Results 141 to 150 of about 279,104 (335)

Major Histocompatibility Complex Class I Matching is Necessary but not Sufficient for Tolerance Induction to Vascularized Composite Allografts After Donor Hematopoietic Cell Transplantation

Transplantation Direct
Background. We previously reported a porcine model of vascularized composite allograft (VCA) transplantation with concurrent hematopoietic cell transplantation (HCT).
Elin Manell, DVM, PhD, M. Esad Gunes, MD, Sarah Merl, MBBS, Satyajit Patwardhan, MBBS, Ishit Chauhan, MBBS, Julie Hong, MD, Bryan Chen, BS, BA, Philip Jordache, BS, MS, Ahmed Almesalmy, BS, Dilrukshi Ekanayake-Alper, DVM, PhD, Dominik Hajosi, DVM, Sameera Husain, MD, Cheng-Shie Wuu, PhD, Matthew Wright, MD, Jarrod Bogue, MD, Christine Rohde, MD, Kumaran Shanmugarajah, MD, PhD, Curtis L Cetrulo, Jr, MD, David H. Sachs, MD, Joshua Weiner, MD   +19 more
doaj   +1 more source

Modulation of Natural Killer Cell Cytotoxicity in Human Cytomegalovirus Infection: The Role of Endogenous Class I Major Histocompatibility Complex and a Viral Class I Homolog [PDF]

, 1998
Natural killer (NK) cells have been implicated in early immune responses against certain viruses, including cytomegalovirus (CMV). CMV causes downregulation of class I major histocompatibility complex (MHC) expression in infected cells; however, it has ...
Bjorkman, Pamela J., Chapman, Tara L., Formankova, Danuska, Lanier, Lewis L., Leong, Clement C., Mocarski, Edward S., Phillips, Joseph H.   +6 more
core   +2 more sources

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source

Overexpression of MHC Class I in Muscle of Lymphocyte-Deficient Mice Causes a Severe Myopathy with Induction of the Unfolded Protein Response [PDF]

, 2013
Manuel Fréret, Laurent Drouot, Antoine Obry, Sandra Ahmed-Lacheheb, Claire Dauly, Sahil Adriouch, Pascal Cosette, François‐Jérôme Authier, Olivier Boyer   +8 more
openalex   +1 more source

MHC class I links with severe pathogenicity in C57BL/6N mice infected with SARS-CoV-2/BMA8 [PDF]

, 2023
Tian Qin, Beilei Shen, Entao Li, Song Jin, Rongbo Luo, Yiming Zhang, Jing Qi, Xiuwen Deng, Zhuangzhuang Shi, Tiecheng Wang, Yifa Zhou, Yuwei Gao   +11 more
openalex   +1 more source

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, EarlyView.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source

T cell recognition of nonpolymorphic determinants on H-2 class I molecules. [PDF]

, 1988
Recognition of polymorphic determinants on class I or class II MHC Ag is required for T lymphocyte responses. Using cell-size artificial membranes (pseudocytes) bearing H-2 class I Ag it is demonstrated that T cells can, in addition, recognize ...
Goldstein, SA, Mescher, MF
core  

Presentation of Cryptic Peptides by MHC Class I Is Enhanced by Inflammatory Stimuli [PDF]

, 2016
Sharanya Prasad, Shelley R. Starck, Nilabh Shastri   +2 more
openalex   +1 more source

DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss

Advanced Science, EarlyView.
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung‐Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D.C. Surboyo, Tomoki Maekawa, Triantafyllos Chavakis, George Hajishengallis   +11 more
wiley   +1 more source

Ubiquitination by March-I prevents MHC class II recycling and promotes MHC class II turnover in antigen-presenting cells [PDF]

, 2015
Kyungjin Cho, Even Walseng, Satoshi Ishido, Paul A. Roche   +3 more
openalex   +1 more source