TAPBPR alters MHC class I peptide presentation by functioning as a peptide exchange catalyst
eLife, 2015 Our understanding of the antigen presentation pathway has recently been enhanced with the identification that the tapasin-related protein TAPBPR is a second major histocompatibility complex (MHC) class I-specific chaperone. We sought to determine whether,
Clemens Hermann +9 more
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Segregation Analysis of Genotyped and Family-Phased, Long Range MHC Classical Class I and Class II Haplotypes in 5 Families With Type 1 Diabetes Proband in the United Arab Emirates [PDF]
, 2021 Guan K. Tay +6 more
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Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy
Advanced Functional Materials, EarlyView.FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao +8 more
wiley +1 more source
ROS‐Triggered Microgels for Programmable Drug Release in Volumetric Muscle Loss Repair
Advanced Healthcare Materials, EarlyView.Reduced graphene oxide‐incorporated hyaluronic acid microgels are developed as ROS‐responsive, injectable platforms for curcumin delivery in volumetric muscle loss. The microgels exhibit strong antioxidative activity, high drug‐loading capacity, and ROS‐triggered release.
Seungjun Lee +5 more
wiley +1 more source
Analysis of expression of MHC class I molecules and TAP genes in malignant human cell lines.
Folia Histochemica et Cytobiologica, 2007 TAP proteins (transporters associated with antigen processing) take part in the transport of oligopeptides created in proteasomes from cytoplasm into endoplasmic reticulum.
Elzbieta Kaczmarek +6 more
doaj +1 more source
Noncanonical peptides in complex with MHC class I
Expert Review of Vaccines, 2004 The major histocompatibility complex (MHC) presents canonical medium-high-affinity peptides on the surface of antigen-presenting cells to T-cells. Recognition of peptide MHC by T-cells initiates a cascade of signals which maintains a T-cell-dependent immune response.
Vasso, Apostolopoulos, Eliada, Lazoura
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The MHC-encoded TAP1/LMP2 bidirectional promoter is down-regulated in highly oncogenic adenovirus type 12 transformed cells [PDF]
, 1933 Cells transformed by human adenovirus 12 (Ad12) exhibit extremely low surface levels of MHC class I molecules and contain reduced levels of class I heavy chain mRNAs.
Proffitt, James A, Blair, G.Eric
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Advanced Healthcare Materials, EarlyView.A human cell‐based microphysiological system integrates engineered muscle tissues with an inflamed adipose–macrophage niche to model obese microenvironment‐induced muscle dysfunction. Muscle contraction is quantified by pillar deflection coupled with computational stiffness estimation. Secretome and transcriptomic profiling reveal inflammation‐mediated
Seunggyu Kim +16 more
wiley +1 more source
Class I major histocompatibility complexes loaded by a periodate trigger [PDF]
, 2009 Class I major histocompatibility complexes (MHCs) present peptide ligands on the cell surface for recognition by appropriate cytotoxic T cells. The unstable nature of unliganded MHC necessitates the production of recombinant class I complexes through in ...
Adams P. D. +38 more
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Advanced Healthcare Materials, EarlyView.Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro +4 more
wiley +1 more source