Evolution of major histocompatibility complex class I and class II genes in the brown bear [PDF]
BMC Evolutionary Biology, 2012 Background Major histocompatibility complex (MHC) proteins constitute an essential component of the vertebrate immune response, and are coded by the most polymorphic of the vertebrate genes.
Kuduk Katarzyna +7 more
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Structure of a pheromone receptor-associated MHC molecule with an open and empty groove. [PDF]
PLoS Biology, 2005 Neurons in the murine vomeronasal organ (VNO) express a family of class Ib major histocompatibility complex (MHC) proteins (M10s) that interact with the V2R class of VNO receptors.
Rich Olson +3 more
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MHC-linked and un-linked class I genes in the wallaby [PDF]
BMC Genomics, 2009 Background MHC class I antigens are encoded by a rapidly evolving gene family comprising classical and non-classical genes that are found in all vertebrates and involved in diverse immune functions.
Harrow Jennifer +8 more
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MHC Class I Expression by Donor Hematopoietic Stem Cells Is Required to Prevent NK Cell Attack in Allogeneic, but Not Syngeneic Recipient Mice. [PDF]
PLoS ONE, 2015 NK cells resist engraftment of syngeneic and allogeneic bone marrow (BM) cells lacking major histocompatibility (MHC) class I molecules, suggesting a critical role for donor MHC class I molecules in preventing NK cell attack against donor hematopoietic ...
Yuichi Hirata +5 more
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Human cytomegalovirus UL18 utilizes US6 for evading the NK and T-cell responses. [PDF]
PLoS Pathogens, 2008 Human cytomegalovirus (HCMV) US6 glycoprotein inhibits TAP function, resulting in down-regulation of MHC class I molecules at the cell surface. Cells lacking MHC class I molecules are susceptible to NK cell lysis.
Youngkyun Kim +6 more
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BMC Evolutionary Biology, 2020 Background Understanding the structure and variability of adaptive loci such as the major histocompatibility complex (MHC) genes is a primary research goal for evolutionary and conservation genetics.
Medardo Cruz-López +10 more
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Induction of MHC Class I Expression by the MHC Class II Transactivator CIITA [PDF]
Immunity, 1997 Major histocompatibility complex (MHC) class I–deficient cell lines were used to demonstrate that the MHC class II transactivator (CIITA) can induce surface expression of MHC class I molecules. CIITA induces the promoter of MHC class I heavy chain genes. The site α DNA element is the target for CIITA-induced transactivation of class I.
Martin, Brian K +6 more
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The E5 protein of BPV-4 interacts with the heavy chain of MHC class I and irreversibly retains the MHC complex in the Golgi apparatus [PDF]
, 2006 BPV-4 E5 inhibits transcription of the bovine MHC class I heavy chain (HC) gene, increases degradation of HC and downregulates surface expression of MHC class I by retaining the complex in the Golgi apparatus (GA).
Araibi, E.H. +5 more
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Inborn errors of immunity affecting the MHC class I pathway for antigen presentationHuman MHC class I deficiency [PDF]
Journal of Human ImmunityThe paper discusses rare inborn errors of immunity affecting MHC class I antigen processing, leading to infections and skin lesions, often misdiagnosed as autoimmune disease.
Stephan D. Gadola +4 more
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High levels of MeCP2 depress MHC class I expression in neuronal cells. [PDF]
PLoS ONE, 2007 BACKGROUND: The expression of MHC class I genes is repressed in mature neurons. The molecular basis of this regulation is poorly understood, but the genes are particularly rich in CpG islands. MeCP2 is a transcriptional repressor that binds to methylated
Julie Miralvès +5 more
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