Results 271 to 280 of about 275,601 (334)

Corrigendum: Anti-cancer immune effect of human colorectal cancer neoantigen peptide based on MHC class I molecular affinity screening. [PDF]

Front Immunol
Zhang S, Huang C, Li Y, Li Z, Zhu Y, Yang L, Hu H, Sun Q, Liu M, Cao S.   +9 more
europepmc   +1 more source

Pre‐Existing Th1 Immunity Outperforms Age in Predicting Antibody Responses to SARS‐CoV‐2 Inactivated Vaccines

Advanced Science, EarlyView.
Challenging the focus on age, this study finds pre‐existing T helper 1 cells are the key biomarker for predicting antibody response to SARS‐CoV‐2 inactivated vaccines. In both mice and humans, high responders exhibited elevated baseline T helper 1 cells, which correlated with robust humoral immunity, offering crucial guidance for improving vaccine ...
Chanyuan Ye, Xiaoli Zhang, Lingfeng Qiu, Jia Ji, Jueqing Gu, Hongyu Jia, Yingfeng Lu, Jiyang Chen, Zelu Meng, Jiangshan Lian, Hangping Yao, Xun Zeng, Yida Yang   +12 more
wiley   +1 more source

Anti-cancer immune effect of human colorectal cancer neoantigen peptide based on MHC class I molecular affinity screening. [PDF]

Front Immunol
Zhang S, Huang C, Li Y, Li Z, Zhu Y, Yang L, Hu H, Sun Q, Liu M, Cao S.   +9 more
europepmc   +1 more source

Catalyst‐Free Collagen Filament Crosslinking for Engineering Anisotropic and Mechanically Robust Tissue Scaffolds

Advanced Science, EarlyView.
A bioorthogonal rhodamine/PEG crosslinking strategy is introduced to engineer dense collagen hydrogels with high mechanical resilience and cytocompatibility. Integration with wet‐spinning enables the fabrication of uniaxially aligned, cell‐laden collagen filaments that activate mechanotransductive signaling and support functional muscle regeneration in
JuYeon Kim, Hanjun Hwangbo, ByungJoon Choi, Dogeon Yoon, GeunHyung Kim   +4 more
wiley   +1 more source

SUS(d6)pending MHC class I peptide presentation for cancer immunoevasion. [PDF]

Cell Res
Dersh D, Yewdell JW.
europepmc   +1 more source

T Cell Exhaustion and Dendritic Cell‐Mediated Tertiary Lymphoid Structures (TLSs) Modulation Affect Response to Neoadjuvant Chemoradiotherapy in Microsatellite Stable Rectal Cancer

Advanced Science, EarlyView.
Using multi‐omics analysis, this study demonstrates that immune characteristics of the tumor microenvironment, rather than mutational profiles, are more strongly correlated with treatment response. Specifically, early exhausted T cells and tertiary lymphoid structures regulation by LAMP3⁺ dendritic cells emerge as key predictors of favorable outcomes ...
Miao Wang, Jiejun Shi, Kai Xu, Leyi Yu, Xiaomao Yin, Jiexuan Wang, Lin Zhu, Xin Yang, Jingjing Qian, Wenqiang Wang, Liangchen Zhu, Xuan Dai, Zekun Zhao, Jinran Wu, Dongsheng Li, Zhiqian Hu, Qi Huang, Xinxing Li   +17 more
wiley   +1 more source

The balance between nuclear import and export of NLRC5 regulates MHC class I transactivation. [PDF]

J Biol Chem
Zhu B, Ouda R, An N, Tanaka T, Kobayashi KS.   +4 more
europepmc   +1 more source

CD169+ Macrophage‐Targeted Immunomodulator to Restore Phagocytic Function and Enhance Antigen Presentation for Lymphatic Metastasis Eradication

Advanced Science, EarlyView.
A CD169+ macrophage‐targeted immunomodulator (G‐LNP@S‐D) is developed to co‐deliver a SHP2 inhibitor and STING agonist, thereby restoring phagocytic function, enhancing antigen presentation by CD169+ macrophages, and promoting T cell priming to eradicate lymphatic metastasis.
Xiayun Chen, Lichong Lu, Yibin Liu, Ziqi Liang, Jianqiao Li, Zhouchuan Shao, Youzhi Tang, Jianhua Zou, Shiying Li, Xiaoyuan Chen   +9 more
wiley   +1 more source

Spatial Transcriptomics and snRNA‐seq Expose CAF Niches Orchestrating Dual Stromal‐Immune Barriers in Hepatocellular Carcinoma

Advanced Science, EarlyView.
HmmyCAFs may form a triple immunosuppressive niche: possibly secrete ECM (POSTN, etc.) as physical barriers to block CD8⁺ T cells, induce CD8⁺ T exhaustion via those molecules, and use HIF‐1α‐driven metabolism to create acidic, nutrient‐poor microenvironments that suppress T cells.
Yingxue Li, Changxiang Huan, Haoting Sun, Wei Zhang, Zhen Guo, Chuanyu Li, Jia Yao, Zhiqi Zhang, Shizhe Yu, Qiongzhu Dong, Lunxiu Qin, Jinze Li, Lianqun Zhou   +12 more
wiley   +1 more source