Results 11 to 20 of about 279,104 (335)

Allelic diversity and selection at the MHC class I and class II in a bottlenecked bird of prey, the White-tailed Eagle

BMC Evolutionary Biology, 2019
Background Genes of the Major Histocompatibility Complex (MHC) are essential for adaptive immune response in vertebrates, as they encode receptors that recognize peptides derived from the processing of intracellular (MHC class I) and extracellular (MHC ...
Piotr Minias, Ewa Pikus, Dariusz Anderwald   +2 more
doaj   +1 more source

MHC Class I Expression by Donor Hematopoietic Stem Cells Is Required to Prevent NK Cell Attack in Allogeneic, but Not Syngeneic Recipient Mice. [PDF]

PLoS ONE, 2015
NK cells resist engraftment of syngeneic and allogeneic bone marrow (BM) cells lacking major histocompatibility (MHC) class I molecules, suggesting a critical role for donor MHC class I molecules in preventing NK cell attack against donor hematopoietic ...
Yuichi Hirata, Hao-Wei Li, Kazuko Takahashi, Hiroshi Ishii, Megan Sykes, Joji Fujisaki   +5 more
doaj   +1 more source

Evidence for directional selection at a novel major histocompatibility class I marker in wild common frogs (Rana temporaria) exposed to a viral pathogen (Ranavirus). [PDF]

, 2009
(c) 2009 Teacher et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
AA Cunningham, AA Cunningham, AL Hughes, Amber G. F. Teacher, AVS Hill, B Sammut, BC Clarke, BP Shum, D Posada, G Froeschke, GD Maniero, J Gantress, J Maynard Smith, J Robert, JM Seddon, JM Vyas, K Roelants, K Tamura, L Bernatchez, LF Jensen, M Nei, M Nonaka, M Ohtsuka, MA Beaumont, MF Flajnik, MF Flajnik, MF Flajnik, PC Doherty, PW Hedrick, R Frankham, RD Campbell, Richard A. Nichols, Robert DeSalle, S Berlin, S Conseguera, S Kumar, S Rozen, SB Piertney, T Antao, Trenton W. J. Garner, WE Briles, WF Bodmer, Y Ohta   +42 more
core   +6 more sources

Human cytomegalovirus UL18 utilizes US6 for evading the NK and T-cell responses. [PDF]

PLoS Pathogens, 2008
Human cytomegalovirus (HCMV) US6 glycoprotein inhibits TAP function, resulting in down-regulation of MHC class I molecules at the cell surface. Cells lacking MHC class I molecules are susceptible to NK cell lysis.
Youngkyun Kim, Boyoun Park, Sunglim Cho, Jinwook Shin, Kwangmin Cho, Youngsoo Jun, Kwangseog Ahn   +6 more
doaj   +1 more source

Tight Regulation of Major Histocompatibility Complex I for the Spatial and Temporal Expression in the Hippocampal Neurons

Frontiers in Cellular Neuroscience, 2021
The expression and function of immune molecules, such as major histocompatibility complex (MHC), within the developing and adult brain have been discovered over the past few years.
Yuqing Shen, Yuqing Shen, Jianqiong Zhang, Jianqiong Zhang, Jianqiong Zhang   +4 more
doaj   +1 more source

The E5 protein of BPV-4 interacts with the heavy chain of MHC class I and irreversibly retains the MHC complex in the Golgi apparatus [PDF]

, 2006
BPV-4 E5 inhibits transcription of the bovine MHC class I heavy chain (HC) gene, increases degradation of HC and downregulates surface expression of MHC class I by retaining the complex in the Golgi apparatus (GA).
Araibi, E.H., Ashrafi, G.H., Campo, M.S., Dornan, E.S., Ellis, S.A., Marchetti, B.   +5 more
core   +1 more source

Inborn errors of immunity affecting the MHC class I pathway for antigen presentationHuman MHC class I deficiency [PDF]

Journal of Human Immunity
The paper discusses rare inborn errors of immunity affecting MHC class I antigen processing, leading to infections and skin lesions, often misdiagnosed as autoimmune disease.
Stephan D. Gadola, Ömür Ardeniz, Angelica Cuapio, Jacques Zimmer, Hans-Gustaf Ljunggren   +4 more
doaj   +1 more source

The Major Histocompatibility Complex of Old World Camels—A Synopsis

Cells, 2019
This study brings new information on major histocompatibility complex (MHC) class III sub-region genes in Old World camels and integrates current knowledge of the MHC region into a comprehensive overview for Old World camels.
Martin Plasil, Sofia Wijkmark, Jean Pierre Elbers, Jan Oppelt, Pamela Anna Burger, Petr Horin   +5 more
doaj   +1 more source

Allelic diversity and patterns of selection at the major histocompatibility complex class I and II loci in a threatened shorebird, the Snowy Plover (Charadrius nivosus)

BMC Evolutionary Biology, 2020
Background Understanding the structure and variability of adaptive loci such as the major histocompatibility complex (MHC) genes is a primary research goal for evolutionary and conservation genetics.
Medardo Cruz-López, Guillermo Fernández, Helen Hipperson, Eduardo Palacios, John Cavitt, Daniel Galindo-Espinosa, Salvador Gómez del Angel, Raya Pruner, Oscar Gonzalez, Terry Burke, Clemens Küpper   +10 more
doaj   +1 more source

High levels of MeCP2 depress MHC class I expression in neuronal cells. [PDF]

PLoS ONE, 2007
BACKGROUND: The expression of MHC class I genes is repressed in mature neurons. The molecular basis of this regulation is poorly understood, but the genes are particularly rich in CpG islands. MeCP2 is a transcriptional repressor that binds to methylated
Julie Miralvès, Eddy Magdeleine, Lara Kaddoum, Hélène Brun, Sophie Peries, Etienne Joly   +5 more
doaj   +1 more source