Results 81 to 90 of about 17,143 (247)
Nitrative Stress in Cerebral Endothelium is Mediated by mGluR5 in Hyperhomocysteinemia [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2011 Hyperhomocysteinemia (HHcy) disrupts nitric oxide (NO) signaling and increases nitrative stress in cerebral microvascular endothelial cells (CMVECs). This is mediated, in part, by protein nitrotyrosinylation (3-nitrotyrosine; 3-NT) though the mechanisms by which extracellular homocysteine (Hcy) generates intracellular 3-NT are unknown.
Nuran Ercal +9 more
openaire +3 more sources
Movement Disorders, EarlyView.Abstract Background Fatigue in Parkinson's disease (PD) is a prevalent and debilitating non‐motor symptom. Despite its significant impact on quality of life, the underlying neurochemical and network‐based mechanisms remain poorly understood. Objectives This observational study applied a multimodal imaging approach to explore potential links between the
Ilaria Antonella Di Vico +14 more
wiley +1 more source
Frontiers in Psychiatry, 2019 Although several studies have found that metabotropic glutamate 5 receptor (mGluR5) may play an important role in autism spectrum disorders (ASD), the mechanisms remain unclear.
Guohong Cai +12 more
doaj +1 more source
Elevated glycogen synthase kinase 3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential [PDF]
, 2007 Significant advances have been made in understanding the underlying defects of and developing potential treatments for Fragile X Syndrome (FXS), the most common heritable mental retardation.
Bauchwitz, Dr. Robert P.
core
The prion protein regulates glutamate-mediated Ca2+ entry and mitochondrial Ca2+ accumulation in neurons [PDF]
, 2017 The cellular prion protein (PrPC) whose conformational misfolding leads to the production of deadly prions, has a still-unclarified cellular function despite decades of intensive research.
Bertoli, Alessandro +8 more
core +1 more source
In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation [PDF]
Proceedings of the National Academy of Sciences, 2019 Significance Posttraumatic stress disorder (PTSD) is an important risk factor for suicidal ideation, attempts, and death by suicide. Understanding of the biology underlying suicidality in PTSD is limited. In this study, we used positron emission tomography to evaluate the metabotropic glutamate receptor type 5 (mGluR5) as a potential ...
Gustavo A. Angarita +12 more
openaire +3 more sources
Rethinking metabotropic glutamate receptor 5 pathological findings in psychiatric disorders: implications for the future of novel therapeutics [PDF]
, 2014 Background Pharmacological modulation of metabotropic glutamate receptor 5 (mGluR5) is of marked interest as a novel therapeutic mechanism to treat schizophrenia and major depression.
Matosin, Natalie, Newell, Kelly A
core +2 more sources
Epilepsia, EarlyView.Abstract Objective This study was undertaken to describe a case series of Brazilian new onset refractory status epilepticus (NORSE) patients and evaluate the sensitivity and specificity of a clinical score to predict cryptogenic etiology (c‐NORSE score) after autoimmune encephalitis (AE) testing.
João Henrique Fregadolli Ferreira +42 more
wiley +1 more source
Mglur5: a Potential Target for the Treatment of Huntington's Disease [PDF]
Future Neurology, 2014 ISSN 1479-6708 Future Neurology (2014) 9(3), 289–293 Huntington’s disease Huntington’s disease (HD) is a progressive neurodegenerative disorder with an age of onset between 35 and 50 years. At first, HD patients experience chorea and psychiatric alterations, associated with intellectual decline and inevitable death within 15–20 years [1,2].
Stephen S. G. Ferguson +2 more
openaire +1 more source
Frontiers in Aging Neuroscience, 2018 Background: Modulation of Metabotropic glutamate receptor 5 (mGluR5) may be a novel therapeutic approach to manage Parkinson's disease (PD) Patients with L-dopa-induced dyskinesia (LID).Objectives: The objective of this meta-analysis was to evaluate the ...
Wen-Wen Wang +6 more
doaj +1 more source