Results 171 to 180 of about 275,601 (334)

Building trust in deep learning-based immune response predictors with interpretable explanations

Communications Biology
The ability to predict whether a peptide will get presented on Major Histocompatibility Complex (MHC) class I molecules has profound implications in designing vaccines.
Piyush Borole, Ajitha Rajan
doaj   +1 more source

Presentation of Exogenous Antigens on Major Histocompatibility Complex (MHC) Class I and MHC Class II Molecules Is Differentially Regulated during Dendritic Cell Maturation [PDF]

, 2003
Lélia Delamarre, Hilda Holcombe, Ira Mellman   +2 more
openalex   +1 more source

Single‐Cell RNA Sequencing of Thyroid Tissues Reveals Pathogenesis of Graves' Disease

Advanced Science, EarlyView.
Using single‐cell RNA sequencing and TCR profiling, this study constructed an immune cell atlas in thyroid tissue of Graves’ disease (GD), revealing dominant IFN‐γ‐secreting CD4+ T cells, expanded Tph and CD11c+ B cells, and enriched T/NK cells. Notably, GD thyroid follicular cells (TFCs) activated γδ T cells, which recruited cDC1 cells, suggesting a ...
Xiaoyi Zhou, Jia Cong, Rongguang Peng, Dichen Yang, Chenchen Dong, Jing Xie, Jiqi Yan, Jie Kuang, Fubin Li, Leng Siew Yeap, Xiaoyan Xie, Haolong Yin, Rulai Han, Liyun Shen, Yulin Zhou, Guang Ning, Shu Wang, Weiqing Wang, Lei Ye   +18 more
wiley   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Smohaze‐Upregulated RFWD3 Competes with TRIM24 to Stabilize TREX1 and Reduce Cytosolic dsDNA in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
The E3 ubiquitin ligase RFWD3 binds the exonuclease TREX1 and protects it from TRIM24‐mediated ubiquitination and degradation, leading to the eradication of intracellular dsDNA, inhibition of the cGAS‐STING pathway, and immunosuppressive microenvironment of lung cancer.
Xue‐Yan Shi, Yu‐Ke Shen, Meng‐Yao Lv, Yu Sun, Yong‐Fang Lin, Zheng Wang, Xiao‐Liang Jie, Zheng Liu, Yang‐Tong Liu, Yang‐Xin Fu, Zhenhua Ren, Gui‐Zhen Wang, Guang‐Biao Zhou   +12 more
wiley   +1 more source

IMMU-16. GUADECITABINE (SGI-110) ENHANCES MHC class I AND TUMOR ANTIGEN EXPRESSION ON MURINE C57BL/6-SYNGENEIC GLIOMA AND DIPG MODELS [PDF]

, 2018
Gary Kohanbash, Lauren McCarl, Karsen E. Shoger, Alberto Broniscer, Katherine E. Warren, Ian F. Pollack   +5 more
openalex   +1 more source

Supplementary figures from The Immunopeptidome from a Genomic Perspective: Establishing the Noncanonical Landscape of MHC Class I–Associated Peptides

, 2023
Georges Bedran, Hans-Christof Gasser, Kenneth Weke, Tongjie Wang, Dominika Bedran, Alexander Laird, Christophe Battail, Fabio Massimo Zanzotto, Cátia Pesquita, Håkan Axelson, Ajitha Rajan, David J. Harrison, Aleksander Pałkowski, Maciej Pawlik, Maciej Parys, J. Robert O’Neill, Paul M. Brennan, Stefan N. Symeonides, David R. Goodlett, Kevin Litchfield, Robin Fåhræus, Ted R. Hupp, Sachin Kote, Javier A. Alfaro   +23 more
openalex   +1 more source

4D Insights into Coral Biomineralization: Effects of Ocean Acidification on the Early Skeleton Development of a Stony Coral

Advanced Science, EarlyView.
Early coral skeletons grow through formation of two co‐joined zones, rapid accretion deposits and thickening deposits. Advanced imaging and simulations reveal that ocean acidification reshapes these zones, shifting the coral portfolio of mineral phases which alters skeletal resistance to mechanical stress.
Federica Scucchia, Katrein Sauer, Shah Fara, Tali Mass, Paul Zaslansky   +4 more
wiley   +1 more source

The Association of MHC Class I Proteins with the 2B4 Receptor Inhibits Self-Killing of Human NK Cells [PDF]

, 2010
Gili Betser-Cohen, Sa’ar Mizrahi, Moran Elboim, Osnat Alsheich-Bartok, Ofer Mandelboim   +4 more
openalex   +1 more source

MHC Class I Enables MSCs to Evade NK-Cell–Mediated Cytotoxicity and Exert Immunosuppressive Activity [PDF]

, 2022
Joo Youn Oh, Hyemee Kim, Hyun Ju Lee, Kangin Lee, Heather Barreda, Hyeon Ji Kim, Eunji Shin, Eun‐Hye Bae, Gagandeep Kaur, Yu Zhang, Eun Jae Kim, Jae young Lee, Ryang Hwa Lee   +12 more
openalex   +1 more source