Results 81 to 90 of about 554,574 (392)
Emerging and Experimental Agents for Anal Cancer: What is New?
Journal of Experimental Pharmacology, 2021 João Paulo F Farias,1 Maria Helena C Rangel da Silva,2 Alexandre A Jácome2 1Department of Gastrointestinal Medical Oncology, Oncoclínicas, Rio de Janeiro, Brazil; 2Department of Gastrointestinal Medical Oncology, Oncoclínicas,
Farias JPF +2 more
doaj
The Journal of Immunology, 2011 I want to use this address to acknowledge my colleagues. The list is too long to mention, but each of them contributed to our work in important ways. I will mention my mentors: Thomas F. Roth at the University of California San Diego, Ray D.
openaire +2 more sources
Common Genetic Variant Association with Altered HLA Expression, Synergy with Pyrethroid Exposure, and Risk for Parkinson's Disease: An Observational and Case-Control Study. [PDF]
, 2015 Background/objectivesThe common non-coding single nucleotide polymorphism (SNP) rs3129882 in HLA-DRA is associated with risk for idiopathic Parkinson's disease (PD).
Boss, JM +11 more
core +2 more sources
Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation
Molecular Oncology, EarlyView.Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides +13 more
wiley +1 more source
Nature Communications, 2018 Potentiating anti-tumor immunity by inducing tumor inflammation and T cell-mediated responses are a promising area of cancer therapy. Immunomodulatory agents that promote these effects function via a wide variety of mechanisms, including upregulation of ...
N. Luo +12 more
semanticscholar +1 more source
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source
MHCflurry: open-source class I MHC binding affinity prediction
bioRxiv, 2017 Machine learning prediction of the interaction between major histocompatibility complex I (MHC I) proteins and their small peptide ligands is important for vaccine design and other applications in adaptive immunity.
Tim O’Donnell +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Nature Communications, 2022 MHC restriction depicts CD4+ T cell activation by MHC-II and CD8A+ by MHC-I, but rare T cells with mismatched MHC restriction have been reported. Here the authors use crystallography to describe features of such a mismatched TCR-MHC interaction and ...
Nishant K. Singh +13 more
doaj +1 more source
MHC and the viral hepatitides [PDF]
QJM, 2001 The outcome of a number of infectious diseases varies significantly between individuals. This is particularly evident for hepatitis B and hepatitis C virus infections, where the outcomes may range from asymptomatic self‐limiting infection to fulminant liver failure or to cirrhosis with hepatocellular carcinoma.
openaire +3 more sources