Results 301 to 310 of about 275,601 (334)

MHC class I and II deficiencies

Journal of Allergy and Clinical Immunology, 2014
Deficiencies of MHC complex class I or II are rare primary immunodeficiencies, both of which are inherited in an autosomal recessive pattern. MHC class II deficiency is a prototype of a disease of gene regulation. Defects in transacting regulatory factors required for expression of MHC class II genes, rather than the genes themselves, are responsible ...
Suheir Hanna, Amos Etzioni
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MHC Class-I Transgenic Mice

Annual Review of Immunology, 1991
The introduction of cloned genes into the germline of mice has been proven to be a powerful tool to investigate the role of the respective gene products within the immune system. Here we summarize the transgenic mouse models that have been established with major histocompatibility complex (MHC) class-I genes.
B, Arnold, G J, Hämmerling
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Technologies for MHC class I immunoproteomics

Journal of Proteomics, 2010
T cell epitopes are peptides, for instance derived from foreign, mutated or overexpressed proteins, that are displayed by MHC molecules on the cell surface and that are recognized by T lymphocytes. Knowledge of the identity of epitopes displayed by MHC molecules is of high value for diagnostic purposes and for the development of prophylactic and ...
Rieuwert, Hoppes, Reggy, Ekkebus, Ton N M, Schumacher, Huib, Ovaa   +3 more
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On the trail of empty MHC class-I

Molecular Immunology, 2013
Since being proposed nearly 25 years ago that MHC-I molecules free of peptide ligand possess a conformation that is distinct from that of the mature loaded form, considerable research has been conducted in order to isolate and characterise such a species.
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Distribution of mhc class i and of mhc class ii molecules in macrophages infected with Leishmania amazonensis

Journal of Cell Science, 1994
ABSTRACT Macrophages, being apparently the only cells that in vivo allow the growth of the intracellular pathogen Leishmania, are likely candidates to present antigens to Leishmania-specific CD4+ and CD8+ T lymphocytes, known to be involved in the resolution or in the development of lesions induced by these parasites, and recognizing ...
T, Lang, C, de Chastellier, C, Frehel, R, Hellio, P, Metezeau, S de S, Leao, J C, Antoine   +6 more
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Towards a systems understanding of MHC class I and MHC class II antigen presentation

Nature Reviews Immunology, 2011
The molecular details of antigen processing and presentation by MHC class I and class II molecules have been studied extensively for almost three decades. Although the basic principles of these processes were laid out approximately 10 years ago, the recent years have revealed many details and provided new insights into their control and specificity ...
Jacques, Neefjes, Marlieke L M, Jongsma, Petra, Paul, Oddmund, Bakke   +3 more
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Expression of MHC class I, MHC class II, and cancer germline antigens in neuroblastoma

Cancer Immunology, Immunotherapy, 2004
Neuroblastoma is the most common solid extracranial tumor in childhood, still with poor survival rates for metastatic disease. Neuroblastoma cells are of neuroectodermal origin and express a number of cancer germline (CG) antigens. These CG antigens may represent a potential target for immunotherapy such as peptide-based vaccination strategies.The ...
Matthias, Wölfl, Achim A, Jungbluth, Federico, Garrido, Teresa, Cabrera, Sharon, Meyen-Southard, Rüdiger, Spitz, Karen, Ernestus, Frank, Berthold   +7 more
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MHC Class I-Deficient Mice

1993
A great deal has already been learned from the analysis of beta 2m-mutant mice, but it is clear that a great deal remains to be learned. A significant (though unanticipated) problem with this model system is that it is functionally leaky: residual functional class I expression can be detected in beta 2m- mice, and small numbers of functional CD8 ...
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HFE, the MHC and hemochromatosis: Paradigm for an extended function for MHC class I

Tissue Antigens, 2003
Abstract: HFE was discovered as the hereditary hemochromatosis (HH) gene. It is located on chromosome 6 (6p21.3), 4Mb telomeric to the HLA‐A locus, and its product has a structure similar to MHC class I molecules. HFE encodes two frequent mutations: C282Y and H63D. One of these (C282Y) is present in a large proportion of Caucasian HH patients. HFE has
C S, Cardoso, M, de Sousa
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Evolution of MHC class I in the Order Crocodylia

Immunogenetics, 2013
The major histocompatibility complex (MHC) is a dynamic genomic region with an essential role in the adaptive immunity of jawed vertebrates. The evolution of the MHC has been dominated by gene duplication and gene loss, commonly known as the birth-and-death process. Evolutionary studies of the MHC have mostly focused on model species.
Jaratlerdsiri, Weerachai, Isberg, Sally R, Higgins, Damien P, Ho, Simon Y W, Salomonsen, Jan, Skjødt, Karsten, Miles, Lee G, Gongora, Jaime   +7 more
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