Results 31 to 40 of about 275,601 (334)

The Epstein-Barr Virus G-Protein-Coupled Receptor Contributes to Immune Evasion by Targeting MHC Class I Molecules for Degradation [PDF]

, 2009
Epstein-Barr virus (EBV) is a human herpesvirus that persists as a largely subclinical infection in the vast majority of adults worldwide. Recent evidence indicates that an important component of the persistence strategy involves active interference with
AB Rickinson, AD Hislop, AD Hislop, AJ Hirsch, Andrew Currin, B Grinde, B Park, Bryan D. Griffin, CA Joazeiro, CD Gregory, CJ Barnstable, Claire Shannon-Lowe, DA Thorley-Lawson, DA Thorley-Lawson, DH Lee, DT Purtilo, EJ Wiertz, EJ Wiertz, Emmanuel J. H. J. Wiertz, EW Hewitt, F Wang, FC Zhou, GW Wilkinson, H Hengel, H Rabin, HG Guo, HJ Delecluse, HM Long, J Wess, J Yuan, J Zuo, Jianmin Zuo, JL Stern, JP Johnson, K Ahn, K Ahn, K Janvier, Klaus Früh, L Coscoy, L Coscoy, LA Lampson, LS Young, M Greenberg, M Rowe, M Rowe, Maaike E. Ressing, Martin Rowe, ME Ressing, MH Fogg, MH Furman, MJ Clague, MM Rosenkilde, MR Kasper, NB Lubben, NJ Stam, NL Glosson, O Schwartz, P Rivailler, PG Stevenson, PJ Lehner, PS Beisser, R Aasland, R Chaudhuri, R Zeidler, RS Milne, S Bauer, S Drose, S Ishido, S Keating, S Le Gall, S Montaner, SJ Paulsen, SP Lee, SP Lee, TH Meyer, TR Jones, TR Jones, TY Yang, U Reusch, VA Pudney, Wendy A. Thomas, Z Wang   +81 more
core   +4 more sources

Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8+ T Cell Responses

Cell Reports, 2016
The macroautophagy machinery has been implicated in MHC class II restricted antigen presentation. Here, we report that this machinery assists in the internalization of MHC class I molecules.
Monica Loi, Anne Müller, Karin Steinbach, Jennifer Niven, Rosa Barreira da Silva, Petra Paul, Laure-Anne Ligeon, Assunta Caruso, Randy A. Albrecht, Andrea C. Becker, Nicolas Annaheim, Heike Nowag, Jörn Dengjel, Adolfo García-Sastre, Doron Merkler, Christian Münz, Monique Gannagé   +16 more
doaj   +1 more source

Melanosomal targeting sequences from gp100 are essential for MHC class II-restricted endogenous epitope presentation and mobilization to endosomal compartments [PDF]

, 2006
CD4+ T lymphocytes play an important role in CD8+ T cell-mediated responses against tumors. Considering that about 20% of melanomas express major histocompatibility complex (MHC) class II, it is plausible that concomitant antigenic presentation by MHC ...
Lapointe, Réjean, Lepage, Stéphanie
core   +3 more sources

Immunoinformatic evaluation of the cross-presentation of donor major histocompatibility derived epitopes by recipient major histocompatibility class i molecules in transplantation rejection

Indian Journal of Transplantation, 2023
Aim: The aim of this study was to analyze the cross-presentation of allopeptides derived from donor major histocompatibility (MHC) molecules by recipient class I MHC molecules in the context of transplantation rejection.
Suhana Koothradan, K K Elyas
doaj   +1 more source

Recognition surfaces of MHC class I

Immunological Reviews, 1998
Summary: Recent crystallographic results have provided dose to atomic resolution views of the recognition events mediated by MHC class I molecules. The specificity‐conferring interaction of MHC class I/peptide with a T‐cell antigen receptor (TCR) appears dependent on certain key interactions with the MHC scaffold.
Jones, E, Tormo, J, Reid, S, Stuart, D
openaire   +2 more sources

