Results 51 to 60 of about 279,104 (335)

Prediction of MHC class I binding peptides, using SVMHC

BMC Bioinformatics, 2002
Background T-cells are key players in regulating a specific immune response. Activation of cytotoxic T-cells requires recognition of specific peptides bound to Major Histocompatibility Complex (MHC) class I molecules.
Elofsson Arne, Dönnes Pierre
doaj   +1 more source

Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles. [PDF]

, 1996
The killer cell inhibitory receptors (KIRs) are surface glycoproteins expressed by natural killer (NK) and T cells that specifically recognize defined groups of polymorphic human histocompatibility leukocyte antigen (HLA) class I molecules.
Chang, C, D'Andrea, A, Lanier, LL, Phillips, JH   +3 more
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Natural polymorphisms in Tap2 influence negative selection and CD4∶CD8 lineage commitment in the rat.

PLoS Genetics, 2014
Genetic variation in the major histocompatibility complex (MHC) affects CD4∶CD8 lineage commitment and MHC expression. However, the contribution of specific genes in this gene-dense region has not yet been resolved.
Jonatan Tuncel, Sabrina Haag, Anthony C Y Yau, Ulrika Norin, Amelie Baud, Erik Lönnblom, Klio Maratou, A Jimmy Ytterberg, Diana Ekman, Soley Thordardottir, Martina Johannesson, Alan Gillett, EURATRANS Consortium, Pernilla Stridh, Maja Jagodic, Tomas Olsson, Alberto Fernández-Teruel, Roman A Zubarev, Richard Mott, Timothy J Aitman, Jonathan Flint, Rikard Holmdahl   +21 more
doaj   +1 more source

Differential Targeting of Stem Cells and Differentiated Glioblastomas by NK Cells. [PDF]

, 2015
We have recently shown that Natural Killer (NK) cells control survival and differentiation of Cancer Stem-like Cells (CSCs) through two distinct phenotypes of cytotoxic and anergic NK cells, respectively. In this report, brain CSCs and their serum and NK
Bui, Vickie T, Cacalano, Nicholas, Inagaki, Akihito, Jewett, Anahid, Kasahara, Noriyuki, Man, Yan-Gao, Tseng, Han-Ching   +6 more
core   +1 more source

MHC class I and class II structures

Current Opinion in Immunology, 1997
The basic structures of MHC class I and class II molecules are now well established. Over the past twelve months structural data on MHC class I molecules have provided details of the peptide binding groove for a number of alleles and have elaborated the mechanisms that allow binding of a range of peptides.
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Xenografts of MHC-Deficient Mouse Embryonic Mesencephalon Improve Behavioral Recovery in Hemiparkinsonian Rats

Cell Transplantation, 2002
The limited availability of human embryonic tissue for dopamine cell transplants in Parkinson's patients has led to an increased interest in using xenogeneic donor tissue.
Lone M. Veng, Kimberly B. Bjugstad, Curt R. Freed, Philippa Marrack, Edward D. Clarkson, K. Patricia Bell, Cindy Hutt, W. Michael Zawada Ph.D.   +7 more
doaj   +1 more source

Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice. [PDF]

, 1994
Although mature CD4+ T cells bear T cell receptors (TCRs) that recognize class II major histocompatibility complex (MHC) and mature CD8+ T cells bear TCRs that recognize class I MHC, it is possible that the initial commitment of an immature thymocyte to ...
Fanslow, W, Fowlkes, B, Itano, A, ROBEY, Ellen   +3 more
core  

TAPBPR: a new player in the MHC class I presentation pathway. [PDF]

, 2015
In order to provide specificity for T cell responses against pathogens and tumours, major histocompatibility complex (MHC) class I molecules present high-affinity peptides at the cell surface to T cells.
Abe, Apcher, Apcher, Bakke, Basha, Bevan, Boyle, Boyle, Brewerton, Brocke, Burton, Chen, Chen, Cho, D'Alessio, Dalchau, Degen, Del Val, Denzin, Denzin, Deverson, Dick, Dong, Du Pasquier, Eisenlohr, Ellgaard, Elliott, Evans, Evnouchidou, Frickel, Gao, Garbi, Garstka, Garstka, Goulder, Grandea, Grandea, Greenwood, Hall, Ham, Hateren, Hermann, Howarth, Joffre, Kanaseki, Kienast, Kleijmeer, Korfali, Kozik, Kunte, Ladasky, Lampen, Landis, Leach, Lehner, Lewis, Lotteau, Marguet, Maric, Neisig, Oliveira, Ortmann, Paquet, Park, Park, Park, Paulsson, Peaper, Peaper, Peh, Petersen, Porter, Purcell, Reeves, Riberdy, Rizvi, Roche, Roche, Romagnoli, Rufer, Sadasivan, Salter, Saric, Saunders, Schlosstein, Serwold, Spies, Spies, Spies, Spiliotis, Starck, Sugita, Suh, Teng, Trowsdale, Turnquist, Turnquist, Vigna, Wearsch, Wearsch, Wei, Williams, Yewdell, York, Zernich, Zhang, Zhang   +106 more
core   +2 more sources