Results 61 to 70 of about 472,378 (232)

The E5 protein of BPV-4 interacts with the heavy chain of MHC class I and irreversibly retains the MHC complex in the Golgi apparatus [PDF]

, 2006
BPV-4 E5 inhibits transcription of the bovine MHC class I heavy chain (HC) gene, increases degradation of HC and downregulates surface expression of MHC class I by retaining the complex in the Golgi apparatus (GA).
Araibi, E.H., Ashrafi, G.H., Campo, M.S., Dornan, E.S., Ellis, S.A., Marchetti, B.   +5 more
core   +1 more source

House sparrows do not exhibit a preference for the scent of potential partners with different MHC-I diversity and genetic distances.

PLoS ONE, 2022
MHC genes play a fundamental role in immune recognition of pathogens and parasites. Therefore, females may increase offspring heterozygosity and genetic diversity by selecting males with genetically compatible or heterozygous MHC.
Luisa Amo, Guillermo Amo de Paz, Johanna Kabbert, Annie Machordom   +3 more
doaj   +1 more source

Common Genetic Variant Association with Altered HLA Expression, Synergy with Pyrethroid Exposure, and Risk for Parkinson's Disease: An Observational and Case-Control Study. [PDF]

, 2015
Background/objectivesThe common non-coding single nucleotide polymorphism (SNP) rs3129882 in HLA-DRA is associated with risk for idiopathic Parkinson's disease (PD).
Boss, JM, Bronstein, J, Chang, J, Chung, J, Cook, DA, Factor, SA, Kannarkat, GT, Lee, J-K, Paul, KC, Ritz, B, Sandy, E, Tansey, MG   +11 more
core   +2 more sources

772 MHC-I skewing in mutant calreticulin-positive myeloproliferative neoplasms is countered by heteroclitic peptide cancer vaccination [PDF]

, 2021
Mathieu Gigoux, Roberta Zappasodi, Joseph Park, Cansu Cimen Bozkus, Levi Mangarin, David Redmond, Svena Verma, Sara Schad, Mariam M. George, Divya Venkatesh, Arnab Ghosh, Zaki Molvi, Baransel Kamaz, Anna E. Marneth, William S. Duke, Matthew Leventhal, Max Jan, Vincent T. Ho, Gabriela Hobbs, Trine Alma Knudsen, Vibe Skov, Lasse Kjær, Thomas Stauffer Larsen, Dennis Lund Hansen, R. Coleman Lindsley, Hans Carl Hasselbalch, Jacob Handlos Grauslund, Mads Hald Andersen, Morten Orebo Holmström, Timothy A. Chan, Raajit K. Rampal, Omar Abdel‐Wahab, Nina Bhardwaj, Ann Mullally, Jedd D. Wolchok, Taha Merghoub   +35 more
openalex   +1 more source

LSO-054 Genetic fine mapping of independent variants in MHC region associated with predisposition and clinical feature of systemic lupus erythematosus in Han Chinese population [PDF]

, 2023
Ke Xue, Yong Cui
openalex   +1 more source

A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometry

Nature Communications, 2022
MHC restriction depicts CD4+ T cell activation by MHC-II and CD8A+ by MHC-I, but rare T cells with mismatched MHC restriction have been reported. Here the authors use crystallography to describe features of such a mismatched TCR-MHC interaction and ...
Nishant K. Singh, Jesus A. Alonso, Jason R. Devlin, Grant L. J. Keller, George I. Gray, Adarsh K. Chiranjivi, Sara G. Foote, Lauren M. Landau, Alyssa G. Arbuiso, Laura I. Weiss, Aaron M. Rosenberg, Lance M. Hellman, Michael I. Nishimura, Brian M. Baker   +13 more
doaj   +1 more source

Associations between mental health competence and indicators of physical health and cognitive development in eleven year olds: findings from the UK Millennium Cohort Study

BMC Public Health, 2019
Background Positive mental health may support healthy development in childhood, although few studies have investigated this at a population level. We aimed to construct a measure of mental health competence (MHC), a skills-based assessment of positive ...
Steven Hope, Emeline Rougeaux, Jessica Deighton, Catherine Law, Anna Pearce   +4 more
doaj   +1 more source

Testing the theory of immune selection in cancers that break the rules of transplantation [PDF]

, 2009
Modification of cancer cells likely to reduce their immunogenicity, including loss or down-regulation of MHC molecules, is now well documented and has become the main support for the concept of immune surveillance.
A Garcia-Lora, A Scheffold, AF Setiadi, AM Pearse, Ariberto Fassati, B Comin-Anduix, B Kavanagh, B Muller-Hilke, C Murgia, CA Rebbeck, CC Chang, CL Yauk, CM Gonzalez, CM Koebel, CY Lin, D Cohen, D Cohen, D Cohen, D Cohen, E Ambrosino, E Klein, E Mozos, ED Carosella, ED Carosella, EK Geissler, FR Depontieu, G Willimsky, GD Snell, GP Dunn, GP Dunn, GP Dunn, H Ikeda, H McCallum, H Wajant, HV Siddle, HV Siddle, I Kryczek, J Galon, J Hori, J Perez, J Zhou, K Kretschmer, K Masuda, K Milne, KJ Malmberg, KL Wright, L Tian, L Vago, L Yip, M Bleakley, M Campoli, M Gerloni, M Mammolenti, M Mehling, M Novinski, M Pierobon, M Shackleton, M Thornley, MA Cheever, MN Scherer, N Mitchison, N Schwinn, N. Avrion Mitchison, NA Mitchison, NM Moutsopoulos, P Jimenez, PC Chou, R Mendez, R Mendez, R Uppaluri, S Lob, S Verheyden, SM Kang, SR Choudhury, T Akagi, T Cabrera, T Isoda, T Marchal, T Rodriguez, TJ Yang, TJ Yang, W Reith, YC Chang, YW Hsiao, YW Hsiao   +84 more
core   +2 more sources

Insulin B peptide-MHC class II-specific chimeric antigen receptor-Tregs prevent autoimmune diabetes in mice [PDF]

, 2023
Justin A. Spanier, Vivian Fung, Christine M. Wardell, Mohannad Alkhatib, Yixin Chen, Linnea A. Swanson, Alexander J. Dwyer, Matthew E. Weno, Nubia Silva, Jason S. Mitchell, Paul C. Orban, Majid Mojibian, C. Bruce Verchere, Brian T. Fife, Megan K. Levings   +14 more
openalex   +1 more source

Expression of MHC II genes

, 2005
Innate and adaptive immunity are connected via antigen processing and presentation (APP), which results in the presentation of antigenic peptides to T cells in the complex with the major histocompatibility (MHC) determinants.
Drozina, G., Jabrane-Ferrat, N., Kohoutek, J., Peterlin, B. M.   +3 more
core   +2 more sources