Results 221 to 230 of about 279,104 (335)

Comparison of MHC class I risk haplotypes in Thai and Caucasian psoriatics shows locus heterogeneity at PSORS1 [PDF]

, 2010
P. E. Stuart, Rajan P. Nair, Ravi Hiremagalore, P Kullavanijaya, P Kullavanijaya, Trilokraj Tejasvi, HENRY W. LIM, John J. Voorhees, James T. Elder   +8 more
openalex   +1 more source

CD20+FCRL4+ B Cells Activate CD8+ T Cells via MHC‐I Restriction in Nasopharyngeal Carcinoma Anti‐Tumor Immunity

Advanced Science, EarlyView.
CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang, Xiaotian Yuan, Kelei Gao, Bo You, Yaxuan Wang, Lai Meng, Zirong Chen, Shaobing Xie, Yunqing Liu, Zijian Dong, Shumin Xie, Ruohao Fan, Fengjun Wang, Junyi Zhang, Zhihai Xie, Yongzhen Mo, Hua Zhang, Weihong Jiang   +17 more
wiley   +1 more source

Clinical and immunological spectrum of MHC class I deficiency: insights from a long-term cohort with two novel mutations. [PDF]

Front Immunol
Haskologlu S, Ikinciogullari A, Islamoglu C, Bal SK, Bayrakoglu D, Erdem S, Karahan ZC, Ardeniz O, Aytekin C, Heper A, Ceylaner S, Dogu F.   +11 more
europepmc   +1 more source

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

Augmented MHC Class I on Professional Antigen-Presenting Cells and Enhanced Cytokine Production by CD8⁺ T Cells in Type 2 Diabetes Mellitus. [PDF]

Eur J Immunol
Liu S, Jayasinghe T, Kamińska D, Xu X, Ren X, Jiao Y, Kong Y, Li X, Li K, Antoniou AN, Li W, Błażewska K, Gendaszewska-Darmach E, Xu J, Garstka MA.   +14 more
europepmc   +1 more source

Reference‐Guided Chromosome‐by‐Chromosome de novo Assembly at Scale Using Low‐Coverage High‐Fidelity Long‐Reads with HiFiCCL

Advanced Science, EarlyView.
HiFiCCL, as the first assembly framework specifically designed for low‐coverage high‐fidelity reads, improves the assembly quality of existing assemblers and also enhances downstream applications such as large structural variant (SV) detection (>10 000 bp), synteny analysis, pangenome graph construction, and graph‐based individual‐specific germline SVs
Zhongjun Jiang, Weihua Pan, Runtian Gao, Heng Hu, Wentao Gao, Murong Zhou, Yu‐Hang Yin, Zhipeng Qian, Shuilin Jin, Guohua Wang   +9 more
wiley   +1 more source

Reversal of tumour immune evasion via enhanced MHC-Class-I antigen presentation by a dual-functional RNA regulated system. [PDF]

Mol Cancer
Meng C, Zhang H, Yi X, Kong G, Zhang X, Wang B, Xu Y, Qi H, Wu Q, Zhang K, Cao J, Lin X, Feng H, Chen J, Zheng S, Gu Z, Li H, Ling Q.   +17 more
europepmc   +1 more source

Expression of MHC class I, HLA-A and HLA-B identifies immune-activated breast tumors with favorable outcome [PDF]

, 2019
María del Mar Noblejas‐López, Cristina Nieto‐Jiménez, Sara Morcillo García, Javier Pérez‐Peña, Miriam Nuncia‐Cantarero, Fernando Andrés‐Pretel, Eva María Galán‐Moya, Eitan Amir, Atanasio Pandiella, Balázs Győrffy, Alberto Ocaña   +10 more
openalex   +1 more source

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source

Mutation of conserved MHC class I cytoplasmic tyrosine affects CD8+ T cell priming, effector function, and memory response. [PDF]

Front Immunol
Sun Y, Tang Y, Ortiz P, Nassif Rausseo B, Pazdrak B, Elzohary L, Katailiha A, Talukder A, Yee C, Davis RE, Lizée G.   +10 more
europepmc   +1 more source