Evolution of major histocompatibility complex class I and class II genes in the brown bear [PDF]
BMC Evolutionary Biology, 2012 Background Major histocompatibility complex (MHC) proteins constitute an essential component of the vertebrate immune response, and are coded by the most polymorphic of the vertebrate genes.
Kuduk Katarzyna +7 more
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MHC-linked and un-linked class I genes in the wallaby [PDF]
BMC Genomics, 2009 Background MHC class I antigens are encoded by a rapidly evolving gene family comprising classical and non-classical genes that are found in all vertebrates and involved in diverse immune functions.
Harrow Jennifer +8 more
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Structure of a pheromone receptor-associated MHC molecule with an open and empty groove. [PDF]
PLoS Biology, 2005 Neurons in the murine vomeronasal organ (VNO) express a family of class Ib major histocompatibility complex (MHC) proteins (M10s) that interact with the V2R class of VNO receptors.
Rich Olson +3 more
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Different MHC class I cell surface expression levels in diverse chicken lines, associations with B blood group, and proposed relationship to antigen-binding repertoire [PDF]
Poultry ScienceThe Major Histocompatibility Complex (MHC) is a cluster of genes with primarily immune-related functions. The MHC class I genes are responsible for self- versus non-self-recognition and viral antigen presentation to T lymphocytes. The chicken MHC class I
Michael Kaiser +2 more
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MHC class I and II expression and induction in oligodendrocytes varies with age [PDF]
Scientific ReportsOligodendroglia expressing major histocompatibility complex (MHC) molecules have become of central interest in multiple sclerosis (MS) research, but their role in aging is still being elucidated.
Riley B. Catenacci +4 more
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Evidence of focusing the MHC class I immunopeptidome by tapasin. [PDF]
Front ImmunolDarley R +6 more
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Frontiers in Cell and Developmental Biology, 2023 Major histocompatibility complex (MHC) class I and II are crucial for the adaptive immune system because they are involved in peptide presentation to T cells.
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Present Yourself! By MHC Class I and MHC Class II Molecules [PDF]
Trends in Immunology, 2016 Since the discovery of MHC molecules, it has taken 40 years to arrive at a coherent picture of how MHC class I and MHC class II molecules really work. This is a story of the proteases and MHC-like chaperones that support the MHC class I and II molecules in presenting peptides to the immune system.
Rock, K.L., Reits, E., Neefjes, J.
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Natural killer cell tolerance persists despite significant reduction of self MHC class I on normal target cells in mice. [PDF]
PLoS ONE, 2010 A major group of murine inhibitory receptors on Natural Killer (NK) cells belong to the Ly49 receptor family and recognize MHC class I molecules. Infected or transformed target cells frequently downmodulate MHC class I molecules and can thus avoid CD8(+)
Petter Brodin +9 more
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MHC Class I Regulation: The Origin Perspective [PDF]
Cancers, 2020 Viral-derived elements and non-coding RNAs that build up “junk DNA” allow for flexible and context-dependent gene expression. They are extremely dense in the MHC region, accounting for flexible expression of the MHC I, II, and III genes and adjusting the level of immune response to the environmental stimuli.
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