Results 41 to 50 of about 279,104 (335)
Comparative genome analyses reveal distinct structure in the saltwater crocodile MHC.
PLoS ONE, 2014 The major histocompatibility complex (MHC) is a dynamic genome region with an essential role in the adaptive immunity of vertebrates, especially antigen presentation.
Weerachai Jaratlerdsiri +14 more
doaj +1 more source
Recognition surfaces of MHC class I
Immunological Reviews, 1998 Summary: Recent crystallographic results have provided dose to atomic resolution views of the recognition events mediated by MHC class I molecules. The specificity‐conferring interaction of MHC class I/peptide with a T‐cell antigen receptor (TCR) appears dependent on certain key interactions with the MHC scaffold.
Jones, E, Tormo, J, Reid, S, Stuart, D
openaire +2 more sources
Statistical deconvolution of enthalpic energetic contributions to MHC-peptide binding affinity [PDF]
, 2006 Background: MHC Class I molecules present antigenic peptides to cytotoxic T cells, which forms an integral part of the adaptive immune response. Peptides are bound within a groove formed by the MHC heavy chain. Previous approaches to MHC Class I-peptide
Davies, M.N. +4 more
core +3 more sources
Induction of MHC Class I Expression by the MHC Class II Transactivator CIITA [PDF]
Immunity, 1997 Major histocompatibility complex (MHC) class I–deficient cell lines were used to demonstrate that the MHC class II transactivator (CIITA) can induce surface expression of MHC class I molecules. CIITA induces the promoter of MHC class I heavy chain genes. The site α DNA element is the target for CIITA-induced transactivation of class I.
Martin, Brian K +6 more
openaire +2 more sources
The Journal of Poultry Science, 2005 The aim of this study was to determine whether the expressions of MHC class I and II in the ovarian follicles change with follicular growth and aging of birds. Theca layer of white follicles (WF), the largest and the third largest preovulatory follicles
Kalpana Subedi, Yukinori Yoshimura
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2020 Based on cell culture data, MHC class I downregulation by HCMV on infected cells has been suggested as a means of immune evasion by this virus. In order to address this issue in vivo, an immunohistochemical analysis of tissue sections from biopsy and ...
Florin Gabor +3 more
doaj +1 more source
Probing natural killer cell education by Ly49 receptor expression analysis and computational modelling in single MHC class I mice. [PDF]
PLoS ONE, 2009 Murine natural killer (NK) cells express inhibitory Ly49 receptors for MHC class I molecules, which allows for "missing self" recognition of cells that downregulate MHC class I expression.
Sofia Johansson +7 more
doaj +1 more source
MHC Class I Antigen Processing Pathways
Human Immunology, 1997 The multistep process that culminates in major histocompatibility complex (MHC) class I presentation of foreign of self-peptides begins in the last phases of protein catabolism. Although the individual roles of many key molecules-such as proteasomes, the transporter associated with antigen processing, and various endoplasmic reticulum chaperones-have ...
A, Maffei, K, Papadopoulos, P E, Harris
openaire +2 more sources
Ecology and Evolution, 2020 The molecules encoded by major histocompatibility complex (MHC) genes play an essential role in the adaptive immune response among vertebrates. We investigated the molecular evolution of MHC class I genes in the sable Martes zibellina. We isolated 26 MHC
Baojun Zhao +8 more
doaj +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source