Results 61 to 70 of about 275,601 (334)

Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice. [PDF]

, 1994
Although mature CD4+ T cells bear T cell receptors (TCRs) that recognize class II major histocompatibility complex (MHC) and mature CD8+ T cells bear TCRs that recognize class I MHC, it is possible that the initial commitment of an immature thymocyte to ...
Fanslow, W, Fowlkes, B, Itano, A, ROBEY, Ellen   +3 more
core  

Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA [PDF]

, 1986
Transformation of murine thymocytes by radiation leukemia virus is associated with reduced expression of the class I antigens encoded in the major histocompatibility complex (MHC) and increased methylation and altered restriction enzyme patterns of MHC ...
Boral, Anthony, Buxbaum, Joel, Devlin, J., Flavell, Richard A., Kornreich, Ruth, Mellor, Andrew L., Meruelo, Daniel, Pampeno, Christine, Pellicer, Angel, Rossomando, Anthony, Silver, Jack L., Weiss, Elisabeth H.   +11 more
core   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

MHC class I loci of the Bar-Headed goose (Anser indicus)

Genetics and Molecular Biology, 2010
MHC class I proteins mediate functions in anti-pathogen defense. MHC diversity has already been investigated by many studies in model avian species, but here we chose the bar-headed goose, a worldwide migrant bird, as a non-model avian species. Sequences
Qinglong Liang, Lei Wei, Xinwei Wang, Hongxuan He   +3 more
doaj   +1 more source

Prediction of Major Histocompatibility Complex Binding with Bilateral and Variable Long Short Term Memory Networks

Biology, 2022
As an important part of immune surveillance, major histocompatibility complex (MHC) is a set of proteins that recognize foreign molecules. Computational prediction methods for MHC binding peptides have been developed.
Limin Jiang, Jijun Tang, Fei Guo, Yan Guo   +3 more
doaj   +1 more source

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. [PDF]

, 1996
Thymocytes must bind major histocompatibility complex (MHC) proteins on thymic epithelial cells in order to mature into either CD8+ cytotoxic T cells or CD4+ helper T cells.
Corbella, P, Itano, A, Kioussis, D, ROBEY, Ellen, Salmon, P, Tolaini, M   +5 more
core  

Induction of specific tolerance by intrathymic injection of recipient muscle cells transfected with donor class I major histocompatibility complex. [PDF]

, 1994
Induction of tolerance to allogeneic MHC antigens has been a goal in the field of transplantation because it would reduce or eliminate the need for generalized immunosuppression.
Geissler, Edward K., Jiao, Shoushu, Knechtle, Stuart J., Sumimoto, Ryo, Wang, Jue, Wolff, Jon   +5 more
core   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Xenografts of MHC-Deficient Mouse Embryonic Mesencephalon Improve Behavioral Recovery in Hemiparkinsonian Rats

Cell Transplantation, 2002
The limited availability of human embryonic tissue for dopamine cell transplants in Parkinson's patients has led to an increased interest in using xenogeneic donor tissue.
Lone M. Veng, Kimberly B. Bjugstad, Curt R. Freed, Philippa Marrack, Edward D. Clarkson, K. Patricia Bell, Cindy Hutt, W. Michael Zawada Ph.D.   +7 more
doaj   +1 more source

Tolerance of a Vascularized Composite Allograft Achieved in MHC Class-I-mismatch Swine via Mixed Chimerism

Frontiers in Immunology, 2022
BackgroundVascularized composite allografts (VCAs) allow reconstruction of devastating injuries and amputations, yet require lifelong immunosuppression that is associated with significant morbidity.
Alexandre G. Lellouch, Alexandre G. Lellouch, Alexandre G. Lellouch, Alexandre G. Lellouch, Alec R. Andrews, Alec R. Andrews, Alec R. Andrews, Gaelle Saviane, Gaelle Saviane, Gaelle Saviane, Zhi Yang Ng, Zhi Yang Ng, Ilse M. Schol, Ilse M. Schol, Marion Goutard, Marion Goutard, Marion Goutard, Marion Goutard, Amon-Ra Gama, Ivy A. Rosales, Robert B. Colvin, Laurent A. Lantieri, Mark A. Randolph, Mark A. Randolph, Mark A. Randolph, Gilles Benichou, Curtis L. Cetrulo, Curtis L. Cetrulo, Curtis L. Cetrulo, Curtis L. Cetrulo   +29 more
doaj   +1 more source