Results 301 to 310 of about 279,104 (335)
Impaired endocytosis and accumulation in early endosomal compartments defines herpes simplex virus-mediated disruption of the nonclassical MHC class I-related molecule MR1. [PDF]
J Biol ChemSamer C +8 more
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Annual Review of Immunology, 1991
The introduction of cloned genes into the germline of mice has been proven to be a powerful tool to investigate the role of the respective gene products within the immune system. Here we summarize the transgenic mouse models that have been established with major histocompatibility complex (MHC) class-I genes.
B, Arnold, G J, Hämmerling
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The introduction of cloned genes into the germline of mice has been proven to be a powerful tool to investigate the role of the respective gene products within the immune system. Here we summarize the transgenic mouse models that have been established with major histocompatibility complex (MHC) class-I genes.
B, Arnold, G J, Hämmerling
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MHC class I and II deficiencies
Journal of Allergy and Clinical Immunology, 2014Deficiencies of MHC complex class I or II are rare primary immunodeficiencies, both of which are inherited in an autosomal recessive pattern. MHC class II deficiency is a prototype of a disease of gene regulation. Defects in transacting regulatory factors required for expression of MHC class II genes, rather than the genes themselves, are responsible ...
Suheir Hanna, Amos Etzioni
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Technologies for MHC class I immunoproteomics
Journal of Proteomics, 2010T cell epitopes are peptides, for instance derived from foreign, mutated or overexpressed proteins, that are displayed by MHC molecules on the cell surface and that are recognized by T lymphocytes. Knowledge of the identity of epitopes displayed by MHC molecules is of high value for diagnostic purposes and for the development of prophylactic and ...
Rieuwert, Hoppes +3 more
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Peptidases trimming MHC class I ligands
Current Opinion in Immunology, 2013Peptides presented by MHC class I molecules are typically produced through antigen degradation by the proteasome followed by trimming by exopeptidases. According to recent results, these include both aminopeptidases and carboxypeptidases in the cytosol and the endoplasmic reticulum. While cytosolic peptidases have a net neutral or destructive effect on
Mirjana, Weimershaus +3 more
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Establishing MHC Class I Peptide Motifs
2012Major histocompatibility complex (MHC) class I peptide motifs are used on a regular basis to identify and predict MHC class I ligands and CD8(+) T-cell epitopes. This approach is above all an invaluable tool for the identification of disease-associated epitopes.
Nico, Trautwein, Stefan, Stevanović
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1993
A great deal has already been learned from the analysis of beta 2m-mutant mice, but it is clear that a great deal remains to be learned. A significant (though unanticipated) problem with this model system is that it is functionally leaky: residual functional class I expression can be detected in beta 2m- mice, and small numbers of functional CD8 ...
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A great deal has already been learned from the analysis of beta 2m-mutant mice, but it is clear that a great deal remains to be learned. A significant (though unanticipated) problem with this model system is that it is functionally leaky: residual functional class I expression can be detected in beta 2m- mice, and small numbers of functional CD8 ...
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Peptide selection by MHC class I molecules
Nature, 1991Synthetic peptides have been used to sensitize target cells and thereby screen for epitopes recognized by T cells. Most epitopes of cytotoxic T lymphocytes can be mimicked by synthetic peptides of 12-15 amino acids. Although in specific cases, truncations of peptides improves sensitization of target cells, no optimum length for binding to major ...
T N, Schumacher +6 more
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Novel MHC class I-related molecule MR1 affects MHC class I expression in 293T cells
Biochemical and Biophysical Research Communications, 2008Association with beta(2)-microglobulin and binding a ligand are necessary conditions for cell surface expression of the antigen presenting molecules. MHC class I-related protein, MR1, is suggested to have an antigen presentation function, nevertheless the physiological ligand(s) is (are) still to be determined.
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