Results 191 to 200 of about 279,104 (335)

Surface emergence and persistence of MHC class I free heavy chains. [PDF]

J Biol Chem
Ruggiero FM, Mauvais FX, Wellbrock U, van Endert PM, Springer S.   +4 more
europepmc   +1 more source

An Obligatory Role for Lung Infiltrating B Cells in the Immunopathogenesis of Obliterative Airway Disease Induced by Antibodies to MHC Class I Molecules [PDF]

, 2012
Naohiko Fukami, Sabarinathan Ramachandran, Motoi Takenaka, Jonasz Jeremiasz Weber, Vijay Subramanian, T. Mohanakumar   +5 more
openalex   +1 more source

⁠Engineering Adaptive Immunity in 3D: A Patient‐Specific Lymphoid Model Using Stromal Networks and Peripheral Blood Mononuclear Cells

Advanced Science, EarlyView.
This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley   +1 more source

Chimeric MHC class I- and II-restricted non-self epitopes broaden antitumor T cell reactions. [PDF]

J Exp Med
Zhang R, Ma R, Leong MML, Watson IR, Iida K, Yaguchi T, Matsuda F, Honjo T, Chamoto K.   +8 more
europepmc   +1 more source

Supplemental Methods from Altered Binding of Tumor Antigenic Peptides to MHC Class I Affects CD8⁺ T Cell–Effector Responses

, 2023
Eleanor Clancy‐Thompson, Christine A. Devlin, Paul M. Tyler, Mariah M. Servos, Lestat R. Ali, Katherine S. Ventre, M. Aladdin Bhuiyan, Patrick T. Bruck, Michael E. Birnbaum, Stephanie K. Dougan   +9 more
openalex   +1 more source

Surface‐Associated Proteins on Extracellular Vesicles Remodel the Tumor Microenvironment by Potentiating TGF‐β Signaling in a Contact‐Dependent Manner

Advanced Science, EarlyView.
Extracellular vesicles (EVs) released from TGF‐β‐activated CAFs are enriched with ECM proteins such as TSG6 and THBS1, which facilitate their binding to recipient cell membranes. This EV–cell interaction promotes the clustering of CD44 and TGF‐β receptors on the target cell surface, thereby potentiating TGF‐β signaling activity. This study highlights a
Chao Li, Agustin Enciso‐Martinez, Lizhe Zhu, Sarah A. Rotman, Peter A. van Veelen, Roman I. Koning, Hailiang Mei, Peter ten Dijke   +7 more
wiley   +1 more source

METTL14 Regulates the Expression of Genes Related to Interferon, Interleukin and MHC Class I in Nasopharyngeal Carcinoma Cells. [PDF]

Cancer Med
Zhou Z, Wang J, Shen L, Han L, Li Q, Wu A, Li J, Liang Z, Zhu L, He D, Zhou Y, Huang S, Zhao Z, Cong J, Peng Z, Zhao P, Ye S, Bai B, Hong X, Dai G, Lei Y, Zhao W, Jia J, Lin X, Xiao D, Zhang Y, Lin T.   +26 more
europepmc   +1 more source

MHC class I and class II molecules are expressed in both human and mouse prostate tumor microenvironment

, 2006
Navreet K. Nanda, Lynn Birch, Norman M. Greenberg, Gail S. Prins   +3 more
openalex   +1 more source

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

Lipopeptide ligands captured by MHC class I molecules undergo dynamic conformational changes that affect their antigenic strength. [PDF]

J Biol Chem
Morita D, Fujii T, Inuki S, Suzuki H, Mikami B, Sugita M.   +5 more
europepmc   +1 more source