Results 241 to 250 of about 275,601 (334)

METTL5 Enables Immune Evasion of Liver Cancer via Chemokine mRNA Translation Regulation

Advanced Science, EarlyView.
METTL5 reshapes the tumor immune microenvironment through ribosome 18S rRNA m6A modification to regulate the translation of chemokine mRNA. Targeting METTL5‐mediated immunosuppression unleashes anti‐tumor immunity and improves the efficacy of anti‐PD‐1 therapy.
Shuang Li, Xiao Zhao, Tongtong Song, Qiaoyi Chen, Yanqing Wu, Yuting Zhang, Jingying Chen, Yifan Wu, Bin Li, Xinyue Zhang, Zihao Dai, Lixia Xu, Yubin Xie, Alfred Sze‐Lok Cheng, Jianping Guo, Ming Kuang, Shuibin Lin, Zhenwei Peng, Sui Peng, Xuezhen Zeng   +19 more
wiley   +1 more source

MHC class I trafficking signal improves induction of cytotoxic T lymphocyte using artificial antigen presenting cells. [PDF]

Biochem Biophys Rep
Sasaki K, Murata K, Minowa T, Shijubou N, Kobayashi H, Nakatsugawa M, Murai A, Mizue Y, Kubo T, Kanaseki T, Tsukahara T, Uhara H, Ishida-Yamamoto A, Hirohashi Y, Torigoe T.   +14 more
europepmc   +1 more source

A Biologically Informed Vision‐Guided Framework for Interpretable T Cell Receptor–Epitope Binding Prediction

Advanced Science, EarlyView.
Integrating hierarchical physicochemical features via a bio‐inspired design, the DAISY framework robustly predicts T‐cell receptor binding, significantly outperforming state‐of‐the‐art models on unseen epitopes. It uniquely offers visual interpretability via Score‐CAM visualizations and profound clinical relevance, correlating with T‐cell expansion ...
Yajing Yuan, Junwei Chen, Yufang Zhang, Yitian Fang, Zhongcheng Fang, Yanyi Chu, Jiayi Li, Chen Zhang, Yuzhe Li, Dongqing Wei   +9 more
wiley   +1 more source

Methodological approach for allele-specific antibody responses to HEK-293T-based cell lines expressing single MHC class I chain-related gene B antigens. [PDF]

BMC Mol Cell Biol
Jeon JH, Hong CH, Hyun YS, Lee H, Oh EJ, Kim TG, Baek IC.   +6 more
europepmc   +1 more source

ADAM metallopeptidase domain 17 (ADAM17) is naturally processed through major histocompatibility complex (MHC) class I molecules and is a potential immunotherapeutic target in breast, ovarian and prostate cancers

, 2010
Gomathinayagam Sinnathamby, Jennifer Zerfass, Julie Hafner, Peter D. Block, Zacharie Nickens, A. C. Hobeika, Angeles Alvarez Secord, H. Kim Lyerly, Michael A. Morse, Ramila Philip   +9 more
openalex   +2 more sources

MHC class I and II peptide homology regulates the cellular immune response

, 2020
Matthew M. Halpert, Vanaja Konduri, Dan Liang, Jonathan Vazquez‐Perez, Colby J. Hofferek, Scott A. Weldon, Yunyu Baig, Indira Vedula, Jonathan M. Levitt, William K. Decker   +9 more
openalex   +2 more sources

Glucocorticoid Receptor Activation Reprograms NK Cells to Drive AREG‐Mediated Immunosuppression: A Pan‐Cancer Role for AREG

Advanced Science, EarlyView.
Natural killer cells, central to anti‐tumor defense, undergo unexpected reprogramming within the tumor microenvironment. Instead of producing IFN‐γ and TNF‐α, they elevate amphiregulin, a tumor‐promoting factor. This shift is linked to glucocorticoid receptor activity and prostaglandin signaling.
Qin Wei, Guirong Liang, Rui zeng, Yuancheng Li, Anlan Hong, Hongsheng Wang, Suying Feng, Yan Wang, Yetao Wang   +8 more
wiley   +1 more source

Correction: Immunopeptidomics reveals determinants of <i>Mycobacterium tuberculosis</i> antigen presentation on MHC class I.

Elife
Leddy O, White FM, Bryson BD.
europepmc   +1 more source

Tuning ProteinMPNN to reduce protein visibility via MHC Class I through direct preference optimization. [PDF]

Protein Eng Des Sel
Gasser HC, Oyarzún DA, Alfaro JA, Rajan A.   +3 more
europepmc   +1 more source

Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury

Advanced Science, EarlyView.
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu, Bin Zhou, Chao Niu   +11 more
wiley   +1 more source