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Figure S2. Downregulation of MHC class I on CD11b+Gr-1+ cells from anti-PD-1 resistant tumors. from Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy
, 2023 Xiaohong Wang, Jonathan E. Schoenhals, Ailin Li, David R. Valdecanas, Huiping Ye, Fenglin Zang, Chad Tang, Ming Tang, Chang-Gong Liu, Xiuping Liu, Sunil Krishnan, James P. Allison, Padmanee Sharma, Patrick Hwu, Ritsuko Komaki, Willem W. Overwijk, Daniel R. Gomez, Joe Y. Chang, Stephen M. Hahn, María Angélica Cortez, James W. Welsh +20 moreopenalex +1 more sourceCDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages
Advanced Science, EarlyView.CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng +17 morewiley +1 more sourceEZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma. [PDF]
iScienceEdmondson JL, Reed MR, Fil D, Heflin B, McKinnon A, Bauer MA, Morehead LC, Avaritt NL, Phillips M, Taverna SD, Tackett AJ, Koss B. +11 moreeuropepmc +1 more sourceFigure S9 from Hypoxia-Induced Long Noncoding RNA <i>HIF1A-</i><i>AS2</i> Regulates Stability of MHC Class I Protein in Head and Neck Cancer
Tsai‐Tsen Liao, Yu-Hsien Chen, Zih-Yu Li, An-Ching Hsiao, Ya-Li Huang, Ruo-Xin Hao, Shyh‐Kuan Tai, Pen‐Yuan Chu, Jing-Wen Shih, Hsing‐Jien Kung, Muh‐Hwa Yang +10 moreopenalex +1 more sourceSupplementary Table S2 from Treatment with Chemotherapy and Dendritic Cells Pulsed with Multiple Wilms' Tumor 1 (WT1)–Specific MHC Class I/II–Restricted Epitopes for Pancreatic Cancer
, 2023 Shigeo Koido, Sadamu Homma, Masato Okamoto, Kazuki Takakura, Masako Mori, Shinji Yoshizaki, Shintaro Tsukinaga, Shunichi Odahara, Seita Koyama, Hiroo Imazu, Kan Uchiyama, Mikio Kajihara, Hiroshi Arakawa, Takeyuki Misawa, Yoichi Toyama, Satoru Yanagisawa, Masahiro Ikegami, Shin Kan, Kazumi Hayashi, Hideo Komita, Yuko Kamata, Masaki Ito, Takefumi Ishidao, Sei-ichi Yusa, Shigetaka Shimodaira, Jianlin Gong, Haruo Sugiyama, Toshifumi Ohkusa, Hisao Tajiri +28 moreopenalex +1 more sourceA Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses
Advanced Science, EarlyView.Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li +9 morewiley +1 more sourceNanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan‐Coronavirus Vaccine Development
Advanced Science, EarlyView.Current SARS‐CoV‐2 vaccines generate short‐lived, strain‐specific immunity. A polymeric TLR7 agonist nanoparticle (TLR7‐NP) adjuvant enhances lymph node targeting and promotes early and sustained germinal center responses toward conserved S2 epitopes of the spike protein.Sijin Huang, Kanella M. Cohen, Liqiang Chen, Xiaowo Kang, Chang Liu, Megan E. Demouth, Wenxia Jiang, Alexander R. Maldeney, Rong Tong, Zunlong Ke, Kartik Chandran, Wei Luo, Qian Yin +12 morewiley +1 more source
