Results 1 to 10 of about 275,601 (334)

Different MHC class I cell surface expression levels in diverse chicken lines, associations with B blood group, and proposed relationship to antigen-binding repertoire [PDF]

Poultry Science
The Major Histocompatibility Complex (MHC) is a cluster of genes with primarily immune-related functions. The MHC class I genes are responsible for self- versus non-self-recognition and viral antigen presentation to T lymphocytes. The chicken MHC class I
Michael Kaiser, Jim Kaufman, Susan J. Lamont   +2 more
doaj   +2 more sources

MHC class I and II expression and induction in oligodendrocytes varies with age [PDF]

Scientific Reports
Oligodendroglia expressing major histocompatibility complex (MHC) molecules have become of central interest in multiple sclerosis (MS) research, but their role in aging is still being elucidated.
Riley B. Catenacci, Danny Galleguillos, Adriana Rhodes, Sloan Phillips, Peter A. Calabresi   +4 more
doaj   +2 more sources

Targeted demethylation and activation of NLRC5 augment cancer immunogenicity through MHC class I. [PDF]

Proc Natl Acad Sci U S A
Sun X, Watanabe T, Oda Y, Shen W, Ahmad A, Ouda R, de Figueiredo P, Kitamura H, Tanaka S, Kobayashi KS.   +9 more
europepmc   +3 more sources

Evidence of focusing the MHC class I immunopeptidome by tapasin. [PDF]

Front Immunol
Darley R, Illing PT, Duriez P, Bailey A, Purcell AW, van Hateren A, Elliott T.   +6 more
europepmc   +3 more sources

Present Yourself! By MHC Class I and MHC Class II Molecules [PDF]

Trends in Immunology, 2016
Since the discovery of MHC molecules, it has taken 40 years to arrive at a coherent picture of how MHC class I and MHC class II molecules really work. This is a story of the proteases and MHC-like chaperones that support the MHC class I and II molecules in presenting peptides to the immune system.
Rock, K.L., Reits, E., Neefjes, J.
openaire   +4 more sources

Atlantic cod (Gadus morhua) MHC I localizes to endolysosomal compartments independently of cytosolic sorting signals

Frontiers in Cell and Developmental Biology, 2023
Major histocompatibility complex (MHC) class I and II are crucial for the adaptive immune system because they are involved in peptide presentation to T cells.
Synne Arstad Bjørnestad, Monica Hongrø Solbakken, Kjetill S. Jakobsen, Sissel Jentoft, Oddmund Bakke, Cinzia Progida   +5 more
doaj   +1 more source

MHC Class I Regulation: The Origin Perspective [PDF]

Cancers, 2020
Viral-derived elements and non-coding RNAs that build up “junk DNA” allow for flexible and context-dependent gene expression. They are extremely dense in the MHC region, accounting for flexible expression of the MHC I, II, and III genes and adjusting the level of immune response to the environmental stimuli.
Alicja Sznarkowska, Sara Mikac, Magdalena Pilch   +2 more
openaire   +2 more sources

Natural killer cell tolerance persists despite significant reduction of self MHC class I on normal target cells in mice. [PDF]

PLoS ONE, 2010
A major group of murine inhibitory receptors on Natural Killer (NK) cells belong to the Ly49 receptor family and recognize MHC class I molecules. Infected or transformed target cells frequently downmodulate MHC class I molecules and can thus avoid CD8(+)
Petter Brodin, Tadepally Lakshmikanth, Ramit Mehr, Maria H Johansson, Adil Doganay Duru, Adnane Achour, Mali Salmon-Divon, Klas Kärre, Petter Höglund, Sofia Johansson   +9 more
doaj   +1 more source

The MHC class I genes of zebrafish [PDF]

Developmental & Comparative Immunology, 2014
Major histocompatibility complex (MHC) molecules play a central role in the immune response and in the recognition of non-self. Found in all jawed vertebrate species, including zebrafish and other teleosts, MHC genes are considered the most polymorphic of all genes.
Hayley, Dirscherl, Sean C, McConnell, Jeffrey A, Yoder, Jill L O, de Jong   +3 more
openaire   +2 more sources

Allelic diversity and selection at the MHC class I and class II in a bottlenecked bird of prey, the White-tailed Eagle

BMC Evolutionary Biology, 2019
Background Genes of the Major Histocompatibility Complex (MHC) are essential for adaptive immune response in vertebrates, as they encode receptors that recognize peptides derived from the processing of intracellular (MHC class I) and extracellular (MHC ...
Piotr Minias, Ewa Pikus, Dariusz Anderwald   +2 more
doaj   +1 more source