Engineering Bacteria as Living Therapeutics in Cancer Therapy
Advanced Science, EarlyView.Through synthetic biology approaches, natural bacteria can be genetically programmed into multifunctional living therapeutics. These engineered bacteria are capable of secreting anti‐tumor factors, displaying tumor‐associated antigens on their surface, or undergoing programmed self‐lysis to release therapeutic cargo.
Jiangfeng Chen +6 more
wiley +1 more source
Targeting HDAC and PARP Enhances STING‐Dependent Antitumor Immunity in STING‐Deficient Tumor
Advanced Science, EarlyView.Dual HDAC and PARP inhibition restores STING signaling, enhances interferon response, and boosts antitumor immunity in STING‐deficient tumors. . Abstract The stimulator of interferon genes (STING)‐mediated innate immune pathway plays an important role in tumor immunosurveillance.
Chengzhou Mao +10 more
wiley +1 more source
Marek's Disease Resistance of B (MHC) Heterozygotes in a Cross of Purebred Leghorn Lines
, 1982 W. Elwood Briles +3 more
openalex +1 more source
Multiscale Cell–Cell Interactive Spatial Transcriptomics Analysis
Advanced Science, EarlyView.In this study, we present the MultiScale Cell‐Cell Interactive Spatial Transcriptomics Analysis method, which unites the strengths of spatially resolved deep learning techniques with a topological representation of multi‐scale cell‐cell similarity relations.
Sean Cottrell, Guo‐Wei Wei
wiley +1 more source
LYMPHOCYTE SUBPOPULATIONS AND MEMORY OF MHC ANTIGENS
, 1987 Jeffrey Herbert, Bruce Roser
openalex +1 more source
The human MHC-restricted cellular response to herpes simplex virus type 1 is mediated by CD4+, CD8- T cells and is restricted to the DR region of the MHC complex. [PDF]
, 1988 D. Scott Schmid
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Therapy‐Induced ECM Remodeling Creates a Transient Immune Barrier in Residual Melanoma
Advanced Science, EarlyView.BRAF/MEK inhibition promotes extracellular matrix (ECM) accumulation and remodeling during therapy‐tolerant residual disease, limiting CD8⁺ T cell access to tumor cells. Targeting ECM accumulation restores CD8⁺ T cell infiltration, enhances their intratumoral distribution, and delays therapeutic resistance.
Chia‐Hsin Hsu +6 more
wiley +1 more source
Prolonged survival of actively enhanced rat renal allografts despite accelerated cellular infiltration and rapid induction of both class I and class II MHC antigens. [PDF]
, 1987 H E Armstrong +4 more
openalex +1 more source
Advanced Science, EarlyView.Early coral skeletons grow through formation of two co‐joined zones, rapid accretion deposits and thickening deposits. Advanced imaging and simulations reveal that ocean acidification reshapes these zones, shifting the coral portfolio of mineral phases which alters skeletal resistance to mechanical stress.
Federica Scucchia +4 more
wiley +1 more source