Results 311 to 320 of about 279,104 (335)
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Dysmyelination in class I MHC transgenic mice

Microscopy Research and Technique, 1995
AbstractWhy is it that oligodendrocytes do not normally express major histocompatibility complex (MHC) molecules? To examine the effect of aberrant MHC expression in oligodendrocytes, transgenic mice have been produced which expressed the class I MHC gene, H‐2Kb, under direction of the MBP promoter [Turnley et al.
A M, Turnley, G, Morahan
openaire   +2 more sources

Quality control of MHC class I maturation

The FASEB Journal, 2004
ABSTRACT Assembly of MHC class I molecules in the ER is regulated by the so‐called loading complex (LC). This multiprotein complex is of definite impor‐ tance for class I maturation, but its exact organization and order of assembly are not known.
Kajsa M, Paulsson, Ping, Wang
openaire   +2 more sources

Altered MHC class I antigens in tumors

International Journal of Clinical & Laboratory Research, 1997
MHC class I antigens are lost or downregulated in invasive tumors compared with autologous normal tissues. This is observed in most of the newly induced experimental tumors analyzed if they are cloned before passaging in vivo. Similarly, this is observed in 40%-90% of human tumors using the available panel of anti-HLA class I monoclonal antibodies.
I, Algarra, A, Collado, F, Garrido
openaire   +2 more sources

MHC Class I Gene Expression and Regulation

Journal of Hematotherapy & Stem Cell Research, 2000
Major histocompatibility complex (MHC) is a conglomerate of genes that play an important role in recognition of self and nonself. These genes are under tight control. In this review we have discussed the transcription processes regulating MHC gene expression. Various biological or chemical modulators can modulate MHC gene expression.
S, Agrawal, M C, Kishore
openaire   +2 more sources

MHC Class I Internalization via Autophagy Proteins

2019
Macroautophagy is a ubiquitous degradative pathway involved in innate and adaptive immunity. Its molecular machinery has been described to deliver intracellular and extracellular antigens to MHC class II loading compartment by regulating autophagosome and phagosome maturation.
Loi, Monica   +2 more
openaire   +2 more sources

Class I MHC presentation of exogenous antigens

Journal of Clinical Immunology, 1996
Class I MHC (MHC-I) molecules present primarily endogenous antigens, i.e. antigens that are present in the cytosol and are subject to the cytosolic processing mechanisms that comprise the conventional MHC-I processing pathway. However, exogenous antigens can also be present by MHC-I molecules in certain circumstances, particularly in the case of ...
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MHC class I and class II

Research in Immunology, 1993
B. Mach   +9 more
openaire   +1 more source

MHC Class I

1997
A. Neil Barclay   +5 more
openaire   +1 more source

MHC Class II Deficiency

2009
Mark Oette   +194 more
openaire   +1 more source

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