Results 311 to 320 of about 275,601 (334)

Peptide selection by MHC class I molecules

Nature, 1991
Synthetic peptides have been used to sensitize target cells and thereby screen for epitopes recognized by T cells. Most epitopes of cytotoxic T lymphocytes can be mimicked by synthetic peptides of 12-15 amino acids. Although in specific cases, truncations of peptides improves sensitization of target cells, no optimum length for binding to major ...
T N, Schumacher, M L, De Bruijn, L N, Vernie, W M, Kast, C J, Melief, J J, Neefjes, H L, Ploegh   +6 more
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Dysmyelination in class I MHC transgenic mice

Microscopy Research and Technique, 1995
AbstractWhy is it that oligodendrocytes do not normally express major histocompatibility complex (MHC) molecules? To examine the effect of aberrant MHC expression in oligodendrocytes, transgenic mice have been produced which expressed the class I MHC gene, H‐2Kb, under direction of the MBP promoter [Turnley et al.
A M, Turnley, G, Morahan
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Quality control of MHC class I maturation

The FASEB Journal, 2004
ABSTRACT Assembly of MHC class I molecules in the ER is regulated by the so‐called loading complex (LC). This multiprotein complex is of definite impor‐ tance for class I maturation, but its exact organization and order of assembly are not known.
Kajsa M, Paulsson, Ping, Wang
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Prediction of binding to MHC class I molecules

Journal of Immunological Methods, 1995
The binding of antigenic peptide sequences to major histocompatibility complex (MHC) molecules is a prerequisite for stimulation of cytotoxic T cell responses. Neural networks are here used to predict the binding capacity of polypeptides to MHC class I molecules encoded by the gene HLA-A*0201. Given a large database of 552 nonamers and 486 decamers and
H P, Adams, J A, Koziol
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MHC Class I Gene Expression and Regulation

Journal of Hematotherapy & Stem Cell Research, 2000
Major histocompatibility complex (MHC) is a conglomerate of genes that play an important role in recognition of self and nonself. These genes are under tight control. In this review we have discussed the transcription processes regulating MHC gene expression. Various biological or chemical modulators can modulate MHC gene expression.
S, Agrawal, M C, Kishore
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Altered MHC class I antigens in tumors

International Journal of Clinical & Laboratory Research, 1997
MHC class I antigens are lost or downregulated in invasive tumors compared with autologous normal tissues. This is observed in most of the newly induced experimental tumors analyzed if they are cloned before passaging in vivo. Similarly, this is observed in 40%-90% of human tumors using the available panel of anti-HLA class I monoclonal antibodies.
I, Algarra, A, Collado, F, Garrido
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Putting together an MHC class I molecule

Current Opinion in Immunology, 1993
Formation of MHC class I complexes involves proper folding of the subunits, their assembly and interaction with peptides. Several proteins contributing to this process have been described, but a number of questions remain, in particular those concerning early folding steps and interactions with peptide in the course of biosynthesis.
M J, Bijlmakers, H L, Ploegh
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The class I MHC gene family in mice

Immunology Today, 1986
Molecular genetic analysis of the murine MHC reveals that the class I gene family is far larger than expected from immunogenetic analysis of class I polypeptides. Of approximately 30 class I genes present in mouse DNA most are located telomeric to the H-2 regions in the adjacent Qa and Tla regions.
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Class I MHC presentation of exogenous antigens

Journal of Clinical Immunology, 1996
Class I MHC (MHC-I) molecules present primarily endogenous antigens, i.e. antigens that are present in the cytosol and are subject to the cytosolic processing mechanisms that comprise the conventional MHC-I processing pathway. However, exogenous antigens can also be present by MHC-I molecules in certain circumstances, particularly in the case of ...
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Establishing MHC Class I Peptide Motifs

2012
Major histocompatibility complex (MHC) class I peptide motifs are used on a regular basis to identify and predict MHC class I ligands and CD8(+) T-cell epitopes. This approach is above all an invaluable tool for the identification of disease-associated epitopes.
Nico, Trautwein, Stefan, Stevanović
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