Results 61 to 70 of about 349,873 (302)

A Review of Suggested Mechanisms of MHC Odor Signaling

Biology, 2022
Although an individual’s mix of MHC immune genes determines its resistance, finding MHC-dependent mate choice occurred by accident in inbred mice. Inbred mice prefer MHC dissimilar mates, even when the choice was restricted to urine.
Manfred Milinski
doaj   +1 more source

Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition.

Cancer Discovery, 2019
We performed a genomic, transcriptomic, and immunophenotypic study of 347 patients with diffuse large B-cell lymphoma (DLBCL) to uncover the molecular basis underlying acquired deficiency of MHC expression.
Daisuke Ennishi, K. Takata, W. Béguelin, Gerben Duns, A. Mottok, P. Farinha, Ali Bashashati, S. Saberi, M. Boyle, B. Meissner, S. Ben-Neriah, B. Woolcock, A. Telenius, D. Lai, Matt Teater, R. Kridel, K. Savage, L. Sehn, Ryan D. Morin, M. Marra, Sohrab P. Shah, J. Connors, R. Gascoyne, D. Scott, A. Melnick, C. Steidl   +25 more
semanticscholar   +1 more source

The critical role of CD4+ T cells in PD-1 blockade against MHC-II-expressing tumors such as classic Hodgkin lymphoma.

Blood Advances, 2020
Classic Hodgkin lymphoma (cHL) responds markedly to PD-1 blockade therapy, and the clinical responses are reportedly dependent on expression of major histocompatibility complex class II (MHC-II).
Joji Nagasaki, Y. Togashi, T. Sugawara, M. Itami, N. Yamauchi, J. Yuda, M. Sugano, Yuuki Ohara, Y. Minami, H. Nakamae, M. Hino, M. Takeuchi, H. Nishikawa   +12 more
semanticscholar   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway.

PLoS ONE, 2018
Major histocompatibility complex class II (MHC II) expression and turn-over are regulated via its ubiquitination by the membrane associated RING-CH 1 (MARCH1) E3 ligase. Unexpectedly, we show that MHC II ubiquitination also impacts MHC I.
Kayla R Wilson, Haiyin Liu, Geraldine Healey, Vivian Vuong, Satoshi Ishido, Marco J Herold, Jose A Villadangos, Justine D Mintern   +7 more
doaj   +1 more source

Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy

Nature Immunology, 2017
Exciting progress in the field of cancer immunotherapy has renewed the urgency of the need for basic studies of immunoregulation in both adaptive cell lineages and innate cell lineages.
Amira A. Barkal, K. Weiskopf, Kevin S. Kao, S. Gordon, B. Rosental, Y. Y. Yiu, B. George, Maxim Markovic, N. G. Ring, Jonathan M. Tsai, K. McKenna, P. Ho, Robin Z. Cheng, James Y Chen, Layla J. Barkal, A. Ring, I. Weissman, R. Maute   +17 more
semanticscholar   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The MHC locus and genetic susceptibility to autoimmune and infectious diseases

Genome Biology, 2017
In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also known as the human leukocyte antigen (HLA), have been reported as major risk factors for complex diseases.
V. Matzaraki, Vinod Kumar, C. Wijmenga, A. Zhernakova   +3 more
semanticscholar   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Emerging and Experimental Agents for Anal Cancer: What is New?

Journal of Experimental Pharmacology, 2021
João Paulo F Farias,1 Maria Helena C Rangel da Silva,2 Alexandre A Jácome2 1Department of Gastrointestinal Medical Oncology, Oncoclínicas, Rio de Janeiro, Brazil; 2Department of Gastrointestinal Medical Oncology, Oncoclínicas,
Farias JPF, Rangel da Silva MHC, Jácome AA   +2 more
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