Structural analysis of the adenovirus type 2 E3/19K protein using mutagenesis and a panel of conformation-sensitive monoclonal antibodies [PDF]

, 2008
The E3/19K protein of human adenovirus type 2 (Ad2) was the first viral protein shown to interfere with antigen presentation. This 25 kDa transmembrane glycoprotein binds to major histocompatibility complex (MHC) class I molecules in the endoplasmic ...
Ahmed, Altschul, Andersson, Beatrice Menz, Beier, Bennett, Bruder, Bryson, Burgert, Burgert, Burgert, Burgert, Burgert, Cole, Cox, Deryckere, Edgar, Elsing, Feuerbach, Flomenberg, Flomenberg, Fox, Gabathuler, Gewurz, Ginsberg, Hans-Gerhard Burgert, Hermiston, Hilgendorf, Jackson, Jackson, Jefferies, Katja Koebernick, Kornfeld, Krogh, Kurowski, Köhler, Körner, Lichtenstein, Liu, Liu, Lodoen, Mans, Martina Sester, McNees, McSharry, Nilsson, Persson, Pääbo, Pääbo, Pääbo, Ralf Schmid, Rawle, Rost, Rost, Rost, Sester, Sester, Tanaka, The_UniProt_Consortium, von Herrath, Windheim, Wold, Wold   +62 more
core   +1 more source

MHC and Evolution in Teleosts

Biology, 2016
Major histocompatibility complex (MHC) molecules are key players in initiating immune responses towards invading pathogens. Both MHC class I and class II genes are present in teleosts, and, using phylogenetic clustering, sequences from both classes have ...
Unni Grimholt
doaj   +1 more source

Antibody-mediated rejection of arterialised venous allografts is inhibited by immunosuppression in rats. [PDF]

PLoS ONE, 2014
OBJECTIVES AND DESIGN: We determined in a rat model (1) the presence and dynamics of alloantibodies recognizing MHC complexes on quiescent Brown-Norway (BN) splenic cells in the sera of Lewis (LEW) recipients of Brown-Norway iliolumbar vein grafts under ...
Katrin Splith, Peter Fellmer, Ivan Matia, Martin Varga, Martin Oliverius, Stephanie Kuhn, Linda Feldbrügge, Felix Krenzien, Hans-Michael Hau, Georg Wiltberger, Moritz Schmelzle, Sven Jonas   +11 more
doaj   +1 more source

Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules [PDF]

Proceedings of the National Academy of Sciences, 2001
The H-2Ldalloreactive 2C T cell receptor (TCR) is commonly considered as being positively selected on the H-2Kbmolecule. Surprisingly, 2C TCR+CD8+single-positive T cells emerge in massive numbers in fetal thymic organ culture originating from 2C transgenic, H-2KbDb−/−(2C+KbDb−/−) but not in fetal thymic organ culture from β2-microglobulin−/−2C ...
M M, Maurice, D S, Gould, J, Carroll, Y, Vugmeyster, H L, Ploegh   +4 more
openaire   +2 more sources

Lack of association between alopecia areata and HLA class I and II in a southeastern Brazilian population [PDF]

Anais Brasileiros de Dermatologia, 2016
: Background: Alopecia areata (AA) is a common disorder of unknown etiology that affects approximately 0.7% to 3.8% of patients among the general population. Currently, genetic and autoimmune factors are emphasized as etiopathogenic.
Ângela Marques Barbosa, Luiz Euribel Prestes-Carneiro, Aldri Roberta Sodoschi Sobral, Marcelo Jun Sakiyama, Bruna Cerávolo Lemos, Marilda Aparecida Milanez Morgado de Abreu, Luciana Leite Crivelin Martos, Ricardo Alberto Moliterno   +7 more
doaj   +1 more source