 more sources

mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington’s disease

Molecular Brain, 2020
Repressor element 1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) is a transcription repressor and its expression is regulated by the Wnt pathway through β-catenin.
Jéssica M. de Souza, Khaled S. Abd-Elrahman, Fabiola M. Ribeiro, Stephen S. G. Ferguson   +3 more
doaj   +1 more source

mGluR5 is transiently confined in perisynaptic nanodomains to shape synaptic function

Nature Communications, 2023
The subsynaptic organization of group I mGluRs modulates their activation and downstream signaling, essential for synaptic transmission and plasticity.
Nicky Scheefhals, Manon Westra, Harold D. MacGillavry   +2 more
doaj   +1 more source

mGluR5 mediates post-radiotherapy fatigue development in cancer patients [PDF]

Translational Psychiatry, 2018
AbstractCancer-related fatigue (CRF) is a common burden in cancer patients and little is known about its underlying mechanism. The primary aim of this study was to identify gene signatures predictive of post-radiotherapy fatigue in prostate cancer patients.
Li Rebekah Feng, Juan Luis Fernández-Martínez, Kristien J.M. Zaal, Enrique J deAndrés-Galiana, Brian S. Wolff, Leorey N. Saligan   +5 more
openaire   +3 more sources

Brain mGluR5 in Shank3B−/− Mice Studied With in vivo [18F]FPEB PET Imaging and ex vivo Immunoblotting

Frontiers in Psychiatry, 2019
Although several studies have found that metabotropic glutamate 5 receptor (mGluR5) may play an important role in autism spectrum disorders (ASD), the mechanisms remain unclear.
Guohong Cai, Mengmeng Wang, Shuailiang Wang, Yi Liu, Yan Zhao, Yuanyuan Zhu, Suo Zhao, Ming Zhang, Baolin Guo, Han Yao, Wenting Wang, Jing Wang, Shengxi Wu   +12 more
doaj   +1 more source

Effect of age on brain metabotropic glutamate receptor subtype 5 measured with [18F]FPEB PET

NeuroImage, 2021
Objective: Metabotropic glutamate receptor subtype 5 (mGluR5) is integral to the brain glutamatergic system and cognitive function. This study investigated whether aging is associated with decreased brain mGluR5 availability.
Adam P. Mecca, Kelly Rogers, Zachary Jacobs, Julia W. McDonald, Hannah R. Michalak, Nicole DellaGioia, Wenzhen Zhao, Ansel T Hillmer, Nabeel Nabulsi, Keunpoong Lim, Jim Ropchan, Yiyun Huang, David Matuskey, Irina Esterlis, Richard E. Carson, Christopher H. van Dyck   +15 more
doaj   +1 more source

Glutamatergic Plasticity in Medial Prefrontal Cortex and Ventral Tegmental Area Following Extended-Access Cocaine Self-Administration [PDF]

, 2011
Glutamate signaling in prefrontal cortex and ventral tegmental area plays an important role in the molecular and behavioral plasticity associated with addiction to drugs of abuse.
Ghasemzadeh, Behnam, Giles, Chad, Mantsch, John R., Purgianto, Anthony, Seubert, Chad, Vasudevan, Preethi   +5 more
core   +2 more sources

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer’s disease: A [18F]PSS232 PET/MRI study

Alzheimer’s Research & Therapy
Background Metabotropic glutamate receptor 5 (mGluR5) is involved in regulating integrative brain function and synaptic transmission. Aberrant mGluR5 signaling and relevant synaptic failure play a key role in the initial pathophysiological mechanism of ...
Jie Wang, Yingfang He, Xing Chen, Lin Huang, Junpeng Li, Zhiwen You, Qi Huang, Shuhua Ren, Kun He, Roger Schibli, Linjing Mu, Yihui Guan, Qihao Guo, Jun Zhao, Fang Xie   +14 more
doaj   +1 more source