ATGs help MHC class II, but inhibit MHC class I antigen presentation [PDF]
Autophagy, 2016 We have recently shown that the LC3/Atg8 lipidation machinery of macroautophagy is involved in the internalization of MHC class I molecules. Decreased internalization in the absence of ATG5 or ATG7 leads to MHC class I surface stabilization on dendritic cells and macrophages, resulting in elevated CD8(+) T cell responses during viral infections and ...
Loi, Monica +2 more
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A pentapeptide as minimal antigenic determinant for MHC class I-restricted T lymphocytes [PDF]
, 1989 Peptides that are antigenic for T lymphocytes are ligands for two receptors, the class I or II glycoproteins that are encoded by genes in the major histocompatibility complex, and the idiotypic / chain T-cell antigen receptor1–9. That a peptide must bind
A Sette +30 more
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Rat interleukin-2-activated natural killer (A-NK) cell-mediated lysis is determined by the presence of CD18 on A-NK cells and the absence of major histocompatibility complex class I on target cells [PDF]
, 1994 The precise mechanism by which target cells are recognized and subsequently lysed by interleukin-2-activated natural killer (A-NK) cells is poorly understood. In this study the role of major histocompatibility complex (MHC) class I and adhesion molecules
Eggermont, A.M.M. (Alexander) +5 more
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Frontiers in Cellular and Infection Microbiology, 2020 Based on cell culture data, MHC class I downregulation by HCMV on infected cells has been suggested as a means of immune evasion by this virus. In order to address this issue in vivo, an immunohistochemical analysis of tissue sections from biopsy and ...
Florin Gabor +3 more
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Immuno, 2021 MHC class I molecules display intracellular peptides on cell surfaces to enable immune surveillance under pathological conditions. The source of MHC class I antigens responsible for cancer protection is not fully understood.
Serina Tokita +2 more
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Contrasting patterns of selection between MHC I and II across populations of Humboldt and Magellanic penguins [PDF]
, 2016 Indexación: Web of ScienceThe evolutionary and adaptive potential of populations or species facing an emerging infectious disease depends on their genetic diversity in genes, such as the major histocompatibility complex (MHC). In birds, MHC class I deals
Dantas, GPM +7 more
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Comparative genome analyses reveal distinct structure in the saltwater crocodile MHC.
PLoS ONE, 2014 The major histocompatibility complex (MHC) is a dynamic genome region with an essential role in the adaptive immunity of vertebrates, especially antigen presentation.
Weerachai Jaratlerdsiri +14 more
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Prediction of MHC class I binding peptides, using SVMHC
BMC Bioinformatics, 2002 Background T-cells are key players in regulating a specific immune response. Activation of cytotoxic T-cells requires recognition of specific peptides bound to Major Histocompatibility Complex (MHC) class I molecules.
Elofsson Arne, Dönnes Pierre
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Probing natural killer cell education by Ly49 receptor expression analysis and computational modelling in single MHC class I mice. [PDF]
PLoS ONE, 2009 Murine natural killer (NK) cells express inhibitory Ly49 receptors for MHC class I molecules, which allows for "missing self" recognition of cells that downregulate MHC class I expression.
Sofia Johansson +7 more
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MHC class I and class II structures
Current Opinion in Immunology, 1997 The basic structures of MHC class I and class II molecules are now well established. Over the past twelve months structural data on MHC class I molecules have provided details of the peptide binding groove for a number of alleles and have elaborated the mechanisms that allow binding of a range of peptides.
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