Results 71 to 80 of about 551,654 (347)

Structural analysis of the adenovirus type 2 E3/19K protein using mutagenesis and a panel of conformation-sensitive monoclonal antibodies [PDF]

, 2008
The E3/19K protein of human adenovirus type 2 (Ad2) was the first viral protein shown to interfere with antigen presentation. This 25 kDa transmembrane glycoprotein binds to major histocompatibility complex (MHC) class I molecules in the endoplasmic ...
Ahmed, Altschul, Andersson, Beatrice Menz, Beier, Bennett, Bruder, Bryson, Burgert, Burgert, Burgert, Burgert, Burgert, Cole, Cox, Deryckere, Edgar, Elsing, Feuerbach, Flomenberg, Flomenberg, Fox, Gabathuler, Gewurz, Ginsberg, Hans-Gerhard Burgert, Hermiston, Hilgendorf, Jackson, Jackson, Jefferies, Katja Koebernick, Kornfeld, Krogh, Kurowski, Köhler, Körner, Lichtenstein, Liu, Liu, Lodoen, Mans, Martina Sester, McNees, McSharry, Nilsson, Persson, Pääbo, Pääbo, Pääbo, Ralf Schmid, Rawle, Rost, Rost, Rost, Sester, Sester, Tanaka, The_UniProt_Consortium, von Herrath, Windheim, Wold, Wold   +62 more
core   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Major histocompatibility complex genomic investigation of endangered Chinese alligator provides insights into the evolution of tetrapod major histocompatibility complex and survival of critically bottlenecked species

Frontiers in Ecology and Evolution, 2022
BackgroundThe major histocompatibility complex (MHC) gene family, a vital immune gene family in vertebrates, helps animals defend against pathogens. The polymorphism of MHC genes is important for a species and is considered to be caused by the numerous ...
Ke He, Ke He, Ying Zhu, Ying Zhu, Shang-Chen Yang, Qing Ye, Qing Ye, Sheng-Guo Fang, Qiu-Hong Wan   +8 more
doaj   +1 more source

Increasing myosin light chain 3f (MLC3f) protects against a decline in contractile velocity [PDF]

, 2019
Disuse induces adaptations in skeletal muscle, which lead to muscle deterioration. Hindlimb-unloading (HU) is a well-established model to investigate cellular mechanisms responsible for disuse-induced skeletal muscle dysfunction.
Asakura, Atsushi, Graber, Ted G., Kim, Jong-Hee, Liu, Haiming, Thompson, LaDora V.   +4 more
core   +2 more sources

A 73‐Year‐Old Man With Several Years of Difficulty Climbing Stairs and Frequent Tripping

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 73‐year‐old man presented with progressive weakness and atrophy predominantly affecting the distal finger flexors and quadriceps muscles. Electrophysiological studies demonstrated mixed myogenic and neurogenic features. Muscle MRI showed inflammatory changes, and muscle biopsy revealed granulomatous myositis with histologic features ...
Mehmet Can Sari, Arens Taga, Sonya Ulrike Steele, Ahmet Hoke   +3 more
wiley   +1 more source

A Review of Suggested Mechanisms of MHC Odor Signaling

Biology, 2022
Although an individual’s mix of MHC immune genes determines its resistance, finding MHC-dependent mate choice occurred by accident in inbred mice. Inbred mice prefer MHC dissimilar mates, even when the choice was restricted to urine.
Manfred Milinski
doaj   +1 more source

Prediction of peptides binding to MHC class I alleles by partial periodic pattern mining [PDF]

, 2009
MHC (Major Histocompatibility Complex) is a key player in the immune response of an organism. It is important to be able to predict which antigenic peptides will bind to a specific MHC allele and which will not, creating possibilities for controlling ...
Meydan, Cem, Otu, Hasan, Sezerman, Uğur
core   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

The MHC locus and genetic susceptibility to autoimmune and infectious diseases

Genome Biology, 2017
In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also known as the human leukocyte antigen (HLA), have been reported as major risk factors for complex diseases.
V. Matzaraki, Vinod Kumar, C. Wijmenga, A. Zhernakova   +3 more
semanticscholar   +1 more source

Dosing strategies for switching from oral risperidone to paliperidone palmitate: Effects on clinical outcomes. [PDF]

, 2017
IntroductionThere are currently no guidelines for switching patients from oral risperidone to paliperidone palmitate (Invega Sustenna®). Furthermore, the paliperidone long-acting injectable (LAI) package insert does not recommend bridging with oral ...
Hsia, Stephanie L, Jackson, Elizabeth, Lacro, Jonathan P, Leckband, Susan G, Rao, Sanjai   +4 more
core   +2 more sources