Results 81 to 90 of about 17,948 (248)
Spotlight on Alzheimer's disease and related dementias research in East Asia
Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.Abstract With a burgeoning dementia burden driven by unique demographic, genetic, and socioeconomic factors of East Asia, the region has made significant investments in understanding disease mechanisms, developing biomarkers, and exploring therapeutic approaches.
Weidong Le +3 more
wiley +1 more source
In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation [PDF]
Proceedings of the National Academy of Sciences, 2019 Significance Posttraumatic stress disorder (PTSD) is an important risk factor for suicidal ideation, attempts, and death by suicide. Understanding of the biology underlying suicidality in PTSD is limited. In this study, we used positron emission tomography to evaluate the metabotropic glutamate receptor type 5 (mGluR5) as a potential ...
Gustavo A. Angarita +12 more
openaire +3 more sources
Improved retinal function in RCS rats after suppressing the over-activation of mGluR5
Scientific Reports, 2017 Müller cells maintain retinal synaptic homeostasis by taking up glutamate from the synaptic cleft and transporting glutamine back to the neurons. To study the interaction between Müller cells and photoreceptors, we injected either DL-α-aminoadipate or L ...
Jiaman Dai +4 more
doaj +1 more source
Elevated glycogen synthase kinase 3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential [PDF]
, 2007 Significant advances have been made in understanding the underlying defects of and developing potential treatments for Fragile X Syndrome (FXS), the most common heritable mental retardation.
Bauchwitz, Dr. Robert P.
core
Central amygdala metabotropic glutamate receptor 5 in the modulation of visceral pain [PDF]
, 2012 Painful bladder syndrome is a debilitating condition that affects 3–6% of women in the United States. Multiple lines of evidence suggest that changes in central nervous system processing are key to the development of chronic bladder pain conditions, but ...
Bruchas, Michael R +6 more
core +2 more sources
Glia, Volume 73, Issue 7, Page 1349-1364, July 2025.Main Points Comprehensive analysis of cortical astrocyte gene expression across the lifespan. Profiling dynamic changes of key astrocyte genes reveals functional shifts. Astrocytes contribute to gene‐length‐dependent transcription decline in the aging brain.
Xiaoran Wei +2 more
wiley +1 more source
Insulin-like Growth Factor 1 and Transforming Growth Factor-β Stimulate Cystine/Glutamate Exchange Activity in Dental Pulp Cells [PDF]
, 2011 Introduction The growth factors insulin-like growth factor (IGF-1) and transforming growth factor-β (TGF-β) are protective to dental pulp cells in culture against the toxicity of the composite materials Durafill VS and Flow Line (Henry Schein Inc, New ...
Alyssa Furey +39 more
core +2 more sources
Glia, Volume 73, Issue 7, Page 1483-1501, July 2025.Main Points Multi‐omics reveal Annexin‐A2 (A2) and S100a10 (A10) as SCN astrocyte enriched proteins. Disrupting A2‐A10 complex elevates astrocyte Ca2+ and compromises SCN timekeeping. Astrocytic A2‐A10 is a critical control point for SCN network rhythms.
Andrew P. Patton +6 more
wiley +1 more source
Mglur5: a Potential Target for the Treatment of Huntington's Disease [PDF]
Future Neurology, 2014 ISSN 1479-6708 Future Neurology (2014) 9(3), 289–293 Huntington’s disease Huntington’s disease (HD) is a progressive neurodegenerative disorder with an age of onset between 35 and 50 years. At first, HD patients experience chorea and psychiatric alterations, associated with intellectual decline and inevitable death within 15–20 years [1,2].
Stephen S. G. Ferguson +2 more
openaire +1 more source
PolyMorphine provides extended analgesic-like effects in mice with spared nerve injury. [PDF]
, 2017 Morphine is a well-characterized and effective analgesic commonly used to provide pain relief to patients suffering from both acute and chronic pain conditions.
Chen, Renxun +5 more
core +1 more source