Results 71 to 80 of about 505,271 (361)

Peptide exchange on MHC-I by TAPBPR is driven by a negative allostery release cycle. [PDF]

, 2018
Chaperones TAPBPR and tapasin associate with class I major histocompatibility complexes (MHC-I) to promote optimization (editing) of peptide cargo. Here, we use solution NMR to investigate the mechanism of peptide exchange.
A Bailey, A Blees, A Hateren van, A Hateren van, A Neerincx, A Neerincx, Andrew C. McShan, Avan Hateren, B Park, B Rodenko, C Hermann, C Hermann, C Thomas, C Thomas, CA Waudby, Clive R. Bagshaw, CM Ayres, CS Hee, David Flores-Solis, David H. Margulies, DM Korzhnev, E Kurimoto, EL Kovrigin, ET Abualrous, Evgenii L. Kovrigin, F Delaglio, F Sieker, GI Morozov, H Li, IR Kleckner, J Jiang, J Neefjes, JH Lee, Jiansheng Jiang, Jugmohit S. Toor, K Natarajan, Kannan Natarajan, KL Rock, LH Boyle, LO Pedersen, M Beerbaum, M Chen, M Wieczorek, Mareike Badstübner, MJ Barnden, MP Latham, NA Lakomek, Nikolaos G. Sgourakis, O Fisette, P Rossi, PA Wearsch, PA Wearsch, QR Chen, S Paul, S Yanaka, SO Ryan, V Montserrat, V Tugarinov, Vlad K. Kumirov, W Lee, W Pos, Y Shionoya, Z Hein   +62 more
core   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Redistribution of critical major histocompatibility complex and T cell receptor-binding functions of residues in an antigenic sequence after biterminal substitution [PDF]

, 1991
Residues critical for establishing a trimolecular interaction with a major histocompatibility complex (MHC)-encoded receptor and a T cell antigen receptor (TcR) were determined for an antigenic nonapeptide. The N-terminal residue proved to be involved in
Allen, Bhayani, Bjorkman, Chen, DeLisi, Fox, Garrett, Kourilsky, Lorenz, Lurquin, Maryanski, Reddehase, Reddehase, Reddehase, Rothbard, Schultz, Schwartz, Sette, Townsend   +18 more
core   +1 more source

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, EarlyView.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source

Emerging and Experimental Agents for Anal Cancer: What is New?

Journal of Experimental Pharmacology, 2021
João Paulo F Farias,1 Maria Helena C Rangel da Silva,2 Alexandre A Jácome2 1Department of Gastrointestinal Medical Oncology, Oncoclínicas, Rio de Janeiro, Brazil; 2Department of Gastrointestinal Medical Oncology, Oncoclínicas,
Farias JPF, Rangel da Silva MHC, Jácome AA   +2 more
doaj  

MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway.

PLoS ONE, 2018
Major histocompatibility complex class II (MHC II) expression and turn-over are regulated via its ubiquitination by the membrane associated RING-CH 1 (MARCH1) E3 ligase. Unexpectedly, we show that MHC II ubiquitination also impacts MHC I.
Kayla R Wilson, Haiyin Liu, Geraldine Healey, Vivian Vuong, Satoshi Ishido, Marco J Herold, Jose A Villadangos, Justine D Mintern   +7 more
doaj   +1 more source

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

FEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice. [PDF]

, 1994
Although mature CD4+ T cells bear T cell receptors (TCRs) that recognize class II major histocompatibility complex (MHC) and mature CD8+ T cells bear TCRs that recognize class I MHC, it is possible that the initial commitment of an immature thymocyte to ...
Fanslow, W, Fowlkes, B, Itano, A, ROBEY, Ellen   +3 more
core  

Digital gene expression analysis of the zebra finch genome [PDF]

, 2010
Background: In order to understand patterns of adaptation and molecular evolution it is important to quantify both variation in gene expression and nucleotide sequence divergence.
Balakrishnan, C.N., Burke, T., Ekblom, R., Slate , J.   +3 more
core   +4 more sources

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source