Results 101 to 110 of about 279,104 (335)

The porcine Major Histocompatibility Complex and related paralogous regions: a review

Genetics Selection Evolution, 2000
The physical alignment of the entire region of the pig major histocompatibility complex (MHC) has been almost completed. In swine, the MHC is called the SLA (swine leukocyte antigen) and most of its class I region has been sequenced.
Vaiman Marcel, Gaillard Claire, Renard Christine, Chardon Patrick   +3 more
doaj   +1 more source

The MHC-encoded TAP1/LMP2 bidirectional promoter is down-regulated in highly oncogenic adenovirus type 12 transformed cells [PDF]

, 1933
Cells transformed by human adenovirus 12 (Ad12) exhibit extremely low surface levels of MHC class I molecules and contain reduced levels of class I heavy chain mRNAs.
Proffitt, James A, Blair, G.Eric
core   +1 more source

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

Identification of a CD4+ T cell-stimulating antigen of pathogenic bacteria by expression cloning. [PDF]

, 1995
Identifying the immunogenic proteins that elicit pathogen-specific T cell responses is key to rational vaccine design. While several approaches have succeeded in identifying major histocompatibility complex (MHC) class I bound peptides that stimulate CD8+
Campbell, D, Sanderson, S, SHASTRI, Nilabh   +2 more
core   +1 more source

High major histocompatibility complex class I polymorphism despite bottlenecks in wild and domesticated populations of the zebra finch () [PDF]

, 2015
Background Two subspecies of zebra finch, Taeniopygia guttata castanotis and T. g. guttata are native to Australia and the Lesser Sunda Islands, respectively.
A Aguilar, A Bowcock, A Hughes, A Sato, AA Borg, AN Rutstein, AR Whiteley, CH Kuo, Christopher N. Balakrishnan, CJ Rubin, CM Hess, CM Mesa, CN Balakrishnan, CN Balakrishnan, CN Balakrishnan, D Garrigan, Daniel J. Newhouse, DJ Wilson, E Mayr, ED Jarvis, F Cruz, F Pazderka, FK Barker, H Westerdahl, H Westerdahl, H-J Wallny, HC Miller, J Kaufman, J Neefjes, J Plachy, J Robinson, J Trowsdale, JA Anmarkrud, JA Eimes, JB Losos, JC Avise, JL Bollmer, JL Bollmer, JT Martinsohn, JT Sutton, KA Moutou, KD Matson, KM Miller, L Bernatchez, LG Spurgin, LG Spurgin, M Alcaide, M Alcaide, M Clement, M Koch, M Nei, M Nei, M Promerová, M Sorenson, M Stephens, M Stephens, MJ Ejsmond, MR Jones, P Librado, PW Hedrick, R Ekblom, R Frankham, R Frankham, R Wutzler, RAB Mason, RM Zink, RR Hudson, RR Hudson, S Griffith, S Sommer, SB Piertney, SC Galen, SV Edwards, SV Edwards, W Briles, W Forstmeier, WC Warren, Y Itoh   +77 more
core   +2 more sources

Microphysiological Systems of Lymphatics and Immune Organs

Advanced Healthcare Materials, EarlyView.
This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain, Ankur Singh, Andrés J. García   +2 more
wiley   +1 more source

MHC presentation via autophagy and how viruses escape from it [PDF]

, 2018
T cells detect infected and transformed cells via antigen presentation by major histocompatibility complex (MHC) molecules on the cell surface. For T cell stimulation, these MHC molecules present fragments of proteins that are expressed or taken up by ...
Gannage, Monique, Münz, Christian
core  

Class I major histocompatibility complexes loaded by a periodate trigger [PDF]

, 2009
Class I major histocompatibility complexes (MHCs) present peptide ligands on the cell surface for recognition by appropriate cytotoxic T cells. The unstable nature of unliganded MHC necessitates the production of recombinant class I complexes through in ...
Adams P. D., Back J. W., Bakker A. H., Bosques C. J., Bouvier M., Buist G. J., CCP4 (Collaborative Computational Project, No. 4), Chen D., Cobbold M., Emsley P., Evans P. R., Falkenburg J. H., Fremont D. H., Frickel E. M., Garboczi D. N., Gredmark-Russ S., Grotenbreg G. M., Grotenbreg G. M., Kamiya T., Leslie A. G. W., Ljunggren H. G., Madden D. R., Moroder L., Moss P., Murshudov G. N., Peggs K. S., Rammensee H., Rodenko B., Rooney C. M., Rosenberg S. A., Schumacher T. N., Schumacher T. N., Silver M. L., Soen Y., Stone J., Toebes M., Vriend G., Walter E. A., Yee C.   +38 more
core   +1 more source

Rat MHC class I peptides are immunogenic

Transplant International, 1996
We postulated that indirect recognition of MHC-derived peptides might modulate the alloresponse to donor antigen. In this study, we looked at the potential of two class I peptides derived from the alpha 1 and alpha 2 regions of the DA RT1Aa molecule. Lew responder rats were immunized by varying concentrations of two 25mer peptides covering residues 56 ...
N, Zavazava, F, Fandrich, K A, Ott, A, Freese, K, Turnewitsch   +4 more
openaire   +2 more sources

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